Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701)
The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2 / Huisman, Menno V; Rothman, Kenneth J.; Paquette, Miney; Teutsch, Christine; Diener, Hans Christoph; Dubner, Sergio J.; Halperin, Jonathan L.; Ma, Chang Sheng; Zint, Kristina; Elsaesser, Amelie; Bartels, Dorothee B.; Lip, Gregory Y. H.; Abban, Dzifa; Abdul, Nasser; Abelson, Mark; Ackermann, Alan; Adams, Fran; Adams, Luthando; Adragão, Pedro; Ageno, Walter; Aggarwal, Rajesh; Agosti, Sergio; Marin, Javier Aguila; Aguilar, Francisco; Aguilar Linares, Julio Alberto; Aguinaga, Luis; Ahmad, Zia; Ainsworth, Paul; Al Ghalayini, Kamal; Al Ismail, Saad; Alasfar, Abdelfatah; Alawwa, Abdul; Al Dallow, Raed; Alderson, Lisa; Alexopoulos, Dimitrios; Ali, Abdullah; Ali, Malik; Aliyar, Pareed; Al Joundi, Tammam; Al Mahameed, Soufian; Almassi, Hossein; Almuti, Khalid; Al Obaidi, Mohamed; Alshehri, Mohamed; Altmann, Ute; Alves, Alvaro Rabelo; Al Zoebi, Ayham; Amara, Walid; Amelot, Mathieu; Amjadi, Nima; Ammirati, Fabrizio; Andrawis, Nabil; Angoulvant, Denis; Annoni, Giorgio; Ansalone, Gerardo; Antonescu, Sorin Alexandru; Ariani, Mehrdad; Arias, Juan Carlos; Armero, Sébastien; Arora, Rohit; Arora, Chander; Ashcraft, William; Aslam, M. Shakil; Astesiano, Alfredo; Audouin, Philippe; Augenbraun, Charles; Aydin, S.; Azar, Rabih; Azim, Abul; Aziz, Shahid; Backes, Luciano Marcelo; Baig, Mirza; Bains, Suchdeep; Bakbak, Asaad; Baker, Seth; Bakhtiar, Karim; Bala, Richard; Banayan, Jonathan; Bandh, Stellan; Bando, Shigenobu; Banerjee, Subhash; Bank, Alan; Barbarash, Olga; Barón, Gonzalo; Barr, Craig; Barrera, Carlos; Barton, John; Kes, Vanja Basic; Baula, Giovanni; Bayeh, Hamid; Bazargani, Nooshin; Behrens, Steffen; Bell, Alan; Benezet Mazuecos, Juan; Benhalima, Bouziane; Berdagué, Philippe; Berg van den, B. J.; Bergen van, P. F. M. M.; Berngard, Edvard; Bernstein, Richard; Berrospi, Percy; Berti, Sergio; Bertomeu, Vicente; Berz, Andrea; Bettencourt, Paulo; Betzu, Robert; Beyer Westendorf, Jan; Bhagwat, Ravi; Black, Toby; Blanco Ibaceta, Jorge Hugo; Bloom, Stephen; Blumberg, Edwin; Bo, Mario; Bockisch, Valerie; Bøhmer, Ellen; Bongiorni, Maria Grazia; Boriani, Giuseppe; Bosch, Ralph; Boswijk, D. J.; Bott, Jochen; Bottacchi, Edo; Kalan, Marica Bracic; Brandes, Axel; Bratland, Bjørn; Brautigam, Donald; Breton, Nicolas; Brouwers, P. J. A. M.; Browne, Kevin; Bruguera, Jordi; Brunehaut, Myriam; Brunschwig, Claude; Buathier, Hervé; Buhl, Aurélie; Bullinga, John; Butcher, Kenneth; Cabrera Honorio, Jose Walter; Caccavo, Alberto; Cadinot, Didier; Cai, Shanglang; Calvi, Valeria; Camm, John; Candeias, Rui; Capo, James; Capucci, Alessandro; Cardoso, Juliano Novaes; Duarte Vera, Yan Carlos; Carlson, Brian; Carvalho, Paula; Cary, Susanna; Casanova, Rene; Casu, Gavino; Cattan, Simon; Cavallini, Claudio; Cayla, Guillaume; Cha, Tae Joon; Cha, Kwang Soo; Chaaban, Said; Chae, Jei Keon; Challappa, Krishnan; Chand, Sunil; Chandrashekar, Harinath; Chang, Mark; Charbel, Paul; Chartier, Ludovic; Chatterjee, Kausik; Cheema, Aamir; Chen, Shih Ann; Chevallereau, Pierre; Chiang, Fu Tien; Chiarella, Francesco; Chih Chan, Lin; Cho, Yong Keun; Choi, Dong