We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2)) calculated using the CKD-EPI formula was ≥80 in 35.1%, 50-79 in 47.2%, 30-49 in 13.9% and <30 in 3.7% of patients. In a logistic regression analysis, eGFR category was an independent predictor of stroke/TIA or death, with elevated odds ratios associated with severe to mild renal impairment, ie. eGFR < 30 ml/min/1.73 m(2) [OR 3.641, 95% CI 1.572-8.433, p < 0.0001], 30-49 ml/min/1.73 m(2) [OR 3.303, 95% CI 1.740-6.270, p = 0.0026] or 50-79 ml/min/1.73 m2 [OR 2.094, 95% CI 1.194-3.672, p = 0.0003]. The discriminant capability for the risk of death was tested among various eGFR calculation algorithms: the best was the Cockcroft-Gault equation adjusted for BSA, followed by Cockcroft-Gault equation, and CKD-EPI equation, while the worst was the MDRD equation. In conclusion in this prospective observational registry, renal function was a major determinant of adverse outcomes at 1 year, and even mild or moderate renal impairments were associated with an increased risk of stroke/TIA/death.

Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes / Boriani, Giuseppe; Laroche, C; Diemberger, I; Popescu, Mi; Rasmussen, Lh; Petrescu, L; Crijns, Hj; Tavazzi, L; Maggioni, Ap; Lip, G. Y.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:(2016), pp. 30271-30282. [10.1038/srep30271]

Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes

BORIANI, Giuseppe;
2016

Abstract

We assessed 1-year outcomes in patients with atrial fibrillation enrolled in the EurObservational Research Programme AF General Pilot Registry (EORP-AF), in relation to kidney function, as assessed by glomerular filtration rate (eGFR). In a cohort of 2398 patients (median age 69 years; 61% male), eGFR (ml/min/1.73 m(2)) calculated using the CKD-EPI formula was ≥80 in 35.1%, 50-79 in 47.2%, 30-49 in 13.9% and <30 in 3.7% of patients. In a logistic regression analysis, eGFR category was an independent predictor of stroke/TIA or death, with elevated odds ratios associated with severe to mild renal impairment, ie. eGFR < 30 ml/min/1.73 m(2) [OR 3.641, 95% CI 1.572-8.433, p < 0.0001], 30-49 ml/min/1.73 m(2) [OR 3.303, 95% CI 1.740-6.270, p = 0.0026] or 50-79 ml/min/1.73 m2 [OR 2.094, 95% CI 1.194-3.672, p = 0.0003]. The discriminant capability for the risk of death was tested among various eGFR calculation algorithms: the best was the Cockcroft-Gault equation adjusted for BSA, followed by Cockcroft-Gault equation, and CKD-EPI equation, while the worst was the MDRD equation. In conclusion in this prospective observational registry, renal function was a major determinant of adverse outcomes at 1 year, and even mild or moderate renal impairments were associated with an increased risk of stroke/TIA/death.
2016
6
30271
30282
Glomerular filtration rate in patients with atrial fibrillation and 1-year outcomes / Boriani, Giuseppe; Laroche, C; Diemberger, I; Popescu, Mi; Rasmussen, Lh; Petrescu, L; Crijns, Hj; Tavazzi, L; Maggioni, Ap; Lip, G. Y.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:(2016), pp. 30271-30282. [10.1038/srep30271]
Boriani, Giuseppe; Laroche, C; Diemberger, I; Popescu, Mi; Rasmussen, Lh; Petrescu, L; Crijns, Hj; Tavazzi, L; Maggioni, Ap; Lip, G. Y.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1139206
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