Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF

Pokorney, Sean D; Piccini, Jonathan P.; Stevens, Susanna R.; Patel, Manesh R.; Pieper, Karen S.; Halperin, Jonathan L.; Breithardt, Günter; Singer, Daniel E.; Hankey, Graeme J.; Hacke, Werner; Becker, Richard C.; Berkowitz, Scott D.; Nessel, Christopher C.; Mahaffey, Kenneth W.; Fox, Keith A. A.; Califf, Robert M.; Anderson, J.; Bedwell, N.; Bilsker, M.; Bruce, G.; Agah, R.; Desantis, M.; Eisenberg, S.; Flores, A.; Herzog, W.; Klein, S.; Snyder, H.; Krueger, S.; Almaguer, E.; Lavie, E.; Lee, C.; Mallis, G.; Modi, M.; Woodworth, G.; Niazi, I.; Peart, B.; Sundaram, S.; Snoddy, B.; Sotolongo, R.; Moloney, J.; Vijayaraghavan, K.; Whittier, F.; Yellen, L.; Banerjee, S.; Lustgarten, D.; Suresh, D.; Gelernt, M.; Levinson, L.; Ghanekar, R.; Niazi, I.; Kneller, G.; Hall, C.; Fadl, Y.; Suresh, D.; Pirwitz, M.; French, W.; Mayer, N.; Pugeda, J.; Steel, K.; Mody, F.; Malik, A.; Chandna, H.; Go, A.; Emlein, G.; Bowden, W.; Moscoso, R.; Hodson, R.; Berk, M.; Pan, D.; Pappas, J.; Orchard, R.; Lynchard, G.; Vijay, N.; Khan, W.; El Khadra, M.; Antonishen, M.; Cucher, F.; Staab, M.; Zebrack, J.; Borromeo, S.; Heilman, J.; Chaturvedi, S.; Makam, S.; Turk, S.; Hyers, T.; Williams, G.; Labroo, A.; Gill, S.; Myears, D.; Weinstein, J.; Shanes, J.; Chandrashekhar, Y.; Shah, S.; Reiter, W.; Logemann, T.; Almquist, A.; Bhagwat, R.; Tak, T.; Shen Ling, J.; Patel, P.; Artis, A.; Arouni, A.; Lauer, M.; Kinney, K.; Elsen, J.; Roan, P.; Villafria, R.; Sumpter, M.; Ip, J.; Welka, S.; Schifferdecker, B.; Sandoval, R.; Speirs, S.; Jones, A.; Haldis, T.; Kazmierski, J.; Sutherland, J.; Dietrich, D.; Telfer, E.; Berry, J.; Mcelveen, A.; Russell, J.; Sackett, M.; Antonios, N.; Smith, D.; Vora, K.; Kirby, A.; Lui, H.; Mego, D.; Ziada, K.; Navas, J.; Taussig, A.; Koren, M.; Vogel, C.; Saba, F.; Parrott, C.; Schneider, R.; Shirwany, A.; Rubin, M.; Treasure, C.; Bertolet, B.; Chang, M.; Langberg, J.; Becker, R.; Cohen, Y.; Mcgrew, F.; White, J.; Arzola, F.; Zelenka, J.; Tannenbaum, A.; Fernandes, V.; Jamnadas, P.; Agamasu, J.; Collins, B.; Jauch, W.; Sasseen, B.; Hotchkiss, D.; Abadier, R.; Osunkoya, A.; Schlau, A.; Chappel, C.; Foster, M.; Braun, E.; Mostel, E.; Capo, J.; Ashchi, M.; Howard, V.; Albirini, A.; Burger, A.; Rolston, D.; Staniloae, C.; Bacon, J.; Wiseman, A.; Mcgarvey, J.; Sonel, A.; Hamroff, G.; Chang, D.; Daboul, N.; Broderick, G.; Meholick, A.; Corbelli, J.; Silverman, R.; Raffetto, J.; Fishberg, R.; Georgeson, S.; Held, J.; Seidner, M.; Saint Jacques, H.; Heitner, J.; Kutalek, S.; Friedlander, I.; Hutchinson, B.; Walia, J.; Kondo, N.; Smiley, N.; Blitz, L.; Dale, H.; Sulman, S.; Szulawski, I.; Modares, F.; Martin, R.; Nahhas, A.; Renzi, M.; Akyea Djamson, A.; Alfieri, A.; Sandhu, J.; Voyce, S.; Amaram, S.; Meyerrose, G.; Shoukfeh, M.; Lee, F.; Villegas, B.; Idowu, O.; Khera, A.; Sam, C.; Vo, A.; Lieber, I.; Smith, T.; Awan, N.; Tsai, C.; Ganim, R.; Alzaghrini, G.; Pitt, W.; Shepherd, A.; Tang, S.; Go, A.; Stoltz, S.; Nelson, W.; Cox, S.; Meymandi, S.; Melucci, M.; Thomas, G.; Gogia, H.; Machell, C.; Chandrasekaran, S.; Brown, C.; Jetty, P.; Miller, G.; Dykstra, G.; Jaffrani, N.; Zakhary, B.; Caruso, A.; Zolty, R.; Fox, D.; Jacobs, G.; Lebenthal, M.; Mukherjee, S.; Zimetbaum, P.; Kingsley, J.; Jones, R.; Robinson, V.; Kenton, D.; Usedom, J.; Williams, S.; Snipes, C.; Wilson, V.; 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Maung, T.; Wong, F.; Gillis, G.; Vexler, R.; Goldberg, B.; Luterman, M.; Gould, D.; Coutu, B.; Ouellet, A.; Macdonald, P.; Jones, M.; Collette, R.; Chong, P.; Fargher, T.; St Maurice, F.; Fortin, C.; Chehayeb, R.; Proulx, G.; Roy, R.; Liutkus, J.; Syan, G.; Rupka, D.; Lichtenstein, T.; Kooy, J.; Papastergiou, D.; Lubelsky, B.; Doyle, W.; Rajakumar, A.; Cha, J.; Choudhry, A.; Bhamjee, H.; Mawji, A.; Durfresne, M.; Constance, C.; Mutrie, J.; Najarali, A.; Warren, R.; Mucha, M.; Borts, D.; Nord, P.; Carrier, S.; Dawood, M.; Sabe