Ju; Chouinard, Guy; Danny, Null; Chow, Hoi Fan; Chrysos, Dimitrios; Chumakova, Galina; José Roberto Chuquiure Valenzuela, Eduardo Julián; Cieza Lara, Tomas; Nica, Violeta Cindea; Ciobotaru, Vlad; Cislowski, David; Citerne, Olivier; Claus, Matthias; Clay, Anthony; Clifford, Piers; Cohen, Serge; Cohen, Andrew; Colivicchi, Furio; Collins, Rónán; Compton, Steve; Connors, Sean; Conti, Alberto; Buenostro, Gabriel Contreras; Coodley, Gregg; Cooper, Martin; Corbett, Lynn; Corey, Oran; Coronel, Julián; Corrigan, John; Cotrina Pereyra, Rosa Ysabel; Cottin, Yves; Coutu, Benoit; Cracan, Aurel; Crean, Peter; Crenshaw, James; Crijns, H. J. G. M.; Crump, Charles; Cucher, Fred; Cudmore, David; Cui, Lianqun; Culp, John; Darius, Harald; Dary, Patrick; Dascotte, Olivier; Dauber, Ira; Davee, Thomas; Davies, Ruth; Davis, Gershan; Davy, Jean Marc; Dayer, Mark; De La Briolle, Axel; de Mora, Manuel; De Teresa, Eduardo; De Wolf, Luc; Decoulx, Eric; Deepak, Sasalu; Defaye, Pascal; Del Carpio Munoz, Freddy; Brkljacic, Diana Delic; Deluche, Laurent; Destrac, Sylvain; Deumite, N. Joseph; Di Legge, Silvia; Dibon, Olivier; Diemberger, Igor; Dillinger, Jean; Dionísio, Pedro; Naydenov, Stefan; Dotani, Imran; Dotcheva, Elena; D'Souza, Anthony; Dubrey, Simon; Ducrocq, Xavier; Dupljakov, Dmitry; Duthinh, Vuong; Dutra, Oscar Pereira; Dutta, Dipankar; Duvilla, Nathalie; Dy, Johnny; Dziewas, Rainer; Eaton, Charles; Eaves, William; Ebinger, Matthew; Eck van, J. W. M.; Edwards, Tim; Egocheaga, Isabel; Ehrlich, Clifford; Eisenberg, Steven; El Hallak, Abdel; El Jabali, Adnan; El Mahmoud, Rami; El Shahawy, Mahfouz; Eldadah, Zayd; Elghelbazouri, Fouad; Elhag, Omar; El Hamdani, Mehiar; Elias, Darlene; Ellery, Adam; El Sayed, Hassan; Elvan, A.; Erickson, Bernard; Espaliat, Eric; Essandoh, Louis; Everington, Tamara; Evonich, Rudolph; Ezhov, Andrey; Fácila, Lorenzo; Farsad, Ramin; Fayard, Maxime; Fedele, Francesco; Gomes Ferreira, Luis Gustavo; Ferreira, Daniel; Santos, José Ferreira; Ferrier, Anna; Finsen, Alexandra; First, Brian; Fisher, Raymond; Floyd, John; Folk, Thomas; Fonseca, Catarina; Fonseca, Luisa; Forman, Steven; Forsgren, Magnus; Foster, Malcolm; Foster, Nathan; Frais, Michael; Frandsen, Brad; Frappé, Thierry; Freixa, Ramon; French, William; Freydlin, Marina; Frickel, Siegfried; Fruntelata, Ana Gabriela; Fujii, Shigeru; Fujino, Yusuke; Fukunaga, Hiroshi; Furukawa, Yutaka; Gabelmann, Matthias; Gabris, Michael; Gadsbøll, Niels; Galin, Pavel; Galinier, Michel; Ganim, Ricky; Garcia, Ronnie; Quintana, Antonio Garcia; Gartenlaub, Olivier; Genz, Conrad; Georger, Frédéric; Georges, Jean Louis; Georgeson, Steven; Ghanbasha, Ali; Giedrimas, Evaldas; Gierba, Mariusz; Gillespie, Eve; Giniger, Alberto; Gkotsis, Alexandros; Gmehling, Joachim; Gniot, Jacek; Goethals, Peter; Goldberg, Ronald; Goldmann, Britta; Goldscher, David; Golitsyn, Sergey; Gomez Lopez, Efrain Alonso; Gomez Mesa, Juan Esteban; Gonzalez, Efrain; Cocina, Emilio Gonzalez; Juanatey, Carlos Gonzalez; Gorbunov, Vladimir; Gordon, Brian; Gorka, Hervé; Gornick, Charles; Gorog, Diana; Goss, Franz; Götte, Andreas; Goube, Pascal; Goudevenos, Ioannis; Goulden, Dudley; Graham, Brett; Grande, Angel; Greco, Cesare; Green, Martin; Greer, Gerald; Gremmler, Uwe; Grena, Paul; Grinshstein, Yuriy; Grond, Martin; Gronda, Edoardo; Grondin, Francois; Grönefeld, Gerian; Groot