Considering the widespread use of assisted reproductive techniques (ART), DNA methylation of specific genes involved in spermatogenesis achieves increasingly clinical relevance, representing a possible explanation of increased incidence of syndromes related to genomic imprinting in medically assisted pregnancies. Several trials suggested a relationship between male sub-fertility and sperm DNA methylation, although its weight on seminal parameters alteration is still a matter of debate. To evaluate whether aberrant sperm DNA methylation of imprinted genes is associated with impaired sperm parameters. Meta-analysis of controlled clinical trials evaluating imprinted genes sperm DNA methylation comparing men with idiopathic infertility to fertile controls. Twenty-four studies were included, allowing a meta-analytic evaluation for H19, MEST, SNRPN, and LINE-1. When a high heterogeneity of the results was demonstrated, the random effect model was used. H19 methylation levels resulted significantly lower in 879 infertile compared with 562 fertile men (7.53%, 95% CI: 5.14â9.93%, pÂ
Impairment of sperm DNA methylation in male infertility: a meta-analytic study / Santi, D.; De Vincentis, S.; Magnani, E.; Spaggiari, G.. - In: ANDROLOGY. - ISSN 2047-2919. - 5:4(2017), pp. 695-703.
Data di pubblicazione: | 2017 |
Titolo: | Impairment of sperm DNA methylation in male infertility: a meta-analytic study |
Autore/i: | Santi, D.; De Vincentis, S.; Magnani, E.; Spaggiari, G. |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1111/andr.12379 |
Rivista: | |
Volume: | 5 |
Fascicolo: | 4 |
Pagina iniziale: | 695 |
Pagina finale: | 703 |
Codice identificativo ISI: | WOS:000406930900012 |
Codice identificativo Scopus: | 2-s2.0-85024386524 |
Codice identificativo Pubmed: | 28718528 |
Citazione: | Impairment of sperm DNA methylation in male infertility: a meta-analytic study / Santi, D.; De Vincentis, S.; Magnani, E.; Spaggiari, G.. - In: ANDROLOGY. - ISSN 2047-2919. - 5:4(2017), pp. 695-703. |
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