Brain diseases and injuries are growing to be one of the most deadly and costly medical conditions in the world. Unfortunately, current treatments are incapable of ameliorating the symptoms let alone curing the diseases. Many brain diseases have been linked to a loss of function in a protein or enzyme, increasing research for improving their delivery. This is no easy task due to the delicate nature of proteins and enzymes in biological conditions, as well as the many barriers that exist in the body ranging from those in circulation to the more specific barriers to enter the brain. Several main techniques are being used (physical delivery, protein/enzyme conjugates, and nanoparticle delivery) to overcome these barriers and create new therapeutics. This review will cover recently published data and highlights the benefits and deficits of possible new protein or enzyme therapeutics for brain diseases.

Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders / Duskey, Jason T.; Belletti, Daniela; Pederzoli, Francesca; Vandelli, Maria Angela; Forni, Flavio; Ruozi, Barbara; Tosi, Giovanni. - 137:(2017), pp. 29-45. [10.1016/bs.irn.2017.08.006]

Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders

Duskey, Jason T.;Belletti, Daniela;Pederzoli, Francesca;Vandelli, Maria Angela;Forni, Flavio;Ruozi, Barbara;Tosi, Giovanni
2017

Abstract

Brain diseases and injuries are growing to be one of the most deadly and costly medical conditions in the world. Unfortunately, current treatments are incapable of ameliorating the symptoms let alone curing the diseases. Many brain diseases have been linked to a loss of function in a protein or enzyme, increasing research for improving their delivery. This is no easy task due to the delicate nature of proteins and enzymes in biological conditions, as well as the many barriers that exist in the body ranging from those in circulation to the more specific barriers to enter the brain. Several main techniques are being used (physical delivery, protein/enzyme conjugates, and nanoparticle delivery) to overcome these barriers and create new therapeutics. This review will cover recently published data and highlights the benefits and deficits of possible new protein or enzyme therapeutics for brain diseases.
16-ott-2017
NANOMEDICINE IN CENTRAL NERVOUS SYSTEM INJURY AND REPAIR
978-0-12-812381-2
ELSEVIER ACADEMIC PRESS INC
Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders / Duskey, Jason T.; Belletti, Daniela; Pederzoli, Francesca; Vandelli, Maria Angela; Forni, Flavio; Ruozi, Barbara; Tosi, Giovanni. - 137:(2017), pp. 29-45. [10.1016/bs.irn.2017.08.006]
Duskey, Jason T.; Belletti, Daniela; Pederzoli, Francesca; Vandelli, Maria Angela; Forni, Flavio; Ruozi, Barbara; Tosi, Giovanni
File in questo prodotto:
File Dimensione Formato  
uncorrected proof Duskey et al.pdf

accesso aperto

Tipologia: Pre-print dell'autore (bozza pre referaggio)
Dimensione 604.43 kB
Formato Adobe PDF
604.43 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1152651
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 17
social impact