de, J. R.; Guardigli, Gabriele; Guarnieri, Thomas; Caiedo, Carolina Guevara; Guignier, Alexandre; Gulizia, Michele; Gumbley, Michael; Gupta, Dhiraj; Hack, Terrence; Haerer, Winfried; Hakas, Joseph; Hall, Christian; Hampsey, James; Hananis, Georgios; Hanbali, Basel; Handel, Franklin; Hargrove, Joe; Hargroves, David; Harris, Kenneth; Hartley, David; Haruna, Tetsuya; Hata, Yoshiki; Hayek, Emil; Healey, Jeff; Hearne, Steven; Heggelund, Geir; Hemels, M. E. 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The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
Huisman, Menno V; Rothman, Kenneth J.; Paquette, Miney; Teutsch, Christine; Diener, Hans Christoph; Dubner, Sergio J.; Halperin, Jonathan L.; Ma, Chang Sheng; Zint, Kristina; Elsaesser, Amelie; Bartels, Dorothee B.; Lip, Gregory Y. H.; Abban, Dzifa; Abdul, Nasser; Abelson, Mark; Ackermann, Alan; Adams, Fran; Adams, Luthando; Adragão, Pedro; Ageno, Walter; Aggarwal, Rajesh; Agosti, Sergio; Marin, Javier Aguila; Aguilar, Francisco; Aguilar Linares, Julio Alberto; Aguinaga, Luis; Ahmad, Zia; Ainsworth, Paul; Al Ghalayini, Kamal; Al Ismail, Saad; Alasfar, Abdelfatah; Alawwa, Abdul; Al Dallow, Raed; Alderson, Lisa; Alexopoulos, Dimitrios; Ali, Abdullah; Ali, Malik; Aliyar, Pareed; Al Joundi, Tammam; Al Mahameed, Soufian; Almassi, Hossein; Almuti, Khalid; Al Obaidi, Mohamed; Alshehri, Mohamed; Altmann, Ute; Alves, Alvaro Rabelo; Al Zoebi, Ayham; Amara, Walid; Amelot, Mathieu; Amjadi, Nima; Ammirati, Fabrizio; Andrawis, Nabil; Angoulvant, Denis; Annoni, Giorgio; Ansalone, Gerardo; Antonescu, Sorin Alexandru; Ariani, Mehrdad; Arias, Juan Carlos; Armero, Sébastien; Arora, Rohit; Arora, Chander; Ashcraft, William; Aslam, M. Shakil; Astesiano, Alfredo; Audouin, Philippe; Augenbraun, Charles; Aydin, S.; Azar, Rabih; Azim, Abul; Aziz, Shahid; Backes, Luciano Marcelo; Baig, Mirza; Bains, Suchdeep; Bakbak, Asaad; Baker, Seth; Bakhtiar, Karim; Bala, Richard; Banayan, Jonathan; Bandh, Stellan; Bando, Shigenobu; Banerjee, Subhash; Bank, Alan; Barbarash, Olga; Barón, Gonzalo; Barr, Craig; Barrera, Carlos; Barton, John; Kes, Vanja Basic; Baula, Giovanni; Bayeh, Hamid; Bazargani, Nooshin; Behrens, Steffen; Bell, Alan; Benezet Mazuecos, Juan; Benhalima, Bouziane; Berdagué, Philippe; Berg van den, B. J.; Bergen van, P. F. M. M.; Berngard, Edvard; Bernstein, Richard; Berrospi, Percy; Berti, Sergio; Bertomeu, Vicente; Berz, Andrea; Bettencourt, Paulo; Betzu, Robert; Beyer Westendorf, Jan; Bhagwat, Ravi; Black, Toby; Blanco Ibaceta, Jorge Hugo; Bloom, Stephen; Blumberg, Edwin; Bo, Mario; Bockisch, Valerie; Bøhmer, Ellen; Bongiorni, Maria Grazia; BORIANI, Giuseppe ;Bosch, Ralph; Boswijk, D. J.; Bott, Jochen; Bottacchi, Edo; Kalan, Marica Bracic; Brandes, Axel; Bratland, Bjørn; Brautigam, Donald; Breton, Nicolas; Brouwers, P. J. A. M.; Browne, Kevin; Bruguera, Jordi; Brunehaut, Myriam; Brunschwig, Claude; Buathier, Hervé; Buhl, Aurélie; Bullinga, John; Butcher, Kenneth; Cabrera Honorio, Jose