Our data demonstrate an association between the germinal homozygous deletion of the CFHR1 gene and acute myeloid leukemia (AML) in the Caucasian population. The frequency of this deletion is 4 % in the healthy reference and the medulloblastoma populations, while it is 7 % in AML patients. The study may define a novel subtype of AML, with a peculiar etio-pathogenesis related to alterations of the complement factor cascade.
Association of CFHR1 homozygous deletion with acute myelogenous leukemia in the European population / Fratelli, Maddalena; Bolis, Marco; Kurosaki, Mami; Dori, Martina; Guarnaccia, Valeria; Spinelli, Orietta; Alberti, Marta; Valoti, Elisabetta; Pileggi, Silvana; Noris, Marina; Remuzzi, Giuseppe; Rambaldi, Alessandro; Terao, Mineko; Garattini, Enrico. - In: LEUKEMIA & LYMPHOMA. - ISSN 1042-8194. - 57:5(2016), pp. 1234-1237. [10.3109/10428194.2015.1082180]
Association of CFHR1 homozygous deletion with acute myelogenous leukemia in the European population
Dori, Martina;
2016
Abstract
Our data demonstrate an association between the germinal homozygous deletion of the CFHR1 gene and acute myeloid leukemia (AML) in the Caucasian population. The frequency of this deletion is 4 % in the healthy reference and the medulloblastoma populations, while it is 7 % in AML patients. The study may define a novel subtype of AML, with a peculiar etio-pathogenesis related to alterations of the complement factor cascade.
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