We report on the first well-tolerated and successful use of sofosbuvir-based therapy in a patient in whom chronic infection with hepatitis C had preceded the development of B-cell non-Hodgkin's lymphoma. The patient had previously failed numerous attempts to clear the hepatitis C virus with traditional antiviral schedules. We demonstrate that sofosbuvir-based therapy resulted in cure of hepatitis C in a patient who had relapsed during combination therapy with an NS5A inhibitor, an NS3 protease inhibitor and ribavirin, as well as treatment failures to multiple courses of interferon-based therapy. This report also suggests that eradication of hepatitis C virus may result in the short-term prevention of B-cell non-Hodgkin's lymphoma relapse. The findings from our case require further validation in future cohorts of patients.
Sofosbuvir-based therapy cures hepatitis C virus infection after prior treatment failures in a patient with concurrent lymphoma / Romagnoli, Dante; Marrazzo, Alessandra; Ballestri, Stefano; Lonardo, Amedeo; Bertolotti, Marco. - In: JOURNAL OF CLINICAL VIROLOGY. - ISSN 1386-6532. - 69(2015), pp. 74-77.
Data di pubblicazione: | 2015 |
Data di prima pubblicazione: | 30-mag-2015 |
Titolo: | Sofosbuvir-based therapy cures hepatitis C virus infection after prior treatment failures in a patient with concurrent lymphoma |
Autore/i: | Romagnoli, Dante; Marrazzo, Alessandra; Ballestri, Stefano; Lonardo, Amedeo; Bertolotti, Marco |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.jcv.2015.05.023 |
Rivista: | |
Volume: | 69 |
Pagina iniziale: | 74 |
Pagina finale: | 77 |
Codice identificativo ISI: | WOS:000358318400017 |
Codice identificativo Scopus: | 2-s2.0-84937865159 |
Codice identificativo Pubmed: | 26209383 |
Citazione: | Sofosbuvir-based therapy cures hepatitis C virus infection after prior treatment failures in a patient with concurrent lymphoma / Romagnoli, Dante; Marrazzo, Alessandra; Ballestri, Stefano; Lonardo, Amedeo; Bertolotti, Marco. - In: JOURNAL OF CLINICAL VIROLOGY. - ISSN 1386-6532. - 69(2015), pp. 74-77. |
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