Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

Vincent, Jean-Louis; Lefrant, Jean-Yves; Kotfis, Katarzyna; Nanchal, Rahul; Martin-Loeches, Ignacio; Wittebole, Xavier; Sakka, Samir G.; Pickkers, Peter; Moreno, Rui; Sakr, Yasser; Pavlik, P.; Manak, J.; Kieslichova, E.; Turek, R.; Fischer, M.; Valkova, R.; Dadak, L.; Dostal, P.; Malaska, J.; Hajek, R.; Židková, A.; Lavicka, P.; Medve, L.; Sarkany, A.; Kremer, I.; Marjanek, Z.; Tamasi, P.; Kolbusz, J.; Kübler, A.; Mielczarek, B.; Mikaszewska-Sokolewicz, M.; Kotfis, K.; Tamowicz, B.; Sulkowski, W.; Smuszkiewicz, P.; Pihowicz, A.; Trejnowska, E.; Hagau, N.; Filipescu, D.; Droc, G.; Lupu, M.; Nica, A.; Stoica, R.; Tomescu, D.; Constantinescu, D.; Valcoreanu Zbaganu, G.; Slavcovici, A.; Soskic, L.; Palibrk, I.; Jankovic, R.; Jovanovic, B.; Pandurovic, M.; Bumbasirevic, V.; Uljarevic, B.; Surbatovic, M.; Ladjevic, N.; Slobodianiuk, G.; Sobona, V.; Cikova, A.; Gebhardtova, A.; Cohen, J.; Sold, O.; Urbanek, P.; Schlieber, J.; Reisinger, J.; Auer, J.; Hartjes, A.; Lerche, A.; Janous, T.; Kink, E.; Krahulec, W.; Smolle, K.; Van Der Schueren, M.; Thibo, P.; Vanhoof, M.; Ahmet, I.; Philippe, G.; Dufaye, P.; Jacobs, O.; Fraipont, V.; Biston, P.; Dive, A.; Bouckaert, Y.; Gilbert, E.; Gressens, B.; Pinck, E.; Collin, V.; Vincent, J. L.; De Waele, J.; Rimachi, R.; Gusu, D.; De Decker, K.; Mandianga, K.; Heytens, L.; Wittebole, X.; Herbert, S.; Olivier, V.; Vandenheede, W.; Rogiers, P.; Kolodzeike, P.; Kruse, M.; Andersen, T.; Harjola, V.; Saarinen, K.; Leone, M.; Durocher, A.; Moulront, S.; Lepape, A.; Losser, M.; Cabaret, P.; Kalaitzis, E.; Zogheib, E.; Charve, P.; Francois, B.; Lefrant, J. Y.; Beilouny, B.; Forceville, X.; Misset, B.; Jacobs, F.; Bernard, F.; Payen, D.; Wynckel, A.; Castelain, V.; Faure, A.; Lavagne, P.; Thierry, L.; Moussa, M.; Vieillard-Baron, A.; Durand, M.; Gainnier, M.; Ichai, C.; Arens, S.; Hoffmann, C.; Kaffarnik, M.; Scharnofske, C.; Voigt, I.; Peckelsen, C.; Weber, M.; Gille, J.; Lange, A.; Schoser, G.; Sablotzki, A.; Jaschinski, U.; Bluethgen, A.; Vogel, F.; Tscheu, A.; Fuchs, T.; Wattenberg, M.; Helmes, T.; Scieszka, S.; Heintz, M.; Sakka, S.; Kohler, J.; Fiedler, F.; Danz, M.; Sakr, Y.; Riessen, R.; Kerz, T.; Kersten, A.; Tacke, F.; Marx, G.; Volkert, T.; Schmutz, A.; Nierhaus, A.; Kluge, S.; Abel, P.; Janosi, R.; Utzolino, S.; Bracht, H.; Toussaint, S.; Giannakou Peftoulidou, M.; Myrianthefs, P.; Armaganidis, A.; Routsi, C.; Xini, A.; Mouloudi, E.; Kokoris, I.; Kyriazopoulos, G.; Vlachos, S.; Lavrentieva, A.; Partala, P.; Nakos, G.; Barry, J.; O’Leary, R.; Motherway, C.; Faheem, M.; Dunne, E.; Donnelly, M.; Konrad, T.; Bonora, E.; Achilli, C.; Rossi, S.; Castiglione, G.; Peris, A.; Albanese, D.; Stocchetti, N.; Citerio, G.; Mozzoni, L.; Sisillo, E.; De