Chronic obstructive pulmonary disease (COPD) is a common chronic disease, being associated with both high rates of morbidity and mortality. Similarly, atrial fibrillation (AF) is associated with a higher risk of both cardiovascular (CV) events and overall mortality. The AF and COPD often coexist, but the impact of COPD on prognosis in European AF patients is unknown. Methods We evaluated COPD prevalence in patients enrolled in the EURObservational Research Programme Pilot Survey on Atrial Fibrillation Registry Pilot Phase. Clinical factors associated with COPD and adverse outcomes at 1-year follow-up were determined. Results In the overall cohort, a diagnosis of COPD was recorded in 339 (11.0%) of AF patients. The AF patients with COPD were more burdened with risk factors and comorbidities, including diabetes mellitus (P <.0001) and chronic heart failure (P <.0001). β-Blockers were less likely to be prescribed to patients with COPD (P =.0007). On follow-up, AF patients with COPD had a higher risk of both CV death and all-cause death (both P <.0001), as well as for the composite outcome of any thromboembolic event/bleeding /CV death (P =.0003). Cox regression analysis found that COPD was independently associated with an increase in all-cause death (hazard ratio, 1.55; 95% CI 1.05-2.28; P =.0269). Conclusions Chronic obstructive pulmonary disease is highly prevalent in European AF patients, and is associated with higher rates of CV death, all-cause death, and the composite outcome of any thromboembolic event/bleeding/CV death. The presence of COPD in AF patients was independently associated with all-cause death in AF patients.

Impact of chronic obstructive pulmonary disease on prognosis in atrial fibrillation: A report from the EURObservational Research Programme Pilot Survey on Atrial Fibrillation (EORP-AF) General Registry / Proietti, Marco; Laroche, Cécile; Drozd, Marcin; Vijgen, Johan; Cozma, Dragos C.; Drozdz, Jaroslaw; Maggioni, Aldo P.; Boriani, Giuseppe; Lip, Gregory Y. H.. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - 181:(2016), pp. 83-91. [10.1016/j.ahj.2016.08.011]

Impact of chronic obstructive pulmonary disease on prognosis in atrial fibrillation: A report from the EURObservational Research Programme Pilot Survey on Atrial Fibrillation (EORP-AF) General Registry

BORIANI, Giuseppe;
2016

Abstract

Chronic obstructive pulmonary disease (COPD) is a common chronic disease, being associated with both high rates of morbidity and mortality. Similarly, atrial fibrillation (AF) is associated with a higher risk of both cardiovascular (CV) events and overall mortality. The AF and COPD often coexist, but the impact of COPD on prognosis in European AF patients is unknown. Methods We evaluated COPD prevalence in patients enrolled in the EURObservational Research Programme Pilot Survey on Atrial Fibrillation Registry Pilot Phase. Clinical factors associated with COPD and adverse outcomes at 1-year follow-up were determined. Results In the overall cohort, a diagnosis of COPD was recorded in 339 (11.0%) of AF patients. The AF patients with COPD were more burdened with risk factors and comorbidities, including diabetes mellitus (P <.0001) and chronic heart failure (P <.0001). β-Blockers were less likely to be prescribed to patients with COPD (P =.0007). On follow-up, AF patients with COPD had a higher risk of both CV death and all-cause death (both P <.0001), as well as for the composite outcome of any thromboembolic event/bleeding /CV death (P =.0003). Cox regression analysis found that COPD was independently associated with an increase in all-cause death (hazard ratio, 1.55; 95% CI 1.05-2.28; P =.0269). Conclusions Chronic obstructive pulmonary disease is highly prevalent in European AF patients, and is associated with higher rates of CV death, all-cause death, and the composite outcome of any thromboembolic event/bleeding/CV death. The presence of COPD in AF patients was independently associated with all-cause death in AF patients.
2016
27-ago-2016
181
83
91
Impact of chronic obstructive pulmonary disease on prognosis in atrial fibrillation: A report from the EURObservational Research Programme Pilot Survey on Atrial Fibrillation (EORP-AF) General Registry / Proietti, Marco; Laroche, Cécile; Drozd, Marcin; Vijgen, Johan; Cozma, Dragos C.; Drozdz, Jaroslaw; Maggioni, Aldo P.; Boriani, Giuseppe; Lip, Gregory Y. H.. - In: AMERICAN HEART JOURNAL. - ISSN 0002-8703. - 181:(2016), pp. 83-91. [10.1016/j.ahj.2016.08.011]
Proietti, Marco; Laroche, Cécile; Drozd, Marcin; Vijgen, Johan; Cozma, Dragos C.; Drozdz, Jaroslaw; Maggioni, Aldo P.; Boriani, Giuseppe; Lip, Gregory Y. H.
File in questo prodotto:
File Dimensione Formato  
1-s2.0-S0002870316301740-main.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 341.57 kB
Formato Adobe PDF
341.57 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1139516
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 40
  • ???jsp.display-item.citation.isi??? 36
social impact