The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus / Spindler, Volker; Eming, Rüdiger; Schmidt, Enno; Amagai, Masayuki; Grando, Sergei; Jonkman, Marcel F.; Kowalczyk, Andrew P.; Müller, Eliane J.; Payne, Aimee S.; Pincelli, Carlo; Sinha, Animesh A.; Sprecher, Eli; Zillikens, Detlef; Hertl, Michael; Waschke, Jens. - In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - ISSN 0022-202X. - 138:1(2018), pp. 32-37. [10.1016/j.jid.2017.06.022]

Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

Pincelli, Carlo
Membro del Collaboration Group
;
2018

Abstract

The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.
2018
14-ott-2017
138
1
32
37
Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus / Spindler, Volker; Eming, Rüdiger; Schmidt, Enno; Amagai, Masayuki; Grando, Sergei; Jonkman, Marcel F.; Kowalczyk, Andrew P.; Müller, Eliane J.; Payne, Aimee S.; Pincelli, Carlo; Sinha, Animesh A.; Sprecher, Eli; Zillikens, Detlef; Hertl, Michael; Waschke, Jens. - In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - ISSN 0022-202X. - 138:1(2018), pp. 32-37. [10.1016/j.jid.2017.06.022]
Spindler, Volker; Eming, Rüdiger; Schmidt, Enno; Amagai, Masayuki; Grando, Sergei; Jonkman, Marcel F.; Kowalczyk, Andrew P.; Müller, Eliane J.; Payne, Aimee S.; Pincelli, Carlo; Sinha, Animesh A.; Sprecher, Eli; Zillikens, Detlef; Hertl, Michael; Waschke, Jens
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1152599
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