Negri, P.; Savioli, M.; Vecchiarelli, P.; Puflea, F.; Stankovic, V.; Minoja, G.; Montibeller, S.; Calligaro, P.; Sorrentino, R.; Feri, M.; Zambon, M.; Colombaroli, E.; Giarratano, A.; Pellis, T.; Capra, C.; Antonelli, M.; Gullo, A.; Chelazzi, C.; De Capraris, A.; Patroniti, N.; Girardis, M.; Franchi, F.; Berlot, G.; Ponssen, H.; Ten Cate, J.; Bormans, L.; Husada, S.; Buise, M.; Van Der Hoven, B.; Reidinga, A.; Kuiper, M.; Pickkers, P.; Kluge, G.; Den Boer, S.; Kesecioglu, J.; Van Leeuwen, H.; Flaatten, H.; Mo, S.; Branco, V.; Rua, F.; Lafuente, E.; Sousa, M.; Catorze, N.; Barros, M.; Pereira, L.; Vintém De Oliveira, A.; Gomes, J.; Gaspar, I.; Pereira, M.; Cymbron, M.; Dias, A.; Almeida, E.; Beirao, S.; Serra, I.; Ribeiro, R.; Povoa, P.; Faria, F.; Costa-E-Silva, Z.; Nóbrega, J.; Fernandes, F.; Gabriel, J.; Voga, G.; Rupnik, E.; Kosec, L.; Kerin Povšic, M.; Osojnik, I.; Tomic, V.; Sinkovic, A.; González, J.; Zavala, E.; Pérez Valenzuela, J.; Marina, L.; Vidal-Cortés, P.; Posada, P.; Ignacio Martin-Loeches, A.; Muñoz Guillén, N.; Palomar, M.; Sole-Violan, J.; Torres, A.; Gonzalez Gallego, M.; Aguilar, G.; Montoiro Allué, R.; Argüeso, M.; Parejo, M.; Palomo Navarro, M.; Jose, A.; Nin, N.; Alvarez Lerma, F.; Martinez, O.; Tenza Lozano, E.; Arenal López, S.; Perez Granda, M.; Moreno, S.; Llubia, C.; De La Fuente Martos, C.; Gonzalez-Arenas, P.; Llamas Fernández, N.; Gil Rueda, B.; Estruch Pons, I.; Cruza, N.; Maroto, F.; Estella, A.; Ferrer, A.; Iglesias Fraile, L.; Quindos, B.; Quintano, A.; Tebar, M.; Cardinal, P.; Reyes, A.; Rodríguez, A.; Abella, A.; García Del Valle, S.; Yus, S.; Maseda, E.; Berezo, J.; Tejero Pedregosa, A.; Laplaza, C.; Ferrer, R.; Rico-Feijoo, J.; Rodríguez, M.; Monedero, P.; Eriksson, K.; Lind, D.; Chabanel, D.; Zender, H.; Heer, K.; Frankenberger, B.; Jakob, S.; Haller, A.; Mathew, S.; Downes, R.; Barrera Groba, C.; Johnston, A.; Meacher, R.; Keays, R.; Haji-Michael, P.; Tyler, C.; Ferguson, A.; Jones, S.; Tyl, D.; Ball, A.; Vogel, J.; Booth, M.; Downie, P.; Watters, M.; Brett, S.; Garfield, M.; Everett, L.; Heenen, S.; Dhir, S.; Beardow, Z.; Mostert, M.; Brosnan, S.; Pinto, N.; Harris, S.; Summors, A.; Andrew, N.; Rose, A.; Appelboam, R.; Davies, O.; Vickers, E.; Agarwal, B.; Szakmany, T.; Wimbush, S.; Welters, I.; Pearse, R.; Hollands, R.; Kirk-Bayley, J.; Fletcher, N.; Bray, B.; Brealey, D.; Delle