Mucosal delivery of inactivated vaccine against respiratory diseases offers several advantages over the traditional intramuscular injection. This requires the use of a potent adjuvant and/or of delivery systems to obtain strong local and systemic immune responses. Site-directed mutagenesis has allowed the generation of mutants such as LTK63 (Ser to Lys substitution at position 63 in the A subunit) and LTR72 (Ala to Arg at position 72) with abolished or strongly reduced toxicity while still retaining strong mucosal adjuvanticity. Both of them have been used to formulate a subunit influenza vaccine, administered intranasally together with nanoparticles and were shown to be able to potentiate its immunogenicity. These vaccine formulations were totally safe in different animal models. © 2004, Elsevier B.V.
Safety and immunogenicity in animals of subunit influenza vaccine given intranasally with mutants of Escherichia coli heat-labile enterotoxin (LT) / Baudner, Barbara C; Peppoloni, Samuele; Ruggiero, Paolo; Contorni, Mario; Morandi, Maurizio; Pizza, Mariagrazia; Podda, Audino; Rappuoli, Rino; Del Giudice, Giuseppe. - In: INTERNATIONAL CONGRESS SERIES. - ISSN 0531-5131. - 1263:C(2004), pp. 640-643. [10.1016/j.ics.2004.02.068]
Safety and immunogenicity in animals of subunit influenza vaccine given intranasally with mutants of Escherichia coli heat-labile enterotoxin (LT)
PEPPOLONI, Samuele;
2004
Abstract
Mucosal delivery of inactivated vaccine against respiratory diseases offers several advantages over the traditional intramuscular injection. This requires the use of a potent adjuvant and/or of delivery systems to obtain strong local and systemic immune responses. Site-directed mutagenesis has allowed the generation of mutants such as LTK63 (Ser to Lys substitution at position 63 in the A subunit) and LTR72 (Ala to Arg at position 72) with abolished or strongly reduced toxicity while still retaining strong mucosal adjuvanticity. Both of them have been used to formulate a subunit influenza vaccine, administered intranasally together with nanoparticles and were shown to be able to potentiate its immunogenicity. These vaccine formulations were totally safe in different animal models. © 2004, Elsevier B.V.Pubblicazioni consigliate
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