Intralesional (incision) biopsy for melanoma diagnosis can be warranted for large lesions or for those lesions whose in-toto excision leads to cosmetic and/or functional impairment. However, this diagnostic approach carries a risk of underdiagnosis, if a clinicopathologic diagnostic approach is not implemented. As a rule, in large pigmented lesions from special body areas (scalp and acral skin), clinicodermoscopic differential diagnosis of melanoma includes non-melanocytic skin lesions, traumatic skin changes, and nevi. The unique indication to incision biopsy for the differential diagnosis between nevus and melanoma is a relatively small nodular proliferation developing within a medium-large congenital nevus.
Intralesional (incision) biopsy for melanoma diagnosis: The rules and the exception / Moscarella, Elvira; Argenziano, Giuseppe; Moreno, Claudia; Piana, Simonetta; Lallas, Aimilios; Lombardi, Mara; Longo, Caterina; Ferrara, Gerardo. - In: GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA. - ISSN 0392-0488. - 152:6(2017), pp. 658-662. [10.23736/S0392-0488.16.05376-1]
Intralesional (incision) biopsy for melanoma diagnosis: The rules and the exception
Moscarella, Elvira;Argenziano, Giuseppe;Longo, Caterina;Ferrara, Gerardo
2017
Abstract
Intralesional (incision) biopsy for melanoma diagnosis can be warranted for large lesions or for those lesions whose in-toto excision leads to cosmetic and/or functional impairment. However, this diagnostic approach carries a risk of underdiagnosis, if a clinicopathologic diagnostic approach is not implemented. As a rule, in large pigmented lesions from special body areas (scalp and acral skin), clinicodermoscopic differential diagnosis of melanoma includes non-melanocytic skin lesions, traumatic skin changes, and nevi. The unique indication to incision biopsy for the differential diagnosis between nevus and melanoma is a relatively small nodular proliferation developing within a medium-large congenital nevus.Pubblicazioni consigliate
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