Karth, G.; Draxler, V.; Filzwieser, G.; Heindl, W.; Kellner, G.; Lenz, K.; Rossmann, E.; Wiedermann, C.; Biston, P.; Chochrad, D.; Collin, V.; Damas, P.; Decruyenaere, J.; Hoste, E.; Devriendt, J.; Espeel, B.; Fraipont, V.; Installe, E.; Malbrain, M.; Nollet, G.; Preiser, J. C.; Raemaekers, J.; Roman, A.; Simon, M.; Spapen, H.; Swinnen, W.; Vallot, F.; Vincent, J. L.; Chytra, I.; Dadak, L.; Herold, I.; Polak, F.; Sterba, M.; Bestle, M.; Espersen, K.; Guldager, H.; Welling, K. -L.; Nyman, D.; Ruokonen, E.; Saarinen, K.; Annane, D.; Catogni, P.; Colas, G.; Coulomb, F.; Dorne, R.; Garrouste, M.; Isetta, C.; Larché, J.; Legall, J. -R.; Lessire, H.; Malledant, Y.; Mateu, P.; Ossart, M.; Payen, D.; Schlossmacher, P.; Timsit, J. -F.; Winnock, S.; Sollet, J. -P.; Mallet, L.; Maurer, P.; Sab, J. M.; Sollet, J. P.; Aykut, G.; Brunkhorst, F.; Nierhaus, A.; Lauterbach, M.; Ragaller, M.; Gatz, R.; Gerlach, H.; Henzler, D.; Hopf, H. -B.; Hueneburg, H.; Karzai, W.; Keller, A.; Bauer, T.; Kuhlmann, U.; Langgartner, J.; Manhold, C.; Ragaller, M.; Reith, B.; Schuerholz, T.; Spies, C.; Stögbauer, R.; Unterburger, J.; Clouva-Molyvdas, P. -M.; Giokas, G.; Ioannidou, E.; Lahana, A.; Liolios, A.; Marathias, K.; Nakos, G.; Tasiou, A.; Tsangaris, H.; Tamasi, P.; Marsh, B.; Power, M.; Sprung, C.; Biagioli, B.; Bobbio Pallavicini, F.; Pesenti, A.; Capra, C.; Della Corte, F.; Donadio, P. P.; Donati, A.; Giarratano, A.; Giorgio, T.; Giudici, D.; Greco, S.; Guadagnucci, A.; Lapichino, G.; Livigni, S.; Moise, G.; Nardi, G.; Panascia, E.; Pizzamiglio, M.; Ranieri, V. M.; Rosi, R.; Sicignano, A.; Solca, M.; Vignali, G.; Volpe Rinonapoli, I.; Barnas, M.; De Bel, E. E.; De Pont, A. -C.; Groeneveld, J.; Nijsten, M.; Sie, L.; Zandstra, D. F.; Harboe, S.; Lindén, S.; Lovstad, R. Z.; Moen, H.; Smith-Erichsen, N.; Piotrowski, A.; Karpel, E.; Almeida, E.; Moreno, R.; Pais-de-Lacerda, A.; Paiva, J. A.; Serra, I.; Pimentel, A.; Filipescu, D.; Jovanovic, K.; Malik, P.; Lucka, K.; Voga, G.; Aldecoa Alvarez-Santullano, C.; Artigas, A.; Zavala, E.; Escorsell, A.; Nicolas, J.; Izura Cea, J. J.; Marina, L.; Montejo, J.; Palencia, E.; Santos, F.; Sierra-Camerino, R.; Sipmann, F.; Zavala, E.; Brodersen, K.; Haggqvist, J.; Hermansson, D.; Hjelmqvist, H.; Heer, K.; Loderer, G.; Maggiorini, M.; Zender, H.; Andrews, P.; Appadu, B.; Barrera Groba, C.; Bewley, J.; Burchett, K.; Chambers, P.; Coakley, J.; Doberenz, D.; Eastwood, N.; Ferguson, A.; Fielden, J.; Gedney, J.; Gunning, K.; Harling, D.; Jankowski, S.; Jayson, D.; Kilner, A.; Krishna-Kumar, V.; Lei, K.; Mackenzie, S.; Macnaughton, P.; Marx, G.; Mcculloch, C.; Morgan, P.; Rhodes, A.; Roberts, C.; Russell, M.; Tupper-Carey, D.; Wright, M.; Twohey, L.; Watts, J.; Webster, R.; Williams, D.

doi:10.1007/s00134-017-5043-2

Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those in the SOAP study. The ICON patients were older (62.5 Â± 17.0 vs. 60.6 Â± 17.4 years) and had higher severity scores than the SOAP patients. The proportion of patients with sepsis at any time during the intensive care unit stay was slightly higher in the ICON study (31.9 vs. 29.6%, p = 0.03). In multilevel analysis, the adjusted odds of ICU mortality were significantly lower for ICON patients than for SOAP patients, particularly in patients with sepsis [OR 0.45 (0.35â 0.59), p < 0.001]. Conclusions: Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis.

Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP) / Vincent, J., Lefrant, J., Kotfis, K., Nanchal, R., Martin-Loeches, I., Wittebole, X., Sakka, S.G., Pickkers, P., Moreno, R., Sakr, Y., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., et al.. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - 44:3(2018), pp. 337-344. [10.1007/s00134-017-5043-2]

Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP)

Vincent, Jean-Louis;Lefrant, Jean-Yves;Kotfis, Katarzyna;Nanchal, Rahul;Martin-Loeches, Ignacio;Wittebole, Xavier;Sakka, Samir G.;Pickkers, Peter;Moreno, Rui;Sakr, Yasser;Pavlik, P.;Manak, J.;Kieslichova, E.;Turek, R.;Fischer, M.;Valkova, R.;Dadak, L.;Dostal, P.;Malaska, J.;Hajek, R.;Židková, A.;Lavicka, P.;Medve, L.;Sarkany, A.;Kremer, I.;Marjanek, Z.;Tamasi, P.;Kolbusz, J.;Kübler, A.;Mielczarek, B.;Mikaszewska-Sokolewicz, M.;Kotfis, K.;Tamowicz, B.;Sulkowski, W.;Smuszkiewicz, P.;Pihowicz, A.;Trejnowska, E.;Hagau, N.;Filipescu, D.;Droc, G.;Lupu, M.;Nica, A.;Stoica, R.;Tomescu, D.;Constantinescu, D.;Valcoreanu Zbaganu, G.;Slavcovici, A.;Soskic, L.;Palibrk, I.;Jankovic, R.;Jovanovic, B.;Pandurovic, M.;Bumbasirevic, V.;Uljarevic, B.;Surbatovic, M.;Ladjevic, N.;Slobodianiuk, G.;Sobona, V.;Cikova, A.;Gebhardtova, A.;Cohen, J.;Sold, O.;Urbanek, P.;Schlieber, J.;Reisinger, J.;Auer, J.;Hartjes, A.;Lerche, A.;Janous, T.;Kink, E.;Krahulec, W.;Smolle, K.;van der Schueren, M.;Thibo, P.;Vanhoof, M.;Ahmet, I.;Philippe, G.;Dufaye, P.;Jacobs, O.;Fraipont, V.;Biston, P.;Dive, A.;Bouckaert, Y.;Gilbert, E.;Gressens, B.;Pinck, E.;Collin, V.;Vincent, J. L.;de Waele, J.;Rimachi, R.;Gusu, D.;de decker, K.;Mandianga, K.;Heytens, L.;Wittebole, X.;Herbert, S.;Olivier, V.;Vandenheede, W.;Rogiers, P.;Kolodzeike, P.;Kruse, M.;Andersen, T.;Harjola, V.;Saarinen, K.;Leone, M.;Durocher, A.;Moulront, S.;Lepape, A.;Losser, M.;Cabaret, P.;Kalaitzis, E.;Zogheib, E.;Charve, P.;Francois, B.;Lefrant, J. Y.;Beilouny, B.;Forceville, X.;Misset, B.;Jacobs, F.;Bernard, F.;Payen, D.;Wynckel, A.;Castelain, V.;Faure, A.;Lavagne, P.;Thierry, L.;Moussa, M.;Vieillard-Baron, A.;Durand, M.;Gainnier, M.;Ichai, C.;Arens, S.;Hoffmann, C.;Kaffarnik, M.;Scharnofske, C.;Voigt, I.;Peckelsen, C.;Weber, M.;Gille, J.;Lange, A.;Schoser, G.;Sablotzki, A.;Jaschinski, U.;Bluethgen, A.;Vogel, F.;Tscheu, A.;Fuchs, T.;Wattenberg, M.;Helmes, T.;Scieszka, S.;Heintz, M.;Sakka, S.;Kohler, J.;Fiedler, F.;Danz, M.;Sakr, Y.;Riessen, R.;Kerz, T.;Kersten, A.;Tacke, F.;Marx, G.;Volkert, T.;Schmutz, A.;Nierhaus, A.;Kluge, S.;Abel, P.;Janosi, R.;Utzolino, S.;Bracht, H.;Toussaint, S.;Giannakou Peftoulidou, M.;Myrianthefs, P.;Armaganidis, A.;Routsi, C.;Xini, A.;Mouloudi, E.;Kokoris, I.;Kyriazopoulos, G.;Vlachos, S.;Lavrentieva, A.;Partala, P.;Nakos, G.;Barry, J.;O’Leary, R.;Motherway, C.;Faheem, M.;Dunne, E.;Donnelly, M.;Konrad, T.;Bonora, E.;Achilli, C.;Rossi, S.;Castiglione, G.;Peris, A.;Albanese, D.;Stocchetti, N.;Citerio, G.;Mozzoni, L.;Sisillo, E.;de Negri, P.;Savioli, M.;Vecchiarelli, P.;Puflea, F.;Stankovic, V.;Minoja, G.;Montibeller, S.;Calligaro, P.;Sorrentino, R.;Feri, M.;Zambon, M.;Colombaroli, E.;Giarratano, A.;Pellis, T.;Capra, C.;Antonelli, M.;Gullo, A.;Chelazzi, C.;de Capraris, A.;Patroniti, N.;Girardis, M.;Franchi, F.;Berlot, G.;Ponssen, H.;Ten Cate, J.;Bormans, L.;Husada, S.;Buise, M.;van der Hoven, B.;Reidinga, A.;Kuiper, M.;Pickkers, P.;Kluge, G.;Den Boer, S.;Kesecioglu, J.;van Leeuwen, H.;Flaatten, H.;Mo, S.;Branco, V.;Rua, F.;Lafuente, E.;Sousa, M.;Catorze, N.;Barros, M.;Pereira, L.;Vintém de Oliveira, A.;Gomes, J.;Gaspar, I.;Pereira, M.;Cymbron, M.;Dias, A.;Almeida, E.;Beirao, S.;Serra, I.;Ribeiro, R.;Povoa, P.;Faria, F.;Costa-E-Silva, Z.;Nóbrega, J.;Fernandes, F.;Gabriel, J.;Voga, G.;Rupnik, E.;Kosec, L.;Kerin Povšic, M.;Osojnik, I.;Tomic, V.;Sinkovic, A.;González, J.;Zavala, E.;Pérez Valenzuela, J.;Marina, L.;Vidal-Cortés, P.;Posada, P.;Ignacio Martin-Loeches, A.;Muñoz Guillén, N.;Palomar, M.;Sole-Violan, J.;Torres, A.;Gonzalez Gallego, M.;Aguilar, G.;Montoiro Allué, R.;Argüeso, M.;Parejo, M.;Palomo Navarro, M.;Jose, A.;Nin, N.;Alvarez Lerma, F.;Martinez, O.;Tenza Lozano, E.;Arenal López, S.;Perez Granda, M.;Moreno, S.;Llubia, C.;de la Fuente Martos, C.;Gonzalez-Arenas, P.;Llamas Fernández, N.;Gil Rueda, B.;Estruch Pons, I.;Cruza, N.;Maroto, F.;Estella, A.;Ferrer, A.;Iglesias Fraile, L.;Quindos, B.;Quintano, A.;Tebar, M.;Cardinal, P.;Reyes, A.;Rodríguez, A.;Abella, A.;García Del Valle, S.;Yus, S.;Maseda, E.;Berezo, J.;Tejero Pedregosa, A.;Laplaza, C.;Ferrer, R.;Rico-Feijoo, J.;Rodríguez, M.;Monedero, P.;Eriksson, K.;Lind, D.;Chabanel, D.;Zender, H.;Heer, K.;Frankenberger, B.;Jakob, S.;Haller, A.;Mathew, S.;Downes, R.;Barrera