Walter; Caccavo, Alberto; Cadinot, Didier; Cai, Shanglang; Calvi, Valeria; Camm, John; Candeias, Rui; Capo, James; Capucci, Alessandro; Cardoso, Juliano Novaes; Duarte Vera, Yan Carlos; Carlson, Brian; Carvalho, Paula; Cary, Susanna; Casanova, Rene; Casu, Gavino; Cattan, Simon; Cavallini, Claudio; Cayla, Guillaume; Cha, Tae Joon; Cha, Kwang Soo; Chaaban, Said; Chae, Jei Keon; Challappa, Krishnan; Chand, Sunil; Chandrashekar, Harinath; Chang, Mark; Charbel, Paul; Chartier, Ludovic; Chatterjee, Kausik; Cheema, Aamir; Chen, Shih Ann; Chevallereau, Pierre; Chiang, Fu Tien; Chiarella, Francesco; Chih Chan, Lin; Cho, Yong Keun; Choi, Dong Ju; Chouinard, Guy; Danny, Null; Chow, Hoi Fan; Chrysos, Dimitrios; Chumakova, Galina; José Roberto Chuquiure Valenzuela, Eduardo Julián; Cieza Lara, Tomas; Nica, Violeta Cindea; Ciobotaru, Vlad; Cislowski, David; Citerne, Olivier; Claus, Matthias; Clay, Anthony; Clifford, Piers; Cohen, Serge; Cohen, Andrew; Colivicchi, Furio; Collins, Rónán; Compton, Steve; Connors, Sean; Conti, Alberto; Buenostro, Gabriel Contreras; Coodley, Gregg; Cooper, Martin; Corbett, Lynn; Corey, Oran; Coronel, Julián; Corrigan, John; Cotrina Pereyra, Rosa Ysabel; Cottin, Yves; Coutu, Benoit; Cracan, Aurel; Crean, Peter; Crenshaw, James; Crijns, H. J. G. M.; Crump, Charles; Cucher, Fred; Cudmore, David; Cui, Lianqun; Culp, John; Darius, Harald; Dary, Patrick; Dascotte, Olivier; Dauber, Ira; Davee, Thomas; Davies, Ruth; Davis, Gershan; Davy, Jean Marc; Dayer, Mark; De La Briolle, Axel; de Mora, Manuel; De Teresa, Eduardo; De Wolf, Luc; Decoulx, Eric; Deepak, Sasalu; Defaye, Pascal; Del Carpio Munoz, Freddy; Brkljacic, Diana Delic; Deluche, Laurent; Destrac, Sylvain; Deumite, N. Joseph; Di Legge, Silvia; Dibon, Olivier; Diemberger, Igor; Dillinger, Jean; Dionísio, Pedro; Naydenov, Stefan; Dotani, Imran; Dotcheva, Elena; D'Souza, Anthony; Dubrey, Simon; Ducrocq, Xavier; Dupljakov, Dmitry; Duthinh, Vuong; Dutra, Oscar Pereira; Dutta, Dipankar; Duvilla, Nathalie; Dy, Johnny; Dziewas, Rainer; Eaton, Charles; Eaves, William; Ebinger, Matthew; Eck van, J. W. M.; Edwards, Tim; Egocheaga, Isabel; Ehrlich, Clifford; Eisenberg, Steven; El Hallak, Abdel; El Jabali, Adnan; El Mahmoud, Rami; El Shahawy, Mahfouz; Eldadah, Zayd; Elghelbazouri, Fouad; Elhag, Omar; El Hamdani, Mehiar; Elias, Darlene; Ellery, Adam; El Sayed, Hassan; Elvan, A.; Erickson, Bernard; Espaliat, Eric; Essandoh, Louis; Everington, Tamara; Evonich, Rudolph; Ezhov, Andrey; Fácila, Lorenzo; Farsad, Ramin; Fayard, Maxime; Fedele, Francesco; Gomes Ferreira, Luis Gustavo; Ferreira, Daniel; Santos, José Ferreira; Ferrier, Anna; Finsen, Alexandra; First, Brian; Fisher, Raymond; Floyd, John; Folk, Thomas; Fonseca, Catarina; Fonseca, Luisa; Forman, Steven; Forsgren, Magnus; Foster, Malcolm; Foster, Nathan; Frais, Michael; Frandsen, Brad; Frappé, Thierry; Freixa, Ramon; French, William; Freydlin, Marina; Frickel, Siegfried; Fruntelata, Ana Gabriela; Fujii, Shigeru; Fujino, Yusuke; Fukunaga, Hiroshi; Furukawa, Yutaka; Gabelmann, Matthias; Gabris, Michael; Gadsbøll, Niels; Galin, Pavel; Galinier, Michel; Ganim, Ricky; Garcia, Ronnie; Quintana, Antonio