We evaluated the administration of raloxifene and veralipride in postmenopausal women with high osteoporosis risk and hot flushes in whom hormone replacement therapy (HRT) was contraindicated. A group of early postmenopausal women (n = 29) (mean age 51.8 Â± 4.1), complaining of severe vasomotor symptoms and with a bone mineral density (BMD) T-score between -1.5 and -2.5 were evaluated. They were randomly assigned to two treatment groups: raloxifene (60 mg/day) continuously in association with veralipride (100 mg/day) on alternate days (n = 17); or on alternate months (n = 12). BMD, serum prolactin concentration and endometrial thickness were assessed at baseline and after 6 months of therapy. Kupperman Index and hot flushes were assessed before and after 3 and 6 months of therapy. BMD was significantly higher at the end of therapy with an increase of 1.1%. Kupperman Index was significantly reduced after 3 months and a further decrease at 6 months was observed with both protocols. Both treatments led to a significant reduction of hot flushes after 3 and 6 months. No significant changes of prolactin levels were observed in either protocol. We found that the combined raloxifene-veralipride treatment, both every other day and every other month, led to a significant improvement in bone density and was effective in hot flushes and other menopause-associated symptoms. These protocols could represent a new way to administer raloxifene in early postmenopausal women at high osteoporosis risk with HRT contraindication.
|Data di pubblicazione:||2004|
|Titolo:||Veralipride administered in combination with raloxifene decreases hot flushes and improves bone density in early postmenopausal women|
|Autore/i:||Morgante, G.; Farina, Marco; Cianci, Antonio; La Marca, A.; Petraglia, F.; De Leo, V.|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1080/09513590410001692474|
|Codice identificativo ISI:||WOS:000221128400004|
|Codice identificativo Scopus:||2-s2.0-1942537139|
|Codice identificativo Pubmed:||15293890|
|Citazione:||Veralipride administered in combination with raloxifene decreases hot flushes and improves bone density in early postmenopausal women / Morgante, G.; Farina, Marco; Cianci, Antonio; La Marca, A.; Petraglia, F.; De Leo, V.. - In: GYNECOLOGICAL ENDOCRINOLOGY. - ISSN 0951-3590. - 18:4(2004), pp. 194-198.|
|Tipologia||Articolo su rivista|
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