Groba, C.;Johnston, A.;Meacher, R.;Keays, R.;Haji-Michael, P.;Tyler, C.;Ferguson, A.;Jones, S.;Tyl, D.;Ball, A.;Vogel, J.;Booth, M.;Downie, P.;Watters, M.;Brett, S.;Garfield, M.;Everett, L.;Heenen, S.;Dhir, S.;Beardow, Z.;Mostert, M.;Brosnan, S.;Pinto, N.;Harris, S.;Summors, A.;Andrew, N.;Rose, A.;Appelboam, R.;Davies, O.;Vickers, E.;Agarwal, B.;Szakmany, T.;Wimbush, S.;Welters, I.;Pearse, R.;Hollands, R.;Kirk-Bayley, J.;Fletcher, N.;Bray, B.;Brealey, D.;Delle Karth, G.;Draxler, V.;Filzwieser, G.;Heindl, W.;Kellner, G.;Lenz, K.;Rossmann, E.;Wiedermann, C.;Biston, P.;Chochrad, D.;Collin, V.;Damas, P.;Decruyenaere, J.;Hoste, E.;Devriendt, J.;Espeel, B.;Fraipont, V.;Installe, E.;Malbrain, M.;Nollet, G.;Preiser, J. C.;Raemaekers, J.;Roman, A.;Simon, M.;Spapen, H.;Swinnen, W.;Vallot, F.;Vincent, J. L.;Chytra, I.;Dadak, L.;Herold, I.;Polak, F.;Sterba, M.;Bestle, M.;Espersen, K.;Guldager, H.;Welling, K. -L.;Nyman, D.;Ruokonen, E.;Saarinen, K.;Annane, D.;Catogni, P.;Colas, G.;Coulomb, F.;Dorne, R.;Garrouste, M.;Isetta, C.;Larché, J.;LeGall, J. -R.;Lessire, H.;Malledant, Y.;Mateu, P.;Ossart, M.;Payen, D.;Schlossmacher, P.;Timsit, J. -F.;Winnock, S.;Sollet, J. -P.;Mallet, L.;Maurer, P.;Sab, J. M.;Sollet, J. P.;Aykut, G.;Brunkhorst, F.;Nierhaus, A.;Lauterbach, M.;Ragaller, M.;Gatz, R.;Gerlach, H.;Henzler, D.;Hopf, H. -B.;Hueneburg, H.;Karzai, W.;Keller, A.;Bauer, T.;Kuhlmann, U.;Langgartner, J.;Manhold, C.;Ragaller, M.;Reith, B.;Schuerholz, T.;Spies, C.;Stögbauer, R.;Unterburger, J.;Clouva-Molyvdas, P. -M.;Giokas, G.;Ioannidou, E.;Lahana, A.;Liolios, A.;Marathias, K.;Nakos, G.;Tasiou, A.;Tsangaris, H.;Tamasi, P.;Marsh, B.;Power, M.;Sprung, C.;Biagioli, B.;Bobbio Pallavicini, F.;Pesenti, A.;Capra, C.;della Corte, F.;Donadio, P. P.;Donati, A.;Giarratano, A.;Giorgio, T.;Giudici, D.;Greco, S.;Guadagnucci, A.;Lapichino, G.;Livigni, S.;Moise, G.;Nardi, G.;Panascia, E.;Pizzamiglio, M.;Ranieri, V. M.;Rosi, R.;Sicignano, A.;Solca, M.;Vignali, G.;Volpe Rinonapoli, I.;Barnas, M.;de Bel, E. E.;de Pont, A. -C.;Groeneveld, J.;Nijsten, M.;Sie, L.;Zandstra, D. F.;Harboe, S.;Lindén, S.;Lovstad, R. Z.;Moen, H.;Smith-Erichsen, N.;Piotrowski, A.;Karpel, E.;Almeida, E.;Moreno, R.;Pais-de-Lacerda, A.;Paiva, J. A.;Serra, I.;Pimentel, A.;Filipescu, D.;Jovanovic, K.;Malik, P.;Lucka, K.;Voga, G.;Aldecoa Alvarez-Santullano, C.;Artigas, A.;Zavala, E.;Escorsell, A.;Nicolas, J.;Izura Cea, J. J.;Marina, L.;Montejo, J.;Palencia, E.;Santos, F.;Sierra-Camerino, R.;Sipmann, F.;Zavala, E.;Brodersen, K.;Haggqvist, J.;Hermansson, D.;Hjelmqvist, H.;Heer, K.;Loderer, G.;Maggiorini, M.;Zender, H.;Andrews, P.;Appadu, B.;Barrera Groba, C.;Bewley, J.;Burchett, K.;Chambers, P.;Coakley, J.;Doberenz, D.;Eastwood, N.;Ferguson, A.;Fielden, J.;Gedney, J.;Gunning, K.;Harling, D.;Jankowski, S.;Jayson, D.;Kilner, A.;Krishna-Kumar, V.;Lei, K.;Mackenzie, S.;Macnaughton, P.;Marx, G.;McCulloch, C.;Morgan, P.;Rhodes, A.;Roberts, C.;Russell, M.;Tupper-Carey, D.;Wright, M.;Twohey, L.;Watts, J.;Webster, R.;Williams, D.

