Objective: To investigate the hypothalamo-pituitary-ovarian axis in women with functional hypothalamic amenorrhea to determine whether the combination of L-thyroxine and clomiphene citrate produces a qualitative and quantitative increase in induced ovulatory cycles. Setting: Gynecological Endocrinology Research Center, University of Siena (Italy). Patients: 16 young women with functional hypothalamic amenorrhea and 15 women with normal cycles in early follicular phase. Design: Administration of 50 Î¼g GnRH and 200 Î¼g TRH. The women with functional hypothalamic amenorrhea were divided into groups A (n=8) and B (n=8). Both groups were given 100 mg/day clomiphene for 5 days/month for 3 months. Women in group A were also given 75 mcg/day thyroid hormone (L-thyroxine) for 3 months. Main outcome measures: Comparison of basal and stimulated levels of gonadotropins, TSH and Prl, in groups A and B. Qualitative and quantitative comparison of ovulatory cycles induced in the groups. Results: Administration of clomiphene and clomiphene plus L-thyroxine was evaluated in the second and third months of treatment and was followed by a total of 11 ovulatory cycles, six in group A and five in group B. No significant difference was found between groups. Mean progesterone concentrations measured 16 days after the last clomiphene tablet were 5.5Â±1.2 ng/ml in group A and 5.1Â±1.3 ngl/ml in group B. Conclusions: Administration of L-thyroxine with clomiphene does not improve the response of the hypothalamo-pituitary-ovarian axis to clomiphene citrate or the number of ovulatory cycles and does not reduce luteal phase defects. Copyright (C) 2000 Elsevier Science Ireland Ltd.
|Data di pubblicazione:||2000|
|Titolo:||Administration of L-thyroxine does not improve the response of the hypothalamo-pituitary-ovarian axis to clomiphene citrate in functional hypothalamic amenorrhea|
|Autore/i:||De Leo, Vincenzo; La Marca, Antonio; Lanzetta, Danila; Morgante, Giuseppe|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0301-2115(99)00231-6|
|Codice identificativo ISI:||WOS:000086944500018|
|Codice identificativo Scopus:||2-s2.0-0034072707|
|Codice identificativo Pubmed:||10767520|
|Citazione:||Administration of L-thyroxine does not improve the response of the hypothalamo-pituitary-ovarian axis to clomiphene citrate in functional hypothalamic amenorrhea / De Leo, Vincenzo; La Marca, Antonio; Lanzetta, Danila; Morgante, Giuseppe. - In: EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY. - ISSN 0301-2115. - 90:1(2000), pp. 103-108.|
|Tipologia||Articolo su rivista|
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