Objective: Severe carotid stenosis is a frequent cause of stroke in both men and women. Whereas several sex-related comparisons are available on coronary atherosclerosis, there are few data appraising gender-specific features of carotid plaques. We aimed to systematically compare the pathology and inflammatory features of carotid plaques in men vs women. Methods: Carotid plaque specimens were collected from patients undergoing surgical endarterectomy for asymptomatic or symptomatic carotid stenosis. Histologic analysis was performed, as well as measurements of plaque composition and inflammation. Results: A total of 457 patients were included (132 women, 325 men). Baseline analyses showed a greater prevalence of hypercholesterolemia, hypertension, and former smoking status in women, despite a higher Framingham Heart Score in men (all P <.05). Women had a lower prevalence of thrombotic plaques, smaller percentage area of necrotic core, and hemorrhage extension (all P <.05). Plaque inflammation analysis showed a lower concentration of inflammatory and, in particular, of macrophage foam cells in the plaque cap of women (both P <.05). These differences were, however, no longer significant at multivariable analysis, including several baseline features, such as symptom status and stenosis severity. Conclusions: Carotid plaques seem significantly different in women and men, but the main drivers of such pathologic differences are baseline features, including stenosis severity and symptom status. Â© 2013 Society for Vascular Surgery.
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|Data di pubblicazione:||2013|
|Titolo:||Sex-related differences in carotid plaque features and inflammation|
|Autori:||Sangiorgi, Giuseppe; Roversi, Sara*; Biondi Zoccai, Giuseppe; Modena, Maria Grazia; Servadei, Francesca; Ippoliti, Arnaldo; Mauriello, Alessandro|
|Digital Object Identifier (DOI):||10.1016/j.jvs.2012.07.052|
|Appare nelle tipologie:||Articolo su rivista|
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