Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIVinfected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). Patients: HIV-infected patients with information on HBV surface antigen measurements and detectable HCV RNA, or a positive HCV antibody test result if HCV RNA measurements were not available. Measurements: Time-dependent Cox models to assess risk for NHL in treatment-naive patients and those initiating ART, with inverse probability weighting to control for informative censoring. Results: A total of 52 479 treatment-naive patients (1339 [2.6%] with chronic HBV infection and 7506 [14.3%] with HCV infection) were included, of whom 40 219 (77%) later started ART. The median follow-up was 13 months for treatment-naive patients and 50 months for those receiving ART. A total of 252 treatmentnaive patients and 310 treated patients developed NHL, with incidence rates of 219 and 168 cases per 100 000 person-years, respectively. The hazard ratios for NHL with HBV and HCV infection were 1.33 (95% CI, 0.69 to 2.56) and 0.67 (CI, 0.40 to 1.12), respectively, in treatment-naive patients and 1.74 (CI, 1.08 to 2.82) and 1.73 (CI, 1.21 to 2.46), respectively, in treated patients. Limitation: Many treatment-naive patients later initiated ART, which limited the study of the associations of chronic HBV and HCV infection with NHL in this patient group. Conclusion: In HIV-infected patients receiving ART, chronic coinfection with HBV and HCV is associated with an increased risk for NHL.

Chronic hepatitis B and C virus infection and risk for non-hodgkin lymphoma in HIV-infected patients: A cohort study / Wang, Qing; De Luca, Andrea; Smith, Colette; Zangerle, Robert; Sambatakou, Helen; Bonnet, Fabrice; Smit, Colette; Schommers, Philipp; Thornton, Alicia; Berenguer, Juan; Peters, Lars; Spagnuolo, Vincenzo; Ammassari, Adriana; Antinori, Andrea; Roldan, Eugenia Quiros; Mussini, Cristina; Miro, Jose M.; Konopnicki, Deborah; Fehr, Jan; Campbell, Maria A.; Termote, Monique; Bucher, Heiner C.; De Wit, Stéphane; Costagliola, Dominique; D'Arminio-Monforte, Antonella; Castagna, Antonella; Del Amo, Julia; Mocroft, Amanda; Raben, Dorthe; Chêne, Geneviève; Touloumi, Giota; Warszawski, Josiane; Meyer, Laurence; Dabis, François; Krause, Murielle Mary; Ghosn, Jade; Leport, Catherine; Wittkop, Linda; Reiss, Peter; Wit, Ferdinand; Prins, Maria; Sabin, Caroline; Gibb, Diana; Fätkenheuer, Gerd; Obel, Niels; Thorne, Claire; Kirk, Ole; Stephan, Christoph; Pérez-Hoyos, Santiago; Hamouda, Osamah; Bartmeyer, Barbara; Chkhartishvili, Nikoloz; Noguera-Julian, Antoni; D'Arminio Monforte, Antonella; Brockmeyer, Norbert; Prieto, Luis; Conejo, Pablo Rojo; Soriano-Arandes, Antoni; Battegay, Manuel; Rauch, Andri; Tookey, Pat; Casabona, Jordi; Goetghebuer, Tessa; Sönnerborg, Anders; Torti, Carlo; Teira, Ramon; Garrido, Myriam; Haerry, David; Bohlius, Julia; Bouteloup, Vincent; Cozzi-Lepri, Alessandro; Davies, Mary-Anne; Dorrucci, Maria; Dunn, David; Egger, Matthias; Furrer, Hansjakob; Guiguet, Marguerite; Grabar, Sophie; Judd, Ali; Lambotte, Olivier; Leroy, Valériane; Lodi, Sara; Matheron, Sophie; Monge, Susana; Nakagawa, Fumiyo; Paredes, Roger; Phillips, Andrew; Puoti, Massimo; Schomaker, Michael; Sterne, Jonathan; Thiebaut, Rodolphe; Van Der Valk, Marc; Wyss, Natasha; Barger, Diana; Schwimmer, Christine; Friis-Møller, Nina; Kjaer, Jesper; Brandt, Rikke Salbøl. - In: ANNALS OF INTERNAL MEDICINE. - ISSN 0003-4819. - 166:1(2017), pp. 9-17. [10.7326/M16-0240]

Chronic hepatitis B and C virus infection and risk for non-hodgkin lymphoma in HIV-infected patients: A cohort study

