OBJECTIVE - Various observational and randomized studies have demonstrated a reduction in the incidence of type 2 diabetes in postmenopausal women who received estrogen orally. No studies have been performed on the incidence of type 2 diabetes in postmenopausal women treated with transdermal 17-Î²-estradiol. The purpose of our study was to assess the influence of transdermal 17-Î²-estradiol on the incidence of type 2 diabetes in a population of healthy, nonobese postmenopausal women. RESEARCH DESIGN AND METHODS - Between January 1998 and December 2002, 673 healthy, nonobese postmenopausal women (mean age 54 Â± 5 years) were enrolled: 144 (21.4%) of these took transdermal 17-Î²-estradiol and 529 (78.6%) had never taken hormones during their postmenopausal period. Final elaboration of the data took place in July 2003, with a mean follow-up of 3.7 Â± 0.7 years (ranging from 0.5 to 5 years). RESULTS - Type 2 diabetes developed in 60 patients during the follow-up period, which is the equivalent of 22 cases per 1,000 women-years. In the "hormones nonusers" group, diabetes developed in 10% (54 of 529 women; equivalent of 26.5 cases/1,000 women-years), whereas in the "hormones users" group, diabetes developed in 4.16% (6 of 144 women; equivalent of 12.1 cases/1,000 women-years). Transdermal 17-Î²-estradiol emerged as a treatment that significantly reduced the risk of developing diabetes (RR 2.19, 95% CI 1.79-3.56; P = 0.006). CONCLUSIONS - Our results suggest a significant reduction in the incidence of type 2 diabetes in our population of nonobese, healthy postmenopausal women who used transdermal 17-Î²-estradiol. This could suggest that, in some women, the estrogen deficiency that occurs after menopause could represent a fundamental step in the process of diabetogenesis.
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|Data di pubblicazione:||2004|
|Titolo:||Transdermal 17-Î²-Estradiol and Risk of Developing Type 2 Diabetes in A Population of Healthy, Nonobese Postmenopausal Women|
|Autori:||Rossi, Rosario; Origliani, Giorgia; Modena, Maria G.|
|Digital Object Identifier (DOI):||10.2337/diacare.27.3.645|
|Appare nelle tipologie:||Articolo su rivista|
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