We tested the efficacy of 5-FU on secondary SCC in two melanoma patients who were being treated with the BRAF inhibitor dabrafenib (GSK2118436). We show that 5-FU provides a safe, noninvasive, inexpensive, and effective alternative to surgical intervention in clinical cases in which multiple surgeries are difficult or in cases in which lesions are incipient.
Topical 5-Fluorouracil Elicits Regressions of BRAF Inhibitor–Induced Cutaneous Squamous Cell Carcinoma / Viros, Amaya; Hayward, Robert; Martin, Matthew; Yashar, Sharona; Yu, Clarissa C.; Sanchez Laorden, Berta; Zambon, Alfonso; Niculescu Duvaz, Dan; Springer, Caroline; Lo, Roger S; Marais, Richard. - In: JOURNAL OF INVESTIGATIVE DERMATOLOGY. - ISSN 0022-202X. - 133:1(2013), pp. 274-276. [10.1038/jid.2012.268]
Topical 5-Fluorouracil Elicits Regressions of BRAF Inhibitor–Induced Cutaneous Squamous Cell Carcinoma
ZAMBON, Alfonso;
2013
Abstract
We tested the efficacy of 5-FU on secondary SCC in two melanoma patients who were being treated with the BRAF inhibitor dabrafenib (GSK2118436). We show that 5-FU provides a safe, noninvasive, inexpensive, and effective alternative to surgical intervention in clinical cases in which multiple surgeries are difficult or in cases in which lesions are incipient.
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