Brain diseases and injuries are growing to be one of the most deadly and costly medical conditions in the world. Unfortunately, current treatments are incapable of ameliorating the symptoms let alone curing the diseases. Many brain diseases have been linked to a loss of function in a protein or enzyme, increasing research for improving their delivery. This is no easy task due to the delicate nature of proteins and enzymes in biological conditions, as well as the many barriers that exist in the body ranging from those in circulation to the more specific barriers to enter the brain. Several main techniques are being used (physical delivery, protein/enzyme conjugates, and nanoparticle delivery) to overcome these barriers and create new therapeutics. This review will cover recently published data and highlights the benefits and deficits of possible new protein or enzyme therapeutics for brain diseases.
Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders / Duskey, Jason T.; Belletti, Daniela; Pederzoli, Francesca; Vandelli, Maria Angela; Forni, Flavio; Ruozi, Barbara; Tosi, Giovanni. - 137(2017), pp. 29-45. [10.1016/bs.irn.2017.08.006]
Data di pubblicazione: | 2017 | |
Titolo: | Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders | |
Autore/i: | Duskey, Jason T.; Belletti, Daniela; Pederzoli, Francesca; Vandelli, Maria Angela; Forni, Flavio; Ruozi, Barbara; Tosi, Giovanni | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/bs.irn.2017.08.006 | |
Codice identificativo Scopus: | 2-s2.0-85031406920 | |
Codice identificativo ISI: | WOS:000435715800002 | |
Codice identificativo Pubmed: | 29132540 | |
Titolo del libro: | NANOMEDICINE IN CENTRAL NERVOUS SYSTEM INJURY AND REPAIR | |
ISBN: | 978-0-12-812381-2 | |
Editore: | ELSEVIER ACADEMIC PRESS INC | |
Citazione: | Current Strategies for the Delivery of Therapeutic Proteins and Enzymes to Treat Brain Disorders / Duskey, Jason T.; Belletti, Daniela; Pederzoli, Francesca; Vandelli, Maria Angela; Forni, Flavio; Ruozi, Barbara; Tosi, Giovanni. - 137(2017), pp. 29-45. [10.1016/bs.irn.2017.08.006] | |
Data di prima pubblicazione: | 16-ott-2017 | |
Tipologia | Capitolo/Saggio |
File in questo prodotto:
File | Descrizione | Tipologia | |
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uncorrected proof Duskey et al.pdf | Pre-print dell'autore (bozza pre referaggio) | Open Access Visualizza/Apri |
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