Background Radiotherapy is an established treatment for some types of patients with nonmelanoma skin cancer. A hypofractionated schedule has been proposed as a valuable option for elderly disabled patients to minimize the number of hospital visits. Objective We sought to compare a weekly hypofractionated orthovoltage radiotherapy regimen with a standard daily one for the treatment of nonmelanoma skin cancer. Methods A retrospective cohort study was performed on 436 tumors. Overall survival, disease-free survival, and cosmetic outcome were measured. Life-table analysis, Kaplan-Meier survival analysis, and multivariate Cox regression model were performed. Results The hypofractionated regimen was not associated with increased recurrence rates and mortality, or with a poorer cosmetic outcome, when compared with the daily schedule. Limitations Absence of complete information about acute treatment toxicity and a shorter follow-up time for patients receiving the weekly schedule are limitations of this study. Conclusions A weekly hypofractionated regimen of orthovoltage radiotherapy seems to be the most appropriate approach in elderly disabled patients with nonmelanoma skin cancers.

Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules / Pampena, Riccardo; Palmieri, Tamara; Kyrgidis, Athanassios; Ramundo, Dafne; Iotti, Cinzia; Lallas, Aimilios; Moscarella, Elvira; Borsari, Stefania; Argenziano, Giuseppe; Longo, Caterina. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 74:2(2016), pp. 341-347. [10.1016/j.jaad.2015.09.031]

Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules

Pampena, Riccardo;RAMUNDO, Dafne;MOSCARELLA, ELVIRA;BORSARI, Stefania;ARGENZIANO, GIUSEPPE;LONGO, Caterina
2016

Abstract

Background Radiotherapy is an established treatment for some types of patients with nonmelanoma skin cancer. A hypofractionated schedule has been proposed as a valuable option for elderly disabled patients to minimize the number of hospital visits. Objective We sought to compare a weekly hypofractionated orthovoltage radiotherapy regimen with a standard daily one for the treatment of nonmelanoma skin cancer. Methods A retrospective cohort study was performed on 436 tumors. Overall survival, disease-free survival, and cosmetic outcome were measured. Life-table analysis, Kaplan-Meier survival analysis, and multivariate Cox regression model were performed. Results The hypofractionated regimen was not associated with increased recurrence rates and mortality, or with a poorer cosmetic outcome, when compared with the daily schedule. Limitations Absence of complete information about acute treatment toxicity and a shorter follow-up time for patients receiving the weekly schedule are limitations of this study. Conclusions A weekly hypofractionated regimen of orthovoltage radiotherapy seems to be the most appropriate approach in elderly disabled patients with nonmelanoma skin cancers.
14-nov-2015
74
2
341
347
Orthovoltage radiotherapy for nonmelanoma skin cancer (NMSC): Comparison between 2 different schedules / Pampena, Riccardo; Palmieri, Tamara; Kyrgidis, Athanassios; Ramundo, Dafne; Iotti, Cinzia; Lallas, Aimilios; Moscarella, Elvira; Borsari, Stefania; Argenziano, Giuseppe; Longo, Caterina. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 74:2(2016), pp. 341-347. [10.1016/j.jaad.2015.09.031]
Pampena, Riccardo; Palmieri, Tamara; Kyrgidis, Athanassios; Ramundo, Dafne; Iotti, Cinzia; Lallas, Aimilios; Moscarella, Elvira; Borsari, Stefania; Argenziano, Giuseppe; Longo, Caterina
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1140959
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