Affaki, G.; Archibald, J.; Abram, N.; Teitelbaum, E.; Ebrahim, I.; Siebert, R.; Van Zyl, L.; Theron, H.; Lloyd, E.; Sommers, R.; Podgorski, G.; Steingo, L.; Dalby, A.; Bayat, J.; Herbst, L.; Bester, F.; Corbett, C.; Bennett, J.; Roodt, A.; Roux, J.; Abelson, M.; Mohamed, Z.; Nortje, H.; Da Silva, A.; Nikolaides, K.; Liagkas, K.; Papasteriadis, E.; Achimastos, A.; Koliopoulos, N.; Trikas, A.; Manolis, A.; Ruiter, J.; Basart, D.; Crijns, H.; Withagen, A.; Janssen, M.; 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Cihalik, C.; Janota, T.; Janousek, J.; Bouchal, P.; Spacek, R.; Choi Siruckova, J.; Heinc, P.; Vojtisek, P.; Pirchala, M.; Malecha, J.; Padour, F.; Linhart, A.; Mandysova, E.; Jandik, J.; Zidkova, E.; Sipula, D.; Ostadal, P.; Polasek, R.; Stransky, V.; Marcinek, G.; Rysava, D.; Osmancik, P.; Huber, K.; Drexel, H.; Brainin, M.; Eichinger Hasenauer, S.; Lang, W.; Pilger, E.; Moriarty, A.; Hudson, I.; Tang, K.; Cleland, J.; Macwalter, R.; Cooke, J.; Mcinnes, G.; Durairaj, R.; Macleod, M.; Murdoch, D.; Kadr, H.; Lip, G.; Andrews, R.; Hunt, B.; Jackson, P.; Macleod, M.; Roffe, C.; Syed, H.; Bath, P.; Coyle, J.; Kelly, D.; Stender, S.; Torppedersen, C.; Tuxen, C.; Jensen, G.; Melchior, T.; Klarlund, K.; Dahlstrom, C.; Nielsen, T.; Nielsen, E.; Bronnum Schou, J.; Sykulski, R.; Blomstrom, P.; Lindholm, C.; Wallen, T.; Nilsson, C.; Bertholds, E.; Carlsater, J.; Sirnes, P.; Elle, S.; Risberg, K.; Furuseth, K.; Skag, A.; Hoivik, H.; Landmark, N.; Kjaernli, T.; Berg Johansen, J.; Gradek, G.; Drzewiecki, A.; Pluta, W.; Szwed, H.; Trusz Gluza, M.; Ogorek, M.; Loboz Grudzien, K.; Ruszkowski, P.; Sciborski, R.; Kopaczewski, J.; Jaworska, K.; Kubica, J.; Opolski, G.; Hoffman, A.; Krzciuk, M.; Sinkiewicz, W.; Piotrowski, W.; Kolodziej, P.; Goszczynska, M.; Rynkiewicz, A.; Chojnowska, L.; Lewczuk, J.; Biedrzycka, M.; Piepiorka, M.; Kowal, J.; Karczmarczyk, A.; Pruszczyk, P.; Tendera, M.; Gaciong, Z.; Krzeminska Pakula, M.; Kornacewicz Jach, Z.; Kania, G.; Brachmann, J.; Lawall, H.; Guelker, H.; Spitzer, S.; Moebiuswinkler, S.; Dempfle, C.; Bode, C.; Darius, H.; Genth Zotz, S.; Sommer, S.; Roehnisch, J.; Strasser, R.; Daenschel, W.; Schwencke, C.; Vom Dahl, J.; Meuser, M.; Behrens Spandau, S.; Behrens Humbold, S.; Muegge, A.; Schoen, N.; Grooterhorst, P.; Ebert, H.; Kraemer, A.; Kohler, B.; Taggeselle, J.; Claus, G.; Sarnighausen, H.; Al Zoebi, A.; Schroeder, T.; Weissbrodt, M.; Lange, R.; Gabelmann, M.; Kaeaeb, S.; Doerr, M.; Boscher, D.; Bosch, R.; Sonntag, F.; Bauknecht, C.; Omran, H.; Leicht, M.; Veltkamp, R.; Hohensee, H.; Dieckmann, H.; Winkelmann, B.; Bernhardt, P.; Schnabel, A.; Kadel, C.; Proskynitopoulos, N.; Seidl, K.; Schellong, S.; Rios, C.; Guevara, C.; Coloma, R.; Torrejon, H.; Parra Galvan, J.; Drago Silva, J.; Gallegos, J.; Mendoza, A.; Negron, S.; Watanabe, L.; Medina, F.; Virgen Carrilo, L.; Alvarez Lopez, H.; Rodriguez, I.; Leiva Pons, J.; Baños Velasco, A.; Villarreal Careaga, J.; De Los Rios, M.; Alcocer Gamba, M.; Llamas Esperon, G.; Villeda, E.; Ahuad Guerrero, A.; Alvariqueta, A.; Amuchastegui, M.; Bluguermann, J.; Caime, G.; Cuneo, C.; Gabito, A.; Garcia Brasca, D.; Hominal, M.; Jure, H.; Luquez, H.; Montana, O.; Piskorz, D.; Listorti, S.; Serra, J.; Sessa, H.; Varini, S.; Vita, N.; Aiub, J.; Mackinnon, I.; Chekherdemian, S.; Castagnino, J.; Cimbaro Canella, J.; Sgammini, H.; Escudero, A.; Albina, G.; Rapallo, C.; Balparda, C.; Chahin, M.; Fuentealba, V.; Riccitelli, M.; Casabe, J.; Lobo Marquez, L.; Kevorkian, R.; Cuadrado, J.; Dran, R.; Muntaner, J.; Gonzalez, M.; Cartasegna, L.; Hasbani, E.; Hrabar, A.; Sanchez, A.; Vogel, D.; Hershson, A.; Avezum, A.; Jaber, J.; Ernesto Leaes, P.; Bozza, A.; Lorga Filho, A.; Pimentel Filho, P.; Moura Jorge, J.; Maia, L.; Manenti, E.; D'Aurea Mora, R.; De Souza Neto, J.; Precoma, D.; Rabelo, A.; Rocha, J.; Rossi, P.; Kerr Saraiva, J.; Zimerman, L.; Bodanese, L.; Figueiredo, E.; De Souza, W. Sebba Barroso; Braga, J.; Alessi, S.; Gomes, M.; Silva, R.; Teixeira, M.; Costa, F.; Motta, M.; Sobral Filho, D.; Reis, G.; Garbelini, B.; Zimmermann, S.; Pereira Barretto, A.; Dohmann, H.; Barreto Filho, J.; Ghorayeb, N.; Borelli, F.; Rossi Dos Santos, F.; Lopes Prudente, M.; Vejar, M.; Lanas, F.; Del Pino, R.; Potthoff, S.; Charme, G.; Aguirre, A.; Saldana, A.; Garces, E.; Bunster, L.; Figueroa, H.; Olivares, C.; Raffo, C.; Vergara, E.; Sepulveda, P.; Jano, G.; Morales Alvarado, J.; Suarez, R.; Urina, M.; Perez, G.; Quintero, A.; Pava, L.; Botero Lopez, R.; Luengas, C.; Hernandez, E.; Sanchez, D.; Poveda, C.; Coronel, J.; Beltran, R.; Jaramillo, C.; Pardo, J.; Ponte Negretti, C.; Isea, J.; Vergara, G.; Morr, I.; Sim, K.; Wan Ahmad, W.; Yusof, Z.; Rosman, A.; Basri, H.; Thompson, P.; Jeffery, P.; Purnell, I.; Roberts Thomson, P.; Heddle, W.; Waites, J.; Walters, D.; Amerena, J.; Challa, P.; Karrasch, J.; Lowy, A.; Fitzpatrick, D.; Parsons, M.; Phan, T.; Karrasch, J.; Karrasch, J.; Bladin, C.; Donnan, G.; Aroney, G.; Gerraty, R.; Anderson, C.; Blombery, P.; Martin, P.; Tissa Wijeratne, K.; Cross, D.; Crimmins, D.; Packham, D.; Jackson, D.; Chua, W.; Merino, R.; Magno, M.; Tirador, L.; Batalla, E.; Manalo, C.; Uy, N.; Ebo, G.; Reyes, E.; Bernan, A.; Richards, M.; Hart, H.; Mann, S.; Fisher, R.; Stewart, R.; Wilkins, G.; Barber, A.; Tan, R.; Ong, H.; Singh, R.; Sukonthasarn, A.; Tanomsup, S.; Krittayaphong, R.; Piamsomboon, C.; Piyayotai, D.; Sunsaneewitayakul, B.; Baek, S.; Seo, H.; Rim, S.; Kim, C.; Kim, K.; Ryu, K.; Jo, S.; Tahk, S.; Lee, H.; Kim, C.; Kim, Y.; Shin, D.; Choi, Y.; Chung, N.; Namgung, J.; Kim, C.; Hong, T.; Shin, W.; Jin, S.; Yan, X.; Fu, G.; Lu, G.; Yang, K.; Xu, D.; Chen, J.; Liu, J.; Wu, S.; Song, J.; Liao, Y.; Xu, B.; Li, Z.; Ma, S.; Yin, Y.; Zhao, Y.; Hu, D.; Ma, C.; Ma, J.; Sun, J.; Li, H.; Hong, X.; Yu, B.; Lu, Q.; Yang, J.; Wu, Z.; Li, Y.; Huang, Y.; Wang, Y.; Liu, M.; Cheng, Y.; Yang, T.; Chen, K.; Wang, H.; Yuan, Z.; Wang, J.; Zeng, Z.; Chen, Y.; Yavuzgil, O.; Kozan, O.; Etemoglu, M.; Diker, E.; Belgi, A.; Ceyhan, C.; Cin, V.; Yilmaz, O.; Ata, N.; Altunkeser, B.; Agacdiken Agir, A.; Karadede, A.; Topsakal, R.; Gulati, R.; Madhavan, A.; Jain, S.; Oomman, A.; Janorkar, S.; Kumar, P.; Madhukar Naik, A.; Thacker, H.; Rajasekhar, V.; Reddy, R.; Keshavamurthy, C.; Jain, P.; Gowdappa, B.; Gadkari, M.; Abhyankar, A.; Ramesh Babu, B.; Vydianathan, P.; Sinha, S.; Garg, N.; Rao, S.; Gautam, P.; Chockalingam, K.; Kumbla, M.; Panwar, R.; Banker, D.; Kaste, M.; Jäkälä, P.; Roine, R.; Mihov, A.; Raev, D.; Yordanova, V.; Dimitrova, S.; Benov, H.; Tsanova, V.; Kyolean, M.; Marchev, S.; Stoikov, A.; Zdravkov, N.; Ramshev, K.; Krastev, A.; Stamenova, P.; Angelova, I.; Pencheva, G.; Grigorova, V.; Petrauskiene, B.; Skripkauskiene, I.; Raugaliene, R.; Norkiene, S.; Mazutavicius, R.; Kavoliuniene, A.; Aidietiene, S.; Aganauskiene, J.; Dailydkiene, A.; Marcinkeviciene, J.; Grigoniene, L.; Anusauskiene, J.; Kavaliauskiene, R.; Lizogub, V.; Rudenko, L.; Tseluyko, V.; Voronkov, L.; Sychov, O.; Svyshchenko, Y.; Sirenko, Y.; Serkova, V.; Seredyuk, N.; Pertseva, T.; Netyazhenko, V.; Lishnevska, V.; Kupchynska, O.; Koval, O.; Koshukova, G.; Karpenko, O.; Grishyna, O.; Faynyk, A.; Dzyak, G.; Dyadyk, O.; Yena, L.; Volkov, V.; Rudyk, I.; Kopytsya, M.; Kononenko, L.; Amosova, K.; Zhurba, S.; Kazimirko, V.; Iuzkiv, I.; Shershnyova, O.; Khomazyuk, T.; Batushkin, V.; Vykhovanyuk, I.; Popik, G.; Skrebkov, V.; Skurtov, A.; Mishchenko, T.; Lytvynenko, N.; Sokolova, L.; Vatutin, M.; Shved, M.; Rebrov, B.; Kadina, L.; Vajda, M.; Ursol, G.; Zheleznyy, V.; Vysochanska, T.; Gozhenko, A.; Fan, K.; Ho, D.; Tse, H.; Yu, C.; Wong, L.; Yeh, H.; Pai, P.; Hsieh, I.; Huang, C.; Hsieh, Y.; Yin, W.; Tsai, L.; Huang, T.; Chen, C.; Chiang, F.; Ueng, K.; Charng, M.; Yeh, H.; Marmor, A.; Katz, A.; Butnaru, A.; Lewis, B.; Eldar, M.; Rosenhack, S.; Elias, N.; Koifman, B.; Shochat, M.; Swissa, M.; Zimlichman, R.; Bental, T.; Weiss, A.; Ganam, R.; Elias, M.; Nseir, W.; Oliven, A.; Brenner, B.; Dayan, M.

doi:10.1161/JAHA.115.002197

Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intentionto- treat population. The median age was 73 years, and the mean CHADS2 score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P<0.0001) and age ≥75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P<0.0001) were associated with higher all-cause mortality. Multiple additional characteristics were independently associated with higher mortality, with decreasing creatinine clearance, chronic obstructive pulmonary disease, male sex, peripheral vascular disease, and diabetes being among the most strongly associated (model C-index 0.677). Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, ≈7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival.

Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF / Pokorney, S.D., Piccini, J.P., Stevens, S.R., Patel, M.R., Pieper, K.S., Halperin, J.L., Breithardt, G., Singer, D.E., Hankey, G.J., Hacke, W., Becker, R.C., Berkowitz, S.D., Nessel, C.C., Mahaffey, K.W., Fox, K.A.A., Califf, R.M., Anderson, J., Bedwell, N., Bilsker, M., Bruce, G., et al.. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 5:3(2016), pp. 1-13. [10.1161/JAHA.115.002197]

Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF

Pokorney, Sean D;Piccini, Jonathan P.;Stevens, Susanna R.;Patel, Manesh R.;Pieper, Karen S.;Halperin, Jonathan L.;Breithardt, Günter;Singer, Daniel E.;Hankey, Graeme J.;Hacke, Werner;Becker, Richard C.;Berkowitz, Scott D.;Nessel, Christopher C.;Mahaffey, Kenneth W.;Fox, Keith A. A.;Califf, Robert M.;Anderson, J.;Bedwell, N.;Bilsker, M.;Bruce, G.;Agah, R.;Desantis, M.;Eisenberg, S.;Flores, A.;Herzog, W.;Klein, S.;Snyder, H.;Krueger, S.;Almaguer, E.;Lavie, E.;Lee, C.;Mallis, G.;Modi, M.;Woodworth, G.;Niazi, I.;Peart, B.;Sundaram, S.;Snoddy, B.;Sotolongo, R.;Moloney, J.;Vijayaraghavan, K.;Whittier, F.;Yellen, L.;Banerjee, S.;Lustgarten, D.;Suresh, D.;Gelernt, M.;Levinson, L.;Ghanekar, R.;Niazi, I.;Kneller, G.;Hall, C.;Fadl, Y.;Suresh, D.;Pirwitz, M.;French, W.;Mayer, N.;Pugeda, J.;Steel, K.;Mody, F.;Malik, A.;Chandna, H.;Go, A.;Emlein, G.;Bowden, W.;Moscoso, R.;Hodson, R.;Berk, M.;Pan, D.;Pappas, J.;Orchard, R.;Lynchard, G.;Vijay, N.;Khan, W.;El Khadra, M.;Antonishen, M.;Cucher, F.;Staab, M.;Zebrack, J.;Borromeo, S.;Heilman, J.;Chaturvedi, S.;Makam, S.;Turk, S.;Hyers, T.;Williams, G.;Labroo, A.;Gill, S.;Myears, D.;Weinstein, J.;Shanes, J.;Chandrashekhar, Y.;Shah, S.;Reiter, W.;Logemann, T.;Almquist, A.;Bhagwat, R.;Tak, T.;Shen Ling, J.;Patel, P.;Artis, A.;Arouni, A.;Lauer, M.;Kinney, K.;Elsen, J.;Roan, P.;Villafria, R.;Sumpter, M.;Ip, J.;Welka, S.;Schifferdecker, B.;Sandoval, R.;Speirs, S.;Jones, A.;Haldis, T.;Kazmierski, J.;Sutherland, J.;Dietrich, D.;Telfer, E.;Berry, J.;Mcelveen, A.;Russell, J.;Sackett, M.;Antonios, N.;Smith, D.;Vora, K.;Kirby, A.;Lui, H.;Mego, D.;Ziada, K.;Navas, J.;Taussig, A.;Koren, M.;Vogel, C.;Saba, F.;Parrott, C.;Schneider, R.;Shirwany, A.;Rubin, M.;Treasure, C.;Bertolet, B.;Chang, M.;Langberg, J.;Becker, R.;Cohen, Y.;Mcgrew, F.;White, J.;Arzola, F.;Zelenka, J.;Tannenbaum, A.;Fernandes, V.;Jamnadas, P.;Agamasu, J.;Collins, B.;Jauch, W.;Sasseen, B.;Hotchkiss, D.;Abadier, R.;Osunkoya, A.;Schlau, A.;Chappel, C.;Foster, M.;Braun, E.;Mostel, E.;Capo, J.;Ashchi, M.;Howard, V.;Albirini, A.;Burger, A.;Rolston, D.;Staniloae, C.;Bacon, J.;Wiseman, A.;Mcgarvey, J.;Sonel, A.;Hamroff, G.;Chang, D.;Daboul, N.;Broderick, G.;Meholick, A.;Corbelli, J.;Silverman, R.;Raffetto, J.;Fishberg, R.;Georgeson, S.;Held, J.;Seidner, M.;Saint Jacques, H.;Heitner, J.;Kutalek, S.;Friedlander, I.;Hutchinson, B.;Walia, J.;Kondo, N.;Smiley, N.;Blitz, L.;Dale, H.;Sulman, S.;Szulawski, I.;Modares, F.;Martin, R.;Nahhas, A.;Renzi, M.;Akyea Djamson, A.;Alfieri, A.;Sandhu, J.;Voyce, S.;Amaram, S.;Meyerrose, G.;Shoukfeh, M.;Lee, F.;Villegas, B.;Idowu, O.;Khera, A.;Sam, C.;Vo, A.;Lieber, I.;Smith, T.;Awan, N.;Tsai, C.;Ganim, R.;Alzaghrini, G.;Pitt, W.;Shepherd, A.;Tang, S.;Go, A.;Stoltz, S.;Nelson, W.;Cox, S.;Meymandi, S.;Melucci, M.;Thomas, G.;Gogia, H.;Machell, C.;Chandrasekaran, S.;Brown, C.;Jetty, P.;Miller, G.;Dykstra, G.;Jaffrani, N.;Zakhary, B.;Caruso, A.;Zolty, R.;Fox, D.;Jacobs, G.;Lebenthal, M.;Mukherjee, S.;Zimetbaum, P.;Kingsley, J.;Jones, R.;Robinson, V.;Kenton, D.;Usedom, J.;Williams, S.;Snipes, C.;Wilson, V.;Hasty, R.;Shoemaker, J.;Donahue, M.;Al Saghir, Y.;Thomsen, E.;Yarows, S.;Chastain, S.;Mclaughlin, P.;Wakham, M.;Shrestha, D.;Simmons, J.;Fisher, D.;Seymour, Z.;Frandsen, B.;First, B.;Sharpe, C.;Popeil, L.;Guthrie, R.;Hunter, J.;Alvarado, O.;Sandberg, J.;Gutman, N.;Belber, A.;Arkhipov, M.;Ballyzek, M.;Baranov, A.;Barbarash, O.;Barbarich, V.;Belenky, D.;Berkovich, O.;Bokarev, I.;Boyarkin, M.;Vaniev, S.;Volkova, E.;Gratsiansky, N.;Demin, A.;Zadionchenko, V.;Zateyshchikov, D.;Zrazhevsky, K.;Mazaev, V.;Martynov, A.;Mikhailov, S.;Mkrtchian, V.;Novozhenov, V.;Raskina, T.;Rebrov, A.;Sanina, N.;Simanekov, V.;Sitnikova, M.;Smolenskaya, O.;Stryuk, R.;Storozhakov, G.;Tankhilevich, B.;Tereschenko, S.;Khokhlov, A.;Khrustalev, O.;Chernov, S.;Shvarts, Y.;Shubik, Y.;Shulman, V.;Yakushin, S.;Bugrova, O.;Ivleva, A.;Libis, R.;Khozyainova, N.;Maslov, S.;Baranova, E.;Sherenkov, A.;Libov, I.;Lusov, V.;Chumakova, G.;Kuznetsov, V.;Ryamzina, I.;Reshetko, O.;Boldueva, S.;Alekseeva, N.;Novikova, T.;Dvornikov, V.;Idrisova, E.;Shostak, N.;Yarokhno, N.;Tebloev, K.;Treshkur, T.;Mazurov, V.;Loktin, E.;Sedavnyh, I.;Alexeeva, O.;Yakhontova, P.;Repin, A.;Izmozherova, N.;Kostenko, V.;Fokin, A.;Ketova, G.;Kouz, S.;Leader, R.;Ayala Paredes, F.;Luton, R.;Ma, P.;Pandey, S.;Pesant, Y.;Senior, R.;Vertes, G.;Bell, A.;Crowley, D.;Vizel, S.;Lasko, B.;Landry, D.;Berger, L.;Heath, J.;Bessoudo, R.;Ling, M.;Tellier, G.;Berlingieri, J.;Kafka, H.;Hill, L.;Mazza, G.;O'Mahony, W.;Chilvers, M.;O'Mahony, M.;Newman, D.;Newman, D.;Newman, D.;Silagy, S.;Heffernan, M.;Bennett, M.;Bhesania, T.;Rockman, G.;Ng, K.;Kalra, B.;Meneses, G.;Liang, W.;Cheung, M.;Kozak, J.;Pugen, G.;Vavougios, J.;Kates, M.;Nunes Vaz, C.;Jaffer, S.;Orfi, J.;Faiers, A.;Chung, C.;Felsen, S.;Bergman, S.;Bernstein, I.;Brownscombe, L.;Stockdill, J.;Silver, E.;Ezekiel, D.;Jagan, N.;Khurana, M.;Reisler, H.;Goldman, H.;Maung, T.;Wong, F.;Gillis, G.;Vexler, R.;Goldberg, B.;Luterman, M.;Gould, D.;Coutu, B.;Ouellet, A.;Macdonald, P.;Jones, M.;Collette, R.;Chong, P.;Fargher, T.;St Maurice, F.;Fortin, C.;Chehayeb, R.;Proulx, G.;Roy, R.;Liutkus, J.;Syan, G.;Rupka, D.;Lichtenstein, T.;Kooy, J.;Papastergiou, D.;Lubelsky, B.;Doyle, W.;Rajakumar, A.;Cha, J.;Choudhry, A.;Bhamjee, H.;Mawji, A.;Durfresne, M.;Constance, C.;Mutrie, J.;Najarali, A.;Warren, R.;Mucha, M.;Borts, D.;Nord, P.;Carrier, S.;Dawood, M.;Sabe Affaki, G.;Archibald, J.;Abram, N.;Teitelbaum, E.;Ebrahim, I.;Siebert, R.;van Zyl, L.;Theron, H.;Lloyd, E.;Sommers, R.;Podgorski, G.;Steingo, L.;Dalby, A.;Bayat, J.;Herbst, L.;Bester, F.;Corbett, C.;Bennett, J.;Roodt, A.;Roux, J.;Abelson, M.;Mohamed, Z.;Nortje, H.;Da Silva, A.;Nikolaides, K.;Liagkas, K.;Papasteriadis, E.;Achimastos, A.;Koliopoulos, N.;Trikas, A.;Manolis, A.;Ruiter, J.;Basart, D.;Crijns, H.;Withagen, A.;Janssen, M.;Van Langeveld, R.;van Gelder, I.;Hamer, B.;Van Der Heijden, R.;Hertzeberger, D.;Van Hessen, M.;Pieterse, M.;Groutars, R.;Kuijper, A.;De Ruiter, G.;van Boven, A.;Hoogslag, P.;Kragten, H.;Thijssen, H.;Veldkamp, R.;Scavee, C.;Heidbuchel, H.;Debruyne, P.;Deruyter, B.;El Ali, H.;Goethals, M.;Cytryn, R.;Striekwold, H.;De Wolf, L.;Goethals, P.;Provenier, F.;Hellemans, S.;Galinier, M.;Coisne, D.;Koenig, A.;Galley, D.;Destrac, S.;Leduc, J.;Rifai, A.;Citron, B.;Ellie, E.;Fournier, P.;Steg, G.;Landel, R.;Robinson, A.;Ziegler, F.;Boulliat, J.;Zuber, M.;Vida, M.;Galve Basilio, E.;Lopez, M.;Íñiguez, C.;Iglesias Alonso, L.;Cavero Gibanel, M.;Olivan Martinez, J.;Calvo Iglesias, F.;Marco Vera, P.;Bruguera Cortada, J.;Jaber Houbani, A.;Merino, J.;Olaz Preciado, F.;Balaguer, J.;de la Hera Galarza, J.;Martinez Rubio, A.;Fontcuberta, J.;Sotillo Marti, J.;Gonzalez Juanatey, J.;Del Campo, R.;Vivanco, G.;Alvarez Garcia, P.;Pelayo, M.;Lippai, J.;Zamolyi, K.;Károly, T.;Vertes, A.;Nagy, A.;Kosa, I.;Janosi, A.;Lupkovics, G.;Kalo, E.;Forster, T.;Kis, E.;Tenczer, J.;Bereczki, D.;Komoly, S.;Csanyi, A.;Kiss, R.;Valikovics, A.;Dioszeghy, P.;Masini, F.;Terrosu, P.;Cirrincione, V.;Marabotti, C.;Cosmi, F.;Salvioni, A.;Binetti, G.;Piovaccari, G.;Nassiacos, D.;BORIANI, Giuseppe;Calvi, V.;De Caterina, R.;Pengo, V.;Parati, G.;Carolei, A.;D'Angelo, A.;Di Biase, M.;Fattore, L.;Agnelli, G.;Merlini, P.;Furlan, M.;Rasura, M.;Gandolfo, C.;Ageno, W.;Piovella, F.;Micieli, G.;Cinteza, M.;Fierbinteanu, C.;Natase Melicovici, D.;Ionescu, D.;Macarie, C.;Nanea, I.;Radoi, M.;Tatu Chitoiu, G.;Dragulescu, S.;Tudose, A.;Militaru, C.;Bengus, C.;Ungureanu, G.;Tau, A.;Popa, V.;Pirvu, O.;Bojinca, M.;Sipciu, D.;Popescu, M.;Chiru, M.;Vinereanu, D.;Tudoran, M.;Cojocaru, T.;Vintila, M.;Aron, G.;Petrascu, O.;Bolohan, F.;Baumgartner, R.;Sekoranja, L.;Vojacek, J.;Lacnak, B.;Kellnerova, I.;Dunaj, M.;Cihalik, C.;Janota, T.;Janousek, J.;Bouchal, P.;Spacek, R.;Choi Siruckova, J.;Heinc, P.;Vojtisek, P.;Pirchala, M.;Malecha, J.;Padour, F.;Linhart, A.;Mandysova, E.;Jandik, J.;Zidkova, E.;Sipula, D.;Ostadal, P.;Polasek, R.;Stransky, V.;Marcinek, G.;Rysava, D.;Osmancik, P.;Huber, K.;Drexel, H.;Brainin, M.;Eichinger Hasenauer, S.;Lang, W.;Pilger, E.;Moriarty, A.;Hudson, I.;Tang, K.;Cleland, J.;Macwalter, R.;Cooke, J.;Mcinnes, G.;Durairaj, R.;Macleod, M.;Murdoch, D.;Kadr, H.;Lip, G.;Andrews, R.;Hunt, B.;Jackson, P.;Macleod, M.;Roffe, C.;Syed, H.;Bath, P.;Coyle, J.;Kelly, D.;Stender, S.;Torppedersen, C.;Tuxen, C.;Jensen, G.;Melchior, T.;Klarlund, K.;Dahlstrom, C.;Nielsen, T.;Nielsen, E.;Bronnum Schou, J.;Sykulski, R.;Blomstrom, P.;Lindholm, C.;Wallen, T.;Nilsson, C.;Bertholds, E.;Carlsater, J.;Sirnes, P.;Elle, S.;Risberg, K.;Furuseth, K.;Skag, A.;Hoivik, H.;Landmark, N.;Kjaernli, T.;Berg Johansen, J.;Gradek, G.;Drzewiecki, A.;Pluta, W.;Szwed, H.;Trusz Gluza, M.;Ogorek, M.;Loboz Grudzien, K.;Ruszkowski, P.;Sciborski, R.;Kopaczewski, J.;Jaworska, K.;Kubica, J.;Opolski, G.;Hoffman, A.;Krzciuk, M.;Sinkiewicz, W.;Piotrowski, W.;Kolodziej, P.;Goszczynska, M.;Rynkiewicz, A.;Chojnowska, L.;Lewczuk, J.;Biedrzycka, M.;Piepiorka, M.;Kowal, J.;Karczmarczyk, A.;Pruszczyk, P.;Tendera, M.;Gaciong, Z.;Krzeminska Pakula, M.;Kornacewicz Jach, Z.;Kania, G.;Brachmann, J.;Lawall, H.;Guelker, H.;Spitzer, S.;Moebiuswinkler, S.;Dempfle, C.;Bode, C.;Darius, H.;Genth Zotz, S.;Sommer, S.;Roehnisch, J.;Strasser, R.;Daenschel, W.;Schwencke, C.;vom Dahl, J.;Meuser, M.;Behrens Spandau, S.;Behrens Humbold, S.;Muegge, A.;Schoen, N.;Grooterhorst, P.;Ebert, H.;Kraemer, A.;Kohler, B.;Taggeselle, J.;Claus, G.;Sarnighausen, H.;Al Zoebi, A.;Schroeder, T.;Weissbrodt, M.;Lange, R.;Gabelmann, M.;Kaeaeb, S.;Doerr, M.;Boscher, D.;Bosch, R.;Sonntag, F.;Bauknecht, C.;Omran, H.;Leicht, M.;Veltkamp, R.;Hohensee, H.;Dieckmann, H.;Winkelmann, B.;Bernhardt, P.;Schnabel, A.;Kadel, C.;Proskynitopoulos, N.;Seidl, K.;Schellong, S.;Rios, C.;Guevara, C.;Coloma, R.;Torrejon, H.;Parra Galvan, J.;Drago Silva, J.;Gallegos, J.;Mendoza, A.;Negron, S.;Watanabe, L.;Medina, F.;Virgen Carrilo, L.;Alvarez Lopez, H.;Rodriguez, I.;Leiva Pons, J.;Baños Velasco, A.;Villarreal Careaga, J.;De los Rios, M.;Alcocer Gamba, M.;Llamas Esperon, G.;Villeda, E.;Ahuad Guerrero, A.;Alvariqueta, A.;Amuchastegui, M.;Bluguermann, J.;Caime, G.;Cuneo, C.;Gabito, A.;Garcia Brasca, D.;Hominal, M.;Jure, H.;Luquez, H.;Montana, O.;Piskorz, D.;Listorti, S.;Serra, J.;Sessa, H.;Varini, S.;Vita, N.;Aiub, J.;Mackinnon, I.;Chekherdemian, S.;Castagnino, J.;Cimbaro Canella, J.;Sgammini, H.;Escudero, A.;Albina, G.;Rapallo, C.;Balparda, C.;Chahin, M.;Fuentealba, V.;Riccitelli, M.;Casabe, J.;Lobo Marquez, L.;Kevorkian, R.;Cuadrado, J.;Dran, R.;Muntaner, J.;Gonzalez, M.;Cartasegna, L.;Hasbani, E.;Hrabar, A.;Sanchez, A.;Vogel, D.;Hershson, A.;Avezum, A.;Jaber, J.;Ernesto Leaes, P.;Bozza, A.;Lorga Filho, A.;Pimentel Filho, P.;Moura Jorge, J.;Maia, L.;Manenti, E.;D'Aurea Mora, R.;de Souza Neto, J.;Precoma, D.;Rabelo, A.;Rocha, J.;Rossi, P.;Kerr Saraiva, J.;Zimerman, L.;Bodanese, L.;Figueiredo, E.;de Souza, W. Sebba Barroso;Braga, J.;Alessi, S.;Gomes, M.;Silva, R.;Teixeira, M.;Costa, F.;Motta, M.;Sobral Filho, D.;Reis, G.;Garbelini, B.;Zimmermann, S.;Pereira Barretto, A.;Dohmann, H.;Barreto Filho, J.;Ghorayeb, N.;Borelli, F.;Rossi dos Santos, F.;Lopes Prudente, M.;Vejar, M.;Lanas, F.;Del Pino, R.;Potthoff, S.;Charme, G.;Aguirre, A.;Saldana, A.;Garces, E.;Bunster, L.;Figueroa, H.;Olivares, C.;Raffo, C.;Vergara, E.;Sepulveda, P.;Jano, G.;Morales Alvarado, J.;Suarez, R.;Urina, M.;Perez, G.;Quintero, A.;Pava, L.;Botero Lopez, R.;Luengas, C.;Hernandez, E.;Sanchez, D.;Poveda, C.;Coronel, J.;Beltran, R.;Jaramillo, C.;Pardo, J.;Ponte Negretti, C.;Isea, J.;Vergara, G.;Morr, I.;Sim, K.;Wan Ahmad, W.;Yusof, Z.;Rosman, A.;Basri, H.;Thompson, P.;Jeffery, P.;Purnell, I.;Roberts Thomson, P.;Heddle, W.;Waites, J.;Walters, D.;Amerena, J.;Challa, P.;Karrasch, J.;Lowy, A.;Fitzpatrick, D.;Parsons, M.;Phan, T.;Karrasch, J.;Karrasch, J.;Bladin, C.;Donnan, G.;Aroney, G.;Gerraty, R.;Anderson, C.;Blombery, P.;Martin, P.;Tissa Wijeratne, K.;Cross, D.;Crimmins, D.;Packham, D.;Jackson, D.;Chua, W.;Merino, R.;Magno, M.;Tirador, L.;Batalla, E.;Manalo, C.;Uy, N.;Ebo, G.;Reyes, E.;Bernan, A.;Richards, M.;Hart, H.;Mann, S.;Fisher, R.;Stewart, R.;Wilkins, G.;Barber, A.;Tan, R.;Ong, H.;Singh, R.;Sukonthasarn, A.;Tanomsup, S.;Krittayaphong, R.;Piamsomboon, C.;Piyayotai, D.;Sunsaneewitayakul, B.;Baek, S.;Seo, H.;Rim, S.;Kim, C.;Kim, K.;Ryu, K.;Jo, S.;Tahk, S.;Lee, H.;Kim, C.;Kim, Y.;Shin, D.;Choi, Y.;Chung, N.;Namgung, J.;Kim, C.;Hong, T.;Shin, W.;Jin, S.;Yan, X.;Fu, G.;Lu, G.;Yang, K.;Xu, D.;Chen, J.;Liu, J.;Wu, S.;Song, J.;Liao, Y.;Xu, B.;Li, Z.;Ma, S.;Yin, Y.;Zhao, Y.;Hu, D.;Ma, C.;Ma, J.;Sun, J.;Li, H.;Hong, X.;Yu, B.;Lu, Q.;Yang, J.;Wu, Z.;Li, Y.;Huang, Y.;Wang, Y.;Liu, M.;Cheng, Y.;Yang, T.;Chen, K.;Wang, H.;Yuan, Z.;Wang, J.;Zeng, Z.;Chen, Y.;Yavuzgil, O.;Kozan, O.;Etemoglu, M.;Diker, E.;Belgi, A.;Ceyhan, C.;Cin, V.;Yilmaz, O.;Ata, N.;Altunkeser, B.;Agacdiken Agir, A.;Karadede, A.;Topsakal, R.;Gulati, R.;Madhavan, A.;Jain, S.;Oomman, A.;Janorkar, S.;Kumar, P.;Madhukar Naik, A.;Thacker, H.;Rajasekhar, V.;Reddy, R.;Keshavamurthy, C.;Jain, P.;Gowdappa, B.;Gadkari, M.;Abhyankar, A.;Ramesh Babu, B.;Vydianathan, P.;Sinha, S.;Garg, N.;Rao, S.;Gautam, P.;Chockalingam, K.;Kumbla, M.;Panwar, R.;Banker, D.;Kaste, M.;Jäkälä, P.;Roine, R.;Mihov, A.;Raev, D.;Yordanova, V.;Dimitrova, S.;Benov, H.;Tsanova, V.;Kyolean, M.;Marchev, S.;Stoikov, A.;Zdravkov, N.;Ramshev, K.;Krastev, A.;Stamenova, P.;Angelova, I.;Pencheva, G.;Grigorova, V.;Petrauskiene, B.;Skripkauskiene, I.;Raugaliene, R.;Norkiene, S.;Mazutavicius, R.;Kavoliuniene, A.;Aidietiene, S.;Aganauskiene, J.;Dailydkiene, A.;Marcinkeviciene, J.;Grigoniene, L.;Anusauskiene, J.;Kavaliauskiene, R.;Lizogub, V.;Rudenko, L.;Tseluyko, V.;Voronkov, L.;Sychov, O.;Svyshchenko, Y.;Sirenko, Y.;Serkova, V.;Seredyuk, N.;Pertseva, T.;Netyazhenko, V.;Lishnevska, V.;Kupchynska, O.;Koval, O.;Koshukova, G.;Karpenko, O.;Grishyna, O.;Faynyk, A.;Dzyak, G.;Dyadyk, O.;Yena, L.;Volkov, V.;Rudyk, I.;Kopytsya, M.;Kononenko, L.;Amosova, K.;Zhurba, S.;Kazimirko, V.;Iuzkiv, I.;Shershnyova, O.;Khomazyuk, T.;Batushkin, V.;Vykhovanyuk, I.;Popik, G.;Skrebkov, V.;Skurtov, A.;Mishchenko, T.;Lytvynenko, N.;Sokolova, L.;Vatutin, M.;Shved, M.;Rebrov, B.;Kadina, L.;Vajda, M.;Ursol, G.;Zheleznyy, V.;Vysochanska, T.;Gozhenko, A.;Fan, K.;Ho, D.;Tse, H.;Yu, C.;Wong, L.;Yeh, H.;Pai, P.;Hsieh, I.;Huang, C.;Hsieh, Y.;Yin, W.;Tsai, L.;Huang, T.;Chen, C.;Chiang, F.;Ueng, K.;Charng, M.;Yeh, H.;Marmor, A.;Katz, A.;Butnaru, A.;Lewis, B.;Eldar, M.;Rosenhack, S.;Elias, N.;Koifman, B.;Shochat, M.;Swissa, M.;Zimlichman, R.;Bental, T.;Weiss, A.;Ganam, R.;Elias, M.;Nseir, W.;Oliven, A.;Brenner, B.;Dayan, M.

2016

Abstract

Background-Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. Methods and Results-In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (ROCKET AF) study, patients with nonvalvular atrial fibrillation were randomized to rivaroxaban or dose-adjusted warfarin. Cox proportional hazards regression with backward elimination identified factors at randomization that were independently associated with all-cause mortality in the 14 171 participants in the intentionto- treat population. The median age was 73 years, and the mean CHADS2 score was 3.5. Over 1.9 years of median follow-up, 1214 (8.6%) patients died. Kaplan-Meier mortality rates were 4.2% at 1 year and 8.9% at 2 years. The majority of classified deaths (1081) were cardiovascular (72%), whereas only 6% were nonhemorrhagic stroke or systemic embolism. No significant difference in all-cause mortality was observed between the rivaroxaban and warfarin arms (P=0.15). Heart failure (hazard ratio 1.51, 95% CI 1.33-1.70, P<0.0001) and age ≥75 years (hazard ratio 1.69, 95% CI 1.51-1.90, P<0.0001) were associated with higher all-cause mortality. Multiple additional characteristics were independently associated with higher mortality, with decreasing creatinine clearance, chronic obstructive pulmonary disease, male sex, peripheral vascular disease, and diabetes being among the most strongly associated (model C-index 0.677). Conclusions-In a large population of patients anticoagulated for nonvalvular atrial fibrillation, ≈7 in 10 deaths were cardiovascular, whereas <1 in 10 deaths were caused by nonhemorrhagic stroke or systemic embolism. Optimal prevention and treatment of heart failure, renal impairment, chronic obstructive pulmonary disease, and diabetes may improve survival.

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Scheda completa

Scheda completa (DC)

	Anno di pubblicazione
	
				2016
			
	Data di prima pubblicazione
	
				8-mar-2016
			
	Rivista
	
				JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE
			
	N° del Volume
	
				5
			
	Fascicolo
	
				3
			
	Pagina iniziale
	
				1
			
	Pagina finale
	
				13
			
	Codice DOI
	
				https://dx.doi.org/10.1161/JAHA.115.002197
			
	Codice WoS
	
				WOS:000385312200002
			
	Codice Scopus
	
				2-s2.0-85006208431
			
	Codice PubMed
	
				26955859
			
	Citazione
	
				Cause of death and predictors of all-cause mortality in anticoagulated patients with nonvalvular atrial fibrillation: Data from ROCKET AF / Pokorney, S.D., Piccini, J.P., Stevens, S.R., Patel, M.R., Pieper, K.S., Halperin, J.L., Breithardt, G., Singer, D.E., Hankey, G.J., Hacke, W., Becker, R.C., Berkowitz, S.D., Nessel, C.C., Mahaffey, K.W., Fox, K.A.A., Califf, R.M., Anderson, J., Bedwell, N., Bilsker, M., Bruce, G., et al.. - In: JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE. - ISSN 2047-9980. - 5:3(2016), pp. 1-13. [10.1161/JAHA.115.002197]
			
	Tutti gli autori
	
						Pokorney, Sean D; Piccini, Jonathan P.; Stevens, Susanna R.; Patel, Manesh R.; Pieper, Karen S.; Halperin, Jonathan L.; Breithardt, Günter; Singer, Da...espandi
						
	Tipologia
	
				Articolo su rivista

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