Garcia; Gartenlaub, Olivier; Genz, Conrad; Georger, Frédéric; Georges, Jean Louis; Georgeson, Steven; Ghanbasha, Ali; Giedrimas, Evaldas; Gierba, Mariusz; Gillespie, Eve; Giniger, Alberto; Gkotsis, Alexandros; Gmehling, Joachim; Gniot, Jacek; Goethals, Peter; Goldberg, Ronald; Goldmann, Britta; Goldscher, David; Golitsyn, Sergey; Gomez Lopez, Efrain Alonso; Gomez Mesa, Juan Esteban; Gonzalez, Efrain; Cocina, Emilio Gonzalez; Juanatey, Carlos Gonzalez; Gorbunov, Vladimir; Gordon, Brian; Gorka, Hervé; Gornick, Charles; Gorog, Diana; Goss, Franz; Götte, Andreas; Goube, Pascal; Goudevenos, Ioannis; Goulden, Dudley; Graham, Brett; Grande, Angel; Greco, Cesare; Green, Martin; Greer, Gerald; Gremmler, Uwe; Grena, Paul; Grinshstein, Yuriy; Grond, Martin; Gronda, Edoardo; Grondin, Francois; Grönefeld, Gerian; Groot de, J. R.; Guardigli, Gabriele; Guarnieri, Thomas; Caiedo, Carolina Guevara; Guignier, Alexandre; Gulizia, Michele; Gumbley, Michael; Gupta, Dhiraj; Hack, Terrence; Haerer, Winfried; Hakas, Joseph; Hall, Christian; Hampsey, James; Hananis, Georgios; Hanbali, Basel; Handel, Franklin; Hargrove, Joe; Hargroves, David; Harris, Kenneth; Hartley, David; Haruna, Tetsuya; Hata, Yoshiki; Hayek, Emil; Healey, Jeff; Hearne, Steven; Heggelund, Geir; Hemels, M. E. W.; Hemery, Yann; Henein, Sam; Henz, Benhur; Her, Sung Ho; Hermany, Paul; Hernandes, Mauro Esteves; Higashino, Yorihiko; Hill, Michael; Hisadome, Tetsuo; Hishida, Eiji; Hitchcock, James; Hoffer, Etienne; Hoghton, Matthew; Holmes, Clare; Hong, Suk Keun; Houppe Nousse, Marie Paule; Howard, Victor; Hsu, Li Fern; Huang, Chi Hung; Huckins, David; Huehnergarth, Kier; Huizenga, A.; Huntley, Richard; Hussein, Gamal; Hwang, Gyo Seung; Igbokidi, Oyidie; Iglesias, Ignacio; Ikpoh, Margaret; Imberti, Davide; Ince, Hüseyin; Indolfi, Ciro; Ionova, Tatiana; Ip, John; Irles, Didier; Iseki, Harukazu; Ismail, Younus; Israel, Noah; Isserman, Steven; Iteld, Bruce; Ivanchura, Galina; Iyer, Ramakrishnan; Iyer, Venkat; Iza Villanueva, Ruben Omar; Jackson Voyzey, Ewart; Jaffrani, Naseem; Jäger, Frank; Jain, Manish; James, Martin; Jamon, Yann; Jang, Sung Won; Pereira Jardim, Cesar Augusto; Jarmukli, Nabil; Jeanfreau, Robert; Jenkins, Ronald; Jiang, Xianyan; Jiang, Heng; Jiang, Tiemin; Jiang, Nan; Jimenez, Javier; Jobe, Robert; Joffe, Ian; Johansson, Bengt; Jones, Nick; Moura Jorge, Jose Carlos; Jouve, Bernard; Jundi, Mayar; Jung, Werner; Jung, Byung Chun; Jung, Kyung Tae; Kabbani, Samer; Kabour, Ameer; Kafkala, Chrystalenia; Kajiwara, Koji; Kalinina, Larisa; Kampus, Priit; Kanda, Junji; Kapadia, Shaival; Karim, Amin; Karolyi, Laszlo; Kashou, Hisham; Kastrup, Andreas; Katsivas, Apostolos; Kaufman, Elizabeth; Kawai, Kazuya; Kawajiri, Kenji; Kazmierski, John; Keeling, Phil; Kerfes, Galal Ali; Kerr Saraiva, José Francisco; Ketova, Galina; Khaira, Ajit; Khalid, Muhammad; Khludeeva, Elena; Khripun, Aleksey; Kim, Doo Il; Kim, Dae Kyeong; Kim, Nam Ho; Kim, Ki Seok; Kim, Young Hoon; Kim, Jin bae; Kim, June Soo; Kim, Jeong Su; Kinova, Elena; Klein, Alexander; Kleinschnitz, Christoph; Kmetzo, James; Kneller, G. Larsen; Knezevic, Aleksandar; Koch, Stanley; Koenig, Kai; Angela Koh, Su