In this work a set of novel materials for bone tissue regeneration have been tested in vivo in an animal model. In fact, despite many studies have been devoted to amorphous 45S5 Bioglass®, there is lack in the literature of works aimed to study the in vivo performance of heat-treated – and thus partially crystallized – 45S5. As widely reported, crystallization limits the bioactivity of 45S5 and is the main reason that prevents a broader use of this material. Thus, in the present work, a recently developed bioactive glass (BG_Ca/Mix) is tested, since previous investigations demonstrated that BG_Ca/Mix is particularly promising by virtue of both its high bioactivity and lower tendency to crystallize with respect to 45S5. BG_Ca/Mix sintered powders and two composites, which contain BG_Ca/Mix and an increasing percentage (20 wt% or 70 wt%) of hydroxyapatite (HA), were considered. As a term of comparison, 45S5 sintered powders were also studied. The samples were implanted in rabbits' femurs and harvested after 8 weeks. The histological analysis demonstrated that BG_Ca/Mix has an osteoconductive ability slightly higher than that of 45S5 glass-ceramics, followed by that of the composites, which may represent the starting point for obtaining systems with degradation rate tailored for a given clinical application. Moreover, the 45S5 samples were locally cracked, probably because of a non-uniform dissolution in the physiological environment. On the contrary such cracks, which could lead to implant instability and unsuitable mechanical performance, were not observed in BG_Ca/Mix.
A comparative in vivo evaluation of bioactive glasses and bioactive glass-based composites for bone tissue repair / Bellucci, Devis; Anesi, Alexandre; Salvatori, Roberta; Chiarini, Luigi; Cannillo, Valeria. - In: MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS. - ISSN 0928-4931. - 79(2017), pp. 286-295.
Data di pubblicazione: | 2017 |
Data di prima pubblicazione: | 11-mag-2017 |
Titolo: | A comparative in vivo evaluation of bioactive glasses and bioactive glass-based composites for bone tissue repair |
Autore/i: | Bellucci, Devis; Anesi, Alexandre; Salvatori, Roberta; Chiarini, Luigi; Cannillo, Valeria |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.msec.2017.05.062 |
Rivista: | |
Volume: | 79 |
Pagina iniziale: | 286 |
Pagina finale: | 295 |
Codice identificativo ISI: | WOS:000404704300036 |
Codice identificativo Scopus: | 2-s2.0-85019086501 |
Codice identificativo Pubmed: | 28629020 |
Citazione: | A comparative in vivo evaluation of bioactive glasses and bioactive glass-based composites for bone tissue repair / Bellucci, Devis; Anesi, Alexandre; Salvatori, Roberta; Chiarini, Luigi; Cannillo, Valeria. - In: MATERIALS SCIENCE AND ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS. - ISSN 0928-4931. - 79(2017), pp. 286-295. |
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