The study of 87 adults of different ages, including 15 centenarians, selected for their healthy status, showed that profound changes of humoral immunity occur throughout life. In particular, a statistically significant age-related increase of the serum level of immunoglobulin classes (IgG and IgA but not IgM) and IgG subclasses (IgG1, 2 and 3, but not IgG4) was detected. A parallel age-related decrease of circulating B cells was also observed. The hypothesis of a complex derangement of B cell function and/or compartmentalization with age is put forward, together with the proposal that healthy centenarians (as representative of successful ageing) may be helpful in identifying the physiological age-related modifications of the immune system.

CHANGES IN CIRCULATING B-CELLS AND IMMUNOGLOBULIN CLASSES AND SUBCLASSES IN A HEALTHY AGED POPULATION / Paganelli, R; Quinti, I; Fagiolo, U; Cossarizza, Andrea; Ortolani, C; Guerra, E; Sansoni, P; Pucillo, Lp; Scala, E; Cozzi, E; Bertollo, L; Monti, D; Franceschi, C.. - In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. - ISSN 0009-9104. - STAMPA. - 90:(1992), pp. 351-354.

CHANGES IN CIRCULATING B-CELLS AND IMMUNOGLOBULIN CLASSES AND SUBCLASSES IN A HEALTHY AGED POPULATION

COSSARIZZA, Andrea;
1992-01-01

Abstract

The study of 87 adults of different ages, including 15 centenarians, selected for their healthy status, showed that profound changes of humoral immunity occur throughout life. In particular, a statistically significant age-related increase of the serum level of immunoglobulin classes (IgG and IgA but not IgM) and IgG subclasses (IgG1, 2 and 3, but not IgG4) was detected. A parallel age-related decrease of circulating B cells was also observed. The hypothesis of a complex derangement of B cell function and/or compartmentalization with age is put forward, together with the proposal that healthy centenarians (as representative of successful ageing) may be helpful in identifying the physiological age-related modifications of the immune system.
90
351
354
CHANGES IN CIRCULATING B-CELLS AND IMMUNOGLOBULIN CLASSES AND SUBCLASSES IN A HEALTHY AGED POPULATION / Paganelli, R; Quinti, I; Fagiolo, U; Cossarizza, Andrea; Ortolani, C; Guerra, E; Sansoni, P; Pucillo, Lp; Scala, E; Cozzi, E; Bertollo, L; Monti, D; Franceschi, C.. - In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. - ISSN 0009-9104. - STAMPA. - 90:(1992), pp. 351-354.
Paganelli, R; Quinti, I; Fagiolo, U; Cossarizza, Andrea; Ortolani, C; Guerra, E; Sansoni, P; Pucillo, Lp; Scala, E; Cozzi, E; Bertollo, L; Monti, D; Franceschi, C.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/11415
Citazioni
  • ???jsp.display-item.citation.pmc??? 33
  • Scopus 142
  • ???jsp.display-item.citation.isi??? 127
social impact