Background: Iron overload disorders are hereditary hemochromatosis and secondary etiologies other than hereditary hemochromatosis. We describe 2 boys presenting with iron overload. Juvenile hemochromatosis and nonalcoholic steatohepatitis (NASH) related iron overload are the genetic and secondary causes, respectively. Observations: Both patients benefited from phlebotomy even if they had different etiologies. Conclusions: In childhood, the diagnosis of iron overload syndromes is crucial because they do not confront us with obvious symptoms and findings. Early initiation of a phlebotomy program can prevent mortality. NASH might lead to iron overload and iron overload might aggravate the clinical course of NASH.

Iron Overload in the Liver of 2 Children: Nonalcoholic Steatohepatitis and Juvenile Hemochromatosis / Ünlüsoy Aksu, Aysel; Caleffi, Angela; Pietrangelo, Antonello; Sari, Sinan; Eǧritaş Gürkan, Ödül; Demirtaş, Zeliha; Yilmaz, Güldal; Dalgiç, Buket. - In: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. - ISSN 1077-4114. - 39:6(2017), pp. 466-469. [10.1097/MPH.0000000000000752]

Iron Overload in the Liver of 2 Children: Nonalcoholic Steatohepatitis and Juvenile Hemochromatosis

Pietrangelo, Antonello;
2017

Abstract

Background: Iron overload disorders are hereditary hemochromatosis and secondary etiologies other than hereditary hemochromatosis. We describe 2 boys presenting with iron overload. Juvenile hemochromatosis and nonalcoholic steatohepatitis (NASH) related iron overload are the genetic and secondary causes, respectively. Observations: Both patients benefited from phlebotomy even if they had different etiologies. Conclusions: In childhood, the diagnosis of iron overload syndromes is crucial because they do not confront us with obvious symptoms and findings. Early initiation of a phlebotomy program can prevent mortality. NASH might lead to iron overload and iron overload might aggravate the clinical course of NASH.
2017
39
6
466
469
Iron Overload in the Liver of 2 Children: Nonalcoholic Steatohepatitis and Juvenile Hemochromatosis / Ünlüsoy Aksu, Aysel; Caleffi, Angela; Pietrangelo, Antonello; Sari, Sinan; Eǧritaş Gürkan, Ödül; Demirtaş, Zeliha; Yilmaz, Güldal; Dalgiç, Buket. - In: JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. - ISSN 1077-4114. - 39:6(2017), pp. 466-469. [10.1097/MPH.0000000000000752]
Ünlüsoy Aksu, Aysel; Caleffi, Angela; Pietrangelo, Antonello; Sari, Sinan; Eǧritaş Gürkan, Ödül; Demirtaş, Zeliha; Yilmaz, Güldal; Dalgiç, Buket
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1153679
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