2018

Abstract

Purpose: To evaluate differences in the characteristics and outcomes of intensive care unit (ICU) patients over time. Methods: We reviewed all epidemiological data, including comorbidities, types and severity of organ failure, interventions, lengths of stay and outcome, for patients from the Sepsis Occurrence in Acutely ill Patients (SOAP) study, an observational study conducted in European intensive care units in 2002, and the Intensive Care Over Nations (ICON) audit, a survey of intensive care unit patients conducted in 2012. Results: We compared the 3147 patients from the SOAP study with the 4852 patients from the ICON audit admitted to intensive care units in the same countries as those in the SOAP study. The ICON patients were older (62.5 Â± 17.0 vs. 60.6 Â± 17.4 years) and had higher severity scores than the SOAP patients. The proportion of patients with sepsis at any time during the intensive care unit stay was slightly higher in the ICON study (31.9 vs. 29.6%, p = 0.03). In multilevel analysis, the adjusted odds of ICU mortality were significantly lower for ICON patients than for SOAP patients, particularly in patients with sepsis [OR 0.45 (0.35â 0.59), p < 0.001]. Conclusions: Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis.

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	Anno di pubblicazione
	
				2018
			
	Data di prima pubblicazione
	
				15-feb-2018
			
	Rivista
	
				INTENSIVE CARE MEDICINE
			
	N° del Volume
	
				44
			
	Fascicolo
	
				3
			
	Pagina iniziale
	
				337
			
	Pagina finale
	
				344
			
	Codice DOI
	
				https://dx.doi.org/10.1007/s00134-017-5043-2
			
	Codice WoS
	
				WOS:000427970900005
			
	Codice Scopus
	
				2-s2.0-85042129933
			
	Codice PubMed
	
				29450593
			
	Citazione
	
				Comparison of European ICU patients in 2012 (ICON) versus 2002 (SOAP) / Vincent, J., Lefrant, J., Kotfis, K., Nanchal, R., Martin-Loeches, I., Wittebole, X., Sakka, S.G., Pickkers, P., Moreno, R., Sakr, Y., Pavlik, P., Manak, J., Kieslichova, E., Turek, R., Fischer, M., Valkova, R., Dadak, L., Dostal, P., Malaska, J., Hajek, R., et al.. - In: INTENSIVE CARE MEDICINE. - ISSN 0342-4642. - 44:3(2018), pp. 337-344. [10.1007/s00134-017-5043-2]
			
	Tutti gli autori
	
						Vincent, Jean-Louis; Lefrant, Jean-Yves; Kotfis, Katarzyna; Nanchal, Rahul; Martin-Loeches, Ignacio; Wittebole, Xavier; Sakka, Samir G.; Pickkers, Pet...espandi
						
	Tipologia
	
				Articolo su rivista

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