Mussini, Cristina;Lodi, Sara;
2017

Abstract

Background: Non-Hodgkin lymphoma (NHL) is the most common AIDS-defining condition in the era of antiretroviral therapy (ART). Whether chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection promote NHL in HIV-infected patients is unclear. Objective: To investigate whether chronic HBV and HCV infection are associated with increased incidence of NHL in HIVinfected patients. Design: Cohort study. Setting: 18 of 33 cohorts from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE). Patients: HIV-infected patients with information on HBV surface antigen measurements and detectable HCV RNA, or a positive HCV antibody test result if HCV RNA measurements were not available. Measurements: Time-dependent Cox models to assess risk for NHL in treatment-naive patients and those initiating ART, with inverse probability weighting to control for informative censoring. Results: A total of 52 479 treatment-naive patients (1339 [2.6%] with chronic HBV infection and 7506 [14.3%] with HCV infection) were included, of whom 40 219 (77%) later started ART. The median follow-up was 13 months for treatment-naive patients and 50 months for those receiving ART. A total of 252 treatmentnaive patients and 310 treated patients developed NHL, with incidence rates of 219 and 168 cases per 100 000 person-years, respectively. The hazard ratios for NHL with HBV and HCV infection were 1.33 (95% CI, 0.69 to 2.56) and 0.67 (CI, 0.40 to 1.12), respectively, in treatment-naive patients and 1.74 (CI, 1.08 to 2.82) and 1.73 (CI, 1.21 to 2.46), respectively, in treated patients. Limitation: Many treatment-naive patients later initiated ART, which limited the study of the associations of chronic HBV and HCV infection with NHL in this patient group. Conclusion: In HIV-infected patients receiving ART, chronic coinfection with HBV and HCV is associated with an increased risk for NHL.
2017
18-ott-2016
166
1
9
17
Chronic hepatitis B and C virus infection and risk for non-hodgkin lymphoma in HIV-infected patients: A cohort study / Wang, Qing; De Luca, Andrea; Smith, Colette; Zangerle, Robert; Sambatakou, Helen; Bonnet, Fabrice; Smit, Colette; Schommers, Philipp; Thornton, Alicia; Berenguer, Juan; Peters, Lars; Spagnuolo, Vincenzo; Ammassari, Adriana; Antinori, Andrea; Roldan, Eugenia Quiros; Mussini, Cristina; Miro, Jose M.; Konopnicki, Deborah; Fehr, Jan; Campbell, Maria A.; Termote, Monique; Bucher, Heiner C.; De Wit, Stéphane; Costagliola, Dominique; D'Arminio-Monforte, Antonella; Castagna, Antonella; Del Amo, Julia; Mocroft, Amanda; Raben, Dorthe; Chêne, Geneviève; Touloumi, Giota; Warszawski, Josiane; Meyer, Laurence; Dabis, François; Krause, Murielle Mary; Ghosn, Jade; Leport, Catherine; Wittkop, Linda; Reiss, Peter; Wit, Ferdinand; Prins, Maria; Sabin, Caroline; Gibb, Diana; Fätkenheuer, Gerd; Obel, Niels; Thorne, Claire; Kirk, Ole; Stephan, Christoph; Pérez-Hoyos, Santiago; Hamouda, Osamah; Bartmeyer, Barbara; Chkhartishvili, Nikoloz; Noguera-Julian, Antoni; D'Arminio Monforte, Antonella; Brockmeyer, Norbert; Prieto, Luis; Conejo, Pablo Rojo; Soriano-Arandes, Antoni; Battegay, Manuel; Rauch, Andri; Tookey, Pat; Casabona, Jordi; Goetghebuer, Tessa; Sönnerborg, Anders; Torti, Carlo; Teira, Ramon; Garrido, Myriam; Haerry, David; Bohlius, Julia; Bouteloup, Vincent; Cozzi-Lepri, Alessandro; Davies, Mary-Anne; Dorrucci, Maria; Dunn, David; Egger, Matthias; Furrer, Hansjakob; Guiguet, Marguerite; Grabar, Sophie; Judd, Ali; Lambotte, Olivier; Leroy, Valériane; Lodi, Sara; Matheron, Sophie; Monge, Susana; Nakagawa, Fumiyo; Paredes, Roger; Phillips, Andrew; Puoti, Massimo; Schomaker, Michael; Sterne, Jonathan; Thiebaut, Rodolphe; Van Der Valk, Marc; Wyss, Natasha; Barger, Diana; Schwimmer, Christine; Friis-Møller, Nina; Kjaer, Jesper; Brandt, Rikke Salbøl. - In: ANNALS OF INTERNAL MEDICINE. - ISSN 0003-4819. - 166:1(2017), pp. 9-17. [10.7326/M16-0240]
Wang, Qing; De Luca, Andrea; Smith, Colette; Zangerle, Robert; Sambatakou, Helen; Bonnet, Fabrice; Smit, Colette; Schommers, Philipp; Thornton, Alicia...espandi
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