Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging data on the impact of patient stratification on treatment outcomes, European and American regulatory bodies support the principles of PM and its potential advantage over current treatment strategies. The aim of the current document was to propose a consensus on the position and gradual implementation of the principles of PM within existing adult treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS). At the time of diagnosis, prediction of success of the initiated treatment and patient participation in the decision of the treatment plan can be implemented. The second-level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long-term therapeutic strategy. Endotype-driven treatment is part of a personalized approach and should be positioned at the tertiary level of care, given the efforts needed for its implementation and the high cost of molecular diagnosis and biological treatment.
Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis - A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement / Aberer, W; Agache, I; Akdis, Ca; Akdis, M; Alobid, I; Ankri, J; Annesi Maesano, I; Ansotegui, Ij; Anto, Jm; Arnavielhe, S; Arshad, H; Asarnoj, A; Avolio, F; Bachert, C; Bachert, C; Baiardini, I; Barbagallo, M; Barbara, C; Baroody, F; Bateman, Ed; Bedbrook, A; Beghe', Bianca; Bel, Eh; Bennoor, Ks; Benson, M; Bergmann, Kc; Bewick, M; Bialoszewski, Az; Bieber, T; Bindslev Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, Al; Bonini, M; Bonini, S; Bosnic Anticevich, S; Bosse, I; Bouchard, J; Boulet, Lp; Bourret, R; Bousquet, J; Bousquet, Pj; Braido, F; Briggs, Ah; Brightling, Ce; Brozek, J; Bucca, C; Buhl, R; Bunu, C; Burte, E; Bush, A; Caballero Fonseca, F; Caimmi, Dp; Calderon, Ma; Camargos, Pa; Camuzat, T; Canonica, Gw; Cardona, V; Carlsen, Kh; Carr, W; Carreiro Martins, P; Carriazo, Am; Casale, T; Cepeda Sarabia, Am; Cervin, A; Cesari, M; Chatzi, L; Chavannes, Nh; Chiron, R; Chivato, T; Chkhartishvili, E; Chuchalin, Ag; Chung, Kf; Ciprandi, G; Cohen, N; Conzález Diaz, S; Cox, L; Crooks, G; Cruz, Aa; Custovic, A; Dahl, R; Dahlen, Se; Darsow, U; De Carlo, G; De Manuel Keenoy, E; de Sousa, Jc; De Vries, G; Dedeu, T; Deleanu, D; Demoly, P; Denburg, Ja; Devillier, P; Didier, A; Dinh Xuan, At; Dokic, D; Douagui, H; Douglas, R; Dray, G; Du Toit, G; Dubakiene, R; Durham, Sr; Dykewicz, Ms; Eklund, P; El Gamal, Y; Ellers, E; Emuzyte, R; Farrell, J; Fink Wagner, A; Fiocchi, A; Fletcher, M; Fokkens, Wj; Fonseca, J; Forastiere, F; Gaga, M; Gamkrelidze, A; Gemicioğlu, B; Georgalas, C; Gereda, Je; Gevaert, P; Goossens, H; Grisle, I; Guldemond, Na; Gutter, Z; Guzmán, Ma; Haahtela, T; Harvey, R; Heinrich, J; Hellings, Pw; Hellings, Pw; Hellquist Dahl, B; Hopkins, C; Horak, F; Hourihane, Jo; Humbert, M; Hyland, M; Iaccarino, G; Illario, M; Jares, Ej; Jeandel, C; Johnston, Sl; Jonquet, O; Joos, G; Joos, G; Jung, Ks; Just, J; Jutel, M; Kaidashev, I; Kalayci, O; Kalogjera, L; Kalyoncu, Af; Kardas, P; Keil, T; Keith, Pk; Kerkhof, M; Kern, B; Kerstjens, Ha; Khaitov, M; Khaltaev, N; Klimek, L; Kogevinas, M; Kolek, V; Koppelman, Gh; Kowalski, M; Kowalski, Ml; Kuitunen, M; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Larenas Linnemann, D; Lau, S; Laune, D; Le, Lt; Li, J; Lieberman, P; Lipworth, B; Lodrup Carlsen, Kc; Louis, R; Lund, Vj; Lupinek, C; MacNee, W; Magar, Y; Magnan, A; Mahboub, B; Maier, D; Majer, I; Malva, J; Manning, P; Marshall, Gd; Masjedi, Mr; Mathieu Dupas, E; Maurer, M; Mavale Manuel, S; Melén, E; Melo Gomes, E; Meltzer, Eo; Mercier, J; Merk, H; Miculinic, N; Mihaltan, F; Milenkovic, B; Millot Keurinck, J; Mohammad, Y; Momas, I; Morais Almeida, M; Mösges, R; Mullol, J; Mullol, J; Muraro, A; Murray, R; Naclerio, R; Nadif, R; Namazova Baranova, L; Neffen, H; Nekam, K; Nieto, A; Niggemann, B; Nogueira Silva, L; Nogues, M; Nyembue, Td; O'Hehir, Re; Ohta, K; Okamoto, Y; Okubo, K; Olive Elias, M; Ouedraogo, S; Paggiaro, P; Pali Schöll, I; Palkonen, S; Panzner, P; Papadopoulos, Ng; Papi, A; Park, Hs; Passalacqua, G; Pawankar, R; Pedersen, S; Pereira, Am; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Pohl, W; Popov, Ta; Portejoie, F; Postma, D; Potter, P; Poulsen, Lk; Price, D; Price, D; Rabe, Kf; Raciborski, F; Riechelmann, H; Robalo Cordeiro, C; Roberts, G; Rodenas, F; Rodriguez Mañas, L; Rolland, C; Roman Rodriguez, M; Romano, A; Rosado Pinto, J; Rosario, N; Rottem, M; Ryan, D; Samolinski, B; Sanchez Borges, M; Sastre Dominguez, J; Scadding, Gk; Schlosser, