Phenazone induces analgesia in the hot-plate test and decreases the number of cortical and pontine 5-HT binding sites A pre-treatment with PCPA prevents both the analgesic effect and the reduction of 5-HT binding sites caused by phenazone. These data suggest that the brain serotonin system may play a role in phenazone-induced antinociception.
BRAIN-SEROTONIN BINDING-CAPACITY, ANALGESIA AND DRUG SERUM LEVELS AFTER ACUTE TREATMENT WITH PHENAZONE IN RATS / Pini, Luigi Alberto; Vitale, Giovanni; Sandrini, Maurizio. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - STAMPA. - 25:(1992), pp. 258-259.
BRAIN-SEROTONIN BINDING-CAPACITY, ANALGESIA AND DRUG SERUM LEVELS AFTER ACUTE TREATMENT WITH PHENAZONE IN RATS
PINI, Luigi Alberto;VITALE, Giovanni;SANDRINI, Maurizio
1992
Abstract
Phenazone induces analgesia in the hot-plate test and decreases the number of cortical and pontine 5-HT binding sites A pre-treatment with PCPA prevents both the analgesic effect and the reduction of 5-HT binding sites caused by phenazone. These data suggest that the brain serotonin system may play a role in phenazone-induced antinociception.
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