Hypertension is the most common chronic disease in industrialized countries and represents the most common major cardiovascular risk factor after the fifth decade of life in both men and women. The prevalence of hypertension is lower in premenopausal women than men, whereas in postmenopausal women it is higher than in men. Mechanisms responsible for the increase in blood pressure are complex and multifactorial, including loss of estrogen, oxidative stress, endothelial dysfunction, modification in renin-angiotensin system spillover and sympathetic activation. In addition, postmenopausal hypertension can be considered an isolated disease, more typical of elderly women, or part of the metabolic syndrome, which is indeed more common in early postmenopausal women. In particular, metabolic syndrome may be considered a potentially unfavourable prognostic factor in hypertensive postmenopausal women, because it seems to worsen the severity of hypertension and reduce the capacity to respond to specific treatments. © 2011 Adis Data Information BV. All rights reserved.

Hypertension in postmenopausal women: Pathophysiology and treatment / Leuzzi, Chiara; Modena, Maria Grazia. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - 18:1(2011), pp. 13-18. [10.2165/11588030-000000000-00000]

Hypertension in postmenopausal women: Pathophysiology and treatment

Leuzzi, Chiara;Modena, Maria Grazia
2011

Abstract

Hypertension is the most common chronic disease in industrialized countries and represents the most common major cardiovascular risk factor after the fifth decade of life in both men and women. The prevalence of hypertension is lower in premenopausal women than men, whereas in postmenopausal women it is higher than in men. Mechanisms responsible for the increase in blood pressure are complex and multifactorial, including loss of estrogen, oxidative stress, endothelial dysfunction, modification in renin-angiotensin system spillover and sympathetic activation. In addition, postmenopausal hypertension can be considered an isolated disease, more typical of elderly women, or part of the metabolic syndrome, which is indeed more common in early postmenopausal women. In particular, metabolic syndrome may be considered a potentially unfavourable prognostic factor in hypertensive postmenopausal women, because it seems to worsen the severity of hypertension and reduce the capacity to respond to specific treatments. © 2011 Adis Data Information BV. All rights reserved.
2011
18
1
13
18
Hypertension in postmenopausal women: Pathophysiology and treatment / Leuzzi, Chiara; Modena, Maria Grazia. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - 18:1(2011), pp. 13-18. [10.2165/11588030-000000000-00000]
Leuzzi, Chiara; Modena, Maria Grazia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1148649
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