To assess ampicillin levels according to the duration of intrapartum antibiotic prophylaxis (IAP).
Objective To assess ampicillin levels according to the duration of intrapartum antibiotic prophylaxis (IAP). Design Prospective cohort single-centre study. Setting Tertiary care centre (Modena, Italy). Patients 120 neonatesâ¥35 weeks' gestation exposed to IAP. Interventions Neonates were divided into four groups, according to the duration of IAP prior to delivery: group 1 (n=30; <1 hour), group 2 (n=30; â¥1 and <2 hours), group 3 (n=30; â¥2 and <4 hours) and group 4 (n=30; â¥2 doses, â¥4 hours). Main outcome measures Blood samples were collected at delivery (from the umbilical cord) and at age 4 hours (from a peripheral vessel). Results Median duration of IAP was 121 min (range 7-2045 min). Median ampicillin levels in umbilical cord blood were 10.4 μg/mL (IQR 6.4-14.9) and in peripheral blood were 4.7 μg/mL (IQR 2.8-6.4μg/mL). Umbilical cord blood levels reached a peak approximately 30 min after IAP and then declined significantly (p<0.001). Peripheral blood levels did not differ among study groups. Neonates exposed to a full loading dose (n=115) had peripheral blood levels 2.5-70 times higher than the minimal inhibitory concentration for group B streptococcus. There was no relationship between neonatal ampicillin concentrations and the duration of IAP prior to delivery (β=â '0.0003, 95% CI â '0.02 to 0.001, p=0.680). Conclusions Ampicillin levels reach a peak in the umbilical cord blood within 30 min of intrapartum administration. After a full loading dose, bactericidal levels persist for at least 4 hours after birth and seem independent of the duration of IAP prior to delivery.
Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates / Berardi, Alberto; Pietrangiolillo, Zaira; Bacchi Reggiani, Maria Letizia; Bianco, Valentina; Gallesi, Daniela; Rossi, Katia; Facchinetti, Fabio; Ferrari, Fabrizio. - In: ARCHIVES OF DISEASE IN CHILDHOOD. FETAL AND NEONATAL EDITION. - ISSN 1359-2998. - 103:2(2018), pp. F152-F156.
Data di pubblicazione: | 2018 |
Data di prima pubblicazione: | 29-giu-2017 |
Titolo: | Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates |
Autore/i: | Berardi, Alberto; Pietrangiolillo, Zaira; Bacchi Reggiani, Maria Letizia; Bianco, Valentina; Gallesi, Daniela; Rossi, Katia; Facchinetti, Fabio; Ferrari, Fabrizio |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1136/archdischild-2016-312546 |
Rivista: | |
Volume: | 103 |
Fascicolo: | 2 |
Pagina iniziale: | F152 |
Pagina finale: | F156 |
Codice identificativo ISI: | WOS:000428893100013 |
Codice identificativo Scopus: | 2-s2.0-85025157393 |
Codice identificativo Pubmed: | 28663282 |
Citazione: | Are postnatal ampicillin levels actually related to the duration of intrapartum antibiotic prophylaxis prior to delivery? A pharmacokinetic study in 120 neonates / Berardi, Alberto; Pietrangiolillo, Zaira; Bacchi Reggiani, Maria Letizia; Bianco, Valentina; Gallesi, Daniela; Rossi, Katia; Facchinetti, Fabio; Ferrari, Fabrizio. - In: ARCHIVES OF DISEASE IN CHILDHOOD. FETAL AND NEONATAL EDITION. - ISSN 1359-2998. - 103:2(2018), pp. F152-F156. |
Tipologia | Articolo su rivista |
File in questo prodotto:
File | Descrizione | Tipologia | |
---|---|---|---|
Ampicillina concentraz postnatali (Berardi et al, ADC FN Ed 2017).pdf | Articolo principale | Versione dell'editore (versione pubblicata) | Administrator Richiedi una copia |

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris