Sentinel lymph node biopsy has been proposed as a diagnostic method for estimation of the malignant potential of atypical Spitz tumours. However, although cell deposits are commonly detected in the sentinel lymph nodes of patients with atypical Spitz tumours, their prognosis is substantially better than that of patients with melanoma and positive sentinel lymph node biopsies. We did a systematic review of published reports to assess the role of sentinel lymph node biopsy as a prognostic method in the management of atypical Spitz tumours. The results of our analysis did not show any prognostic benefit of sentinel lymph node biopsy; having a positive sentinel lymph node does not seem to predict a poorer outcome for patients with atypical Spitz tumours. These findings indicate that, especially in the paediatric population, it might be prudent initially to use complete excision with clear margins and careful clinical follow-up in patients with atypical Spitz tumours. © 2014 Elsevier Ltd.

Atypical Spitz tumours and sentinel lymph node biopsy: A systematic review / Lallas, Aimilios; Kyrgidis, Athanassios; Ferrara, Gerardo; Kittler, Harald; Apalla, Zoe; Castagnetti, Fabio; Longo, Caterina; Moscarella, Elvira; Piana, Simonetta; Zalaudek, Iris; Argenziano, Giuseppe. - In: THE LANCET ONCOLOGY. - ISSN 1470-2045. - 15:4(2014), pp. e178-e183. [10.1016/S1470-2045(13)70608-9]

Atypical Spitz tumours and sentinel lymph node biopsy: A systematic review

FERRARA, GERARDO;LONGO, Caterina;MOSCARELLA, ELVIRA;ARGENZIANO, GIUSEPPE
2014

Abstract

Sentinel lymph node biopsy has been proposed as a diagnostic method for estimation of the malignant potential of atypical Spitz tumours. However, although cell deposits are commonly detected in the sentinel lymph nodes of patients with atypical Spitz tumours, their prognosis is substantially better than that of patients with melanoma and positive sentinel lymph node biopsies. We did a systematic review of published reports to assess the role of sentinel lymph node biopsy as a prognostic method in the management of atypical Spitz tumours. The results of our analysis did not show any prognostic benefit of sentinel lymph node biopsy; having a positive sentinel lymph node does not seem to predict a poorer outcome for patients with atypical Spitz tumours. These findings indicate that, especially in the paediatric population, it might be prudent initially to use complete excision with clear margins and careful clinical follow-up in patients with atypical Spitz tumours. © 2014 Elsevier Ltd.
15
4
e178
e183
Atypical Spitz tumours and sentinel lymph node biopsy: A systematic review / Lallas, Aimilios; Kyrgidis, Athanassios; Ferrara, Gerardo; Kittler, Harald; Apalla, Zoe; Castagnetti, Fabio; Longo, Caterina; Moscarella, Elvira; Piana, Simonetta; Zalaudek, Iris; Argenziano, Giuseppe. - In: THE LANCET ONCOLOGY. - ISSN 1470-2045. - 15:4(2014), pp. e178-e183. [10.1016/S1470-2045(13)70608-9]
Lallas, Aimilios; Kyrgidis, Athanassios; Ferrara, Gerardo; Kittler, Harald; Apalla, Zoe; Castagnetti, Fabio; Longo, Caterina; Moscarella, Elvira; Piana, Simonetta; Zalaudek, Iris; Argenziano, Giuseppe
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1140189
Citazioni
  • ???jsp.display-item.citation.pmc??? 35
  • Scopus 103
  • ???jsp.display-item.citation.isi??? 93
social impact