Treatment with Liver X Receptor (LXR) agonists ameliorates disease manifestation in a mouse model of Wilson disease (WD) but only with a partial effect in inducing the predicted LXR target genes. These studies open new perspective for the oxysterols recptors LXR, involved not only in controlling lipid metabolism, inflammation, water transport and cell proliferation but also in regulating copper homeostasis.
Liver X receptors and copper metabolism: New frontiers for the oxysterol receptors / Gabbi, Chiara; Bertolotti, Marco. - In: HEPATOLOGY. - ISSN 0270-9139. - 64:4(2016), pp. 1371-1371. [10.1002/hep.28534]
Liver X receptors and copper metabolism: New frontiers for the oxysterol receptors
GABBI, Chiara;BERTOLOTTI, Marco
2016
Abstract
Treatment with Liver X Receptor (LXR) agonists ameliorates disease manifestation in a mouse model of Wilson disease (WD) but only with a partial effect in inducing the predicted LXR target genes. These studies open new perspective for the oxysterols recptors LXR, involved not only in controlling lipid metabolism, inflammation, water transport and cell proliferation but also in regulating copper homeostasis.
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