Mei; Köhrmann, Martin; Koons, Jay; Korabathina, Ravikiran; Korennova, Olga; Koschutnik, Martin; Kosinski, Edward; Kovacic, Dragan; Kowalczyk, Jacek; Koziolova, Natalya; Kragten, J. A.; Krause, Lars Udo; Kreidieh, Imad; Krenning, B. J.; Krishnaswamy, Kannappan; Krysiak, Waldemar; Kuck, Karl Heinz; Kumar, Somnath; Kümler, Thomas; Kuniss, Malte; Kuo, Jen Yuan; Küppers, Achim; Kurrelmeyer, Karla; Kwan, Tak; Kyo, Eisho; Labovitz, Arthur; Lacroix, Alain; Lam, Andy; Lanas Zanetti, Fernando Tomas; Landau, Charles; Landini, Giancarlo; Lang, Wilfried; Larsen, Torben Bjerregaard; Laske, Volker; Lavandier, Karine; Law, Nicki; Lee, Moon Hyoung; Lee, Daniel; Leitão, Ana; Lejay, Dominique; Lelonek, Malgorzata; Lenarczyk, Radoslaw; Leprince, Patrick; Lequeux, Benoit; Leschke, Matthias; Ley, Nicolas; Li, Zicheng; Li, Yansheng; Li, Xiaodong; Li, Zhanquan; Li, Weihua; Liang, Jianqiu; Lieber, Ira; Lillestol, Michael; Limon Rodriguez, Ramon Horacio; Lin, Hailong; Lip, Gregory; Litchfield, Jennifer; Liu, Zhitao; Liu, Xuebo; Liu, Yalin; Liu, Feng; Liu, Wenhui; Llamas Esperon, Guillermo Antonio; Llisterri, Jose Luis; Lo, Ted; Lo, Eric; Lobos, Jose Maria; Lodde, Bernhard Paul; Loiselet, Philippe; López Sendón, José; Lorga Filho, Adalberto Menezes; Lori, Ido; Luo, Ming; Lupovitch, Steven; Lyrer, Philippe; Zuhairy, Hamed M.; Ma, Changsheng; Ma, Genshan; Ma, Hong; Madariaga, Irene; Maeno, Koji; Magnin, Dominique; Mahmood, Shahid; Mahood, Karen; Maid, Gustavo; Mainigi, Sumeet; Makaritsis, Konstantinos; Maldonado Villalon, José Arturo; Malhotra, Rohit; Malik, Amir; Mallecourt, Catherine; Mallik, Rajiv; Manning, Rickey; Manolis, Athanasios; Mantas, Ioannis; Manzur Jattin, Fernando Gabriel; Marcionni, Niccolo'; Marín, Francisco; Santana, Antonio Martín; Martinez, Jorge; Martinez, Luis; Maskova, Petra; Hernández, Norberto Matadamas; Matskeplishvili, Simon; Matsuda, Katsuhiro; Mavri, Alenka; May, Erik; Mayer, Nolan; Mazon, Pilar; Mcclure, John; Mccormack, Terry; Mcgarity, William; Mcguire, Michael; Mcintyre, Hugh; Mclaughlin, Paul; Mclaurin, Brent; Medina Palomino, Feliz Alvaro; Mehta, Paresh; Mehzad, Reza; Meinel, Andreas; Melandri, Francesco; Mena, Amparo; Meno, Hirosi; Menzies, Dhananjai; Metcalf, Kneale; Meyer, Beat; Miarka, Jacek; Mibach, Frank; Michalski, Dominik; Michel, Patrik; Chreih, Rami Mihail; Mikdadi, Ghiath; Mikhail, Magdy; Mikus, Milan; Milicic, Davor; Militaru, Constantin; Miller, Gary; Milonas, Christos; Minescu, Bogdan; Mintale, Iveta; Miralles, Aurélien; Mirault, Tristan; Mistry, Dinesh; Mitchell, George; Miu, Nicoleta Violeta; Miyamoto, Naomasa; Moccetti, Tiziano; Mohammed, Akber; Nor, Azlisham Mohd; Molina de Salazar, Dora Ines; Molon, Giulio; Molony, David; Mondillo, Sergio; Mont, Lluis; Moodley, Rajendra; Moore, Roger; Ribeiro Moreira, Dalmo Antonio; Mori, Kiyoo; Moriarty, Andrew; Morka, Jacek; Moschos, Nikitas; Mota Gomes, Marco Antônio; Mousallem, Nicolas; Moya, Angel; Mügge, Andreas; Mulhearn, Thomas; Muller, Jean Joseph; Muresan, Carmen Manuela; Muse, Derek; Musial, Wlodzimierz; Musumeci, Francesco; Nadar, Venkatesh; Nageh, Thuraia; Nair, Priya; Nakagawa, Hidemitsu; Nakamura, Yuichiro; Nakayama, Toru; Nam, Ki Byeong; Napalkov, Dmitry; Natarajan, Indira; Nayak, Hemal; Nechvatal, Libor; Neiman, James; Nerheim, Pamela; Neuenschwander, Fernando Carvalho; Nishida, Kunihiro; Nizov, Alexey; Novikova, Tatiana; Novo, Salvatore; Nowalany Kozielska, Ewa; Nsah, Emmanuel; Nunez Fragoso, Juan Carlos; Nyvad, Ole; de Los Rios Ibarra, Manuel Odin; O'Donnell, Martin; O'Donnell, Philip; Oh, Dong Jin; Oh, Yong Seog; Daniel Oh, Chia Theng; O'Hara, Gilles; Oikonomou, Kostas; Olalla, Juan Jose; Olivari, Zoran; Oliver, Richard; Olympios, Christoforos; Osborne, John; Osca, Joaquin; Osman, Raed; Osunkoya, Abayomi; Padanilam, Benzy; Panchenko, Elizaveta; Pandey, A. Shekhar; Vicenzo de Paola, Angelo Amato; Paraschos, Alexander; Pardell, Herbert; Park, Hyung Wook; Park, Jong Sung; Parkash, Ratika; Parker, Ian; Parrens, Eric; Parris, Robert; Passamonti, Enrico; Patel, Jaydutt; Patel, Rajesh; Pentz, William H.; Persic, Viktor; Perticone, Francesco; Peters, Patrick; Petkar, Sanjiv; Pezo, Luis Felipe; Pham, David; Cao Phai, Gérald Phan; Phlaum, Stephen; Pineau, Julien; Pineda Velez, Armando; Pini, Riccardo; Pinter, Arnold; Pinto, Fausto; Pirelli, Salvatore; Pivac, Nediljko; Pizzini, Attilia Maria; Pocanic, Darko; Calin Podoleanu, Cristian Gheorghe; Polanczyk, Carisi Anne; Polasek, Petr; Poljakovic, Zdravka; Pollock, Stewart; Polo, Jose; Poock, James; Poppert, Holger; Porro, Yamile; Pose, Antonio; Poulain, François; Poulard, Jean Ernst; Pouzar, Joe; Povolny, Petr; Pozzer, Domingo; Pras, Athanasios; Prasad, Neeraj; Prevot, Sébastien; Protasov, Konstantin; Prunier, Laurent; Puleo, John; Pye, Maurice; Qaddoura, Fatma; Quedillac, Jean Michel; Raev, Dimitar; Rahimi, Sidiqullah; Raisaro, Arturo; Rama, Bhola; Ranadive, Nandkishore; Randall, Katie; Ranjith, Naresh; Raposo, Nuno; Rashid, Haroon; Raters, Christa; Rauch Kroehnert, Ursula; Rebane, Thomas; Regner, Stefan; Renzi, Michael; Reyes Rocha, Miguel Agustin; Reza, Shabbir; Ria, Luigi; Richter, Dimitrios; Rickli, Hans; Rickner, Kyle; Rieker, Werner; Rigo, Fausto; Ripoll, Tomas; Fonteles Ritt, Luiz Eduardo; Roberts, Douglas; Pascual, Carlos Rodríguez; Briones, Ignacio Rodriguez; Reyes, Humberto Rodriguez; Roelke, Marc; Roman, Mark; Romeo, Francesco; Ronner, E.; Ronziere, Thomas; Rooyer, F. A.; Rosenbaum, David; Roth, Sherryn; Rozkova, Nadezda; Rubacek, Miroslav; Rubalcava, Frank; Rubanenko, Olesya; Rubin, Andrew; Borret, Mariano Ruiz; Rybak, Karin; Sabbour, Hani; Morales, Oscar Saenz; Sakai, Tetsuo; Salacata, Abraham; Salecker, Ilsbe; Salem, Adrien; Salfity, Marwan; Salguero, Rafael; Salvioni, Alessandro; Samson, Mercedes; Sanchez, Gregorio; Sandesara, Chirag; Saporito, Wladmir Faustino; Sasaoka, Taishi; Sattar, Payman; Savard, Daniel; Scala, Pierre Jean; Scemama, Jacques; Schaupp, Thierry; Schellinger, Peter; Scherr, Carlos; Schmitz, Karl Heinz; Schmitz, Bettina; Schmitz, Lisa; Schnitzler, Robert; Schnupp, Steffen; Schoeniger, Peter; Schön, Norbert; Schuster, Stefan; Schwimmbeck, Peter; Seamark, Clare; Seebass, Ruediger; Seidl, Karl Heinz; Seidman, Barry; Sek, Jaroslaw; Sekaran, Lakshmanan; Seko, Yoshinori; Sepulveda Varela, Pablo Andres; Sevilla, Begoña; Shah, Vinay; Shah, Anil; Shah, Neerav; Shah, Aman; Shanes, Jeffrey; Sharareh, Ali; Sharma, Vijay Kumar; Shaw, Louise; Shimizu, Yutaka; Shimomura, Hideki; Shin, Dong Gu; Shin, Eun Seok; Shite, Junya; Shoukfeh, Mohammad; Shoultz, Charles; Silver, Frank; Sime, Iveta; Simmers, T. 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S.; Turakhia, Minang; Turk, Samir; Turner, Wayne; Tveit, Arnljot; Twiddy, Shannon; Tytus, Richard; Ukrainski, Gerald; Valdovinos Chavez, Salvador Bruno; Van De Graaff, Eric; Vanacker, Peter; Vardas, Panagiotis; Vargas, Michael; Vassilikos, Vassilios; Vazquez, Juan; Venkataraman, Asok; Verdecchia, Paolo; Vester, Ernst Günter; Vial, Hubert; Vinereanu, Dragos; Vlastaris, Anthony; Vogel, Craig; vom Dahl, Jürgen; von Mering, Matthias; Vora, Kishor; Wakefield, Paul; Walia, Jasjit; Walter, Thomas; Wang, Mingsheng; Wang, Ningfu; Wang, Feng; Wang, Xinhua; Wang, Zulu; Wang, Kuo Yang; Watanabe, Kouki; Wei, Jeanne; Weimar, Christian; Weinrich, Renate; Wen, Ming Shien; Wheelan, Kevin; Wicke, Jens; Wiemer, Marcus; Wild, Beate; Wilke, Andreas; Willems, Stephan; Williams, Marcus; Williams, David; Winkler, Andreas; Wirtz, Jost Henner; Witzenbichler, Bernhard; Wong, Danny H. K.; Lawrence Wong, Ka Sing; Wong, Brian; Wozakowska Kaplon, Beata; Wu, Zhaohui; Wu, Shulin; Wyatt, Nell; Xu, Yong; Xu, Xiangdong; Yamada, Akira; Yamamoto, Kazuya; Yamanoue, Hiroki; Yamashita, Takeshi; Bryan Yan, Ping Yen; Yang, Yanmin; Yang, Tianlun; Yao, Jing; Yarlagadda, Chakri; Yeh, Kuo Ho; Yotov, Yoto; Yvorra, Serge; Zahn, Ralf; Zamorano, José; Zanini, Roberto; Zarich, Stuart; Zebrack, James; Zenin, Sergei; Zeuthen, Elisabeth Louise; Zhang, Xingwei; Zhang, Quansan; Zhang, Dadong; Zhang, Donghui; Zhang, Huanyi; Zhao, Shuiping; Zhao, Xinwen; Zheng, Yang; Zheng, Qiangsun; Zhou, Jing; Zhou, Jian; Zimmermann, Sergio Luiz; Zimmermann, Rainer; Zukerman, L. Steven; Zwaan van der, C.
2017
Abstract
Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701)
Citazione
The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2 / Huisman, Menno V; Rothman, Kenneth J.; Paquette, Miney; Teutsch, Christine; Diener, Hans Christoph; Dubner, Sergio J.; Halperin, Jonathan L.; Ma, Chang Sheng; Zint, Kristina; Elsaesser, Amelie; Bartels, Dorothee B.; Lip, Gregory Y. H.; Abban, Dzifa; Abdul, Nasser; Abelson, Mark; Ackermann, Alan; Adams, Fran; Adams, Luthando; Adragão, Pedro; Ageno, Walter; Aggarwal, Rajesh; Agosti, Sergio; Marin, Javier Aguila; Aguilar, Francisco; Aguilar Linares, Julio Alberto; Aguinaga, Luis; Ahmad, Zia; Ainsworth, Paul; Al Ghalayini, Kamal; Al Ismail, Saad; Alasfar, Abdelfatah; Alawwa, Abdul; Al Dallow, Raed; Alderson, Lisa; Alexopoulos, Dimitrios; Ali, Abdullah; Ali, Malik; Aliyar, Pareed; Al Joundi, Tammam; Al Mahameed, Soufian; Almassi, Hossein; Almuti, Khalid; Al Obaidi, Mohamed; Alshehri, Mohamed; Altmann, Ute; Alves, Alvaro Rabelo; Al Zoebi, Ayham; Amara, Walid; Amelot, Mathieu; Amjadi, Nima; Ammirati, Fabrizio; Andrawis, Nabil; Angoulvant, Denis; Annoni, Giorgio; Ansalone, Gerardo; Antonescu, Sorin Alexandru; Ariani, Mehrdad; Arias, Juan Carlos; Armero, Sébastien; Arora, Rohit; Arora, Chander; Ashcraft, William; Aslam, M. 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