The incorporation of affinity baits into N-isopropylacrylamide-hydrogel- based nanoparticles offers a novel technology that addresses the major analytical challenges of disease biomarker discovery. In solution in complex biologic fluids (e.g. blood or urine), core-shell bait-containing nanoparticles can perform three functions in one step: (a) sieve molecules according to size, (b) sequestrate and concentrate target analytes, and (c) protect analytes from degradation. © 2009 The Royal Society of Chemistry 2009.
Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery / Luchini, Alessandra; Longo, Caterina; Espina, Virginia; Petricoin Iii, Emanuel F.; Liotta, Lance A.. - In: JOURNAL OF MATERIALS CHEMISTRY. - ISSN 0959-9428. - 19:29(2009), pp. 5071-5077. [10.1039/b822264a]
Nanoparticle technology: Addressing the fundamental roadblocks to protein biomarker discovery
LONGO, Caterina;
2009
Abstract
The incorporation of affinity baits into N-isopropylacrylamide-hydrogel- based nanoparticles offers a novel technology that addresses the major analytical challenges of disease biomarker discovery. In solution in complex biologic fluids (e.g. blood or urine), core-shell bait-containing nanoparticles can perform three functions in one step: (a) sieve molecules according to size, (b) sequestrate and concentrate target analytes, and (c) protect analytes from degradation. © 2009 The Royal Society of Chemistry 2009.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
