The hypothalamo-pituitary-adrenal (HPA) axis is modulated by sex hormones. Few data exist on the relation between acute estrogen deficit and HPA axis response to corticotropin-releasing hormone (CRH). The effects of a sudden drop in estradiol levels on basal and CRH-stimulated levels of ACTH, cortisol, testosterone, androstenedione and 17-hydroxyprogesterone (17-OHP) were assessed in nine premenopausal women (44-48 years of age), before and after ovariectomy. The CRH test was performed before and 8 days after ovariectomy. A significant reduction in ACTH and adrenal steroids but not in cortisol response to CRH was observed after ovariectomy. The ratio of Δ(max) androstenedione/17-OHP after CRH stimulation was substantially the same before and after ovariectomy, whereas Δ(max) 17-OHP/cortisol was significantly lower in ovariectomized women showing increased 21- and 11β- hydroxylase activity. The results show that the acute estrogen deficit induces changes in the HPA axis characterized by reduced stimulated secretion of ACTH and steroids but normal stimulated cortisol production.

Hypothalamo-pituitary-adrenal axis and adrenal function before and after ovariectomy in premenopausal women / De Leo, Vincenzo; La Marca, Antonio; Talluri, Beatrice; D'Antona, Donato; Morgante, Giuseppe. - In: EUROPEAN JOURNAL OF ENDOCRINOLOGY. - ISSN 0804-4643. - 138:4(1998), pp. 430-435. [10.1530/eje.0.1380430]

Hypothalamo-pituitary-adrenal axis and adrenal function before and after ovariectomy in premenopausal women

La Marca, Antonio;
1998

Abstract

The hypothalamo-pituitary-adrenal (HPA) axis is modulated by sex hormones. Few data exist on the relation between acute estrogen deficit and HPA axis response to corticotropin-releasing hormone (CRH). The effects of a sudden drop in estradiol levels on basal and CRH-stimulated levels of ACTH, cortisol, testosterone, androstenedione and 17-hydroxyprogesterone (17-OHP) were assessed in nine premenopausal women (44-48 years of age), before and after ovariectomy. The CRH test was performed before and 8 days after ovariectomy. A significant reduction in ACTH and adrenal steroids but not in cortisol response to CRH was observed after ovariectomy. The ratio of Δ(max) androstenedione/17-OHP after CRH stimulation was substantially the same before and after ovariectomy, whereas Δ(max) 17-OHP/cortisol was significantly lower in ovariectomized women showing increased 21- and 11β- hydroxylase activity. The results show that the acute estrogen deficit induces changes in the HPA axis characterized by reduced stimulated secretion of ACTH and steroids but normal stimulated cortisol production.
1998
138
4
430
435
Hypothalamo-pituitary-adrenal axis and adrenal function before and after ovariectomy in premenopausal women / De Leo, Vincenzo; La Marca, Antonio; Talluri, Beatrice; D'Antona, Donato; Morgante, Giuseppe. - In: EUROPEAN JOURNAL OF ENDOCRINOLOGY. - ISSN 0804-4643. - 138:4(1998), pp. 430-435. [10.1530/eje.0.1380430]
De Leo, Vincenzo; La Marca, Antonio; Talluri, Beatrice; D'Antona, Donato; Morgante, Giuseppe
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1158442
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 32
  • ???jsp.display-item.citation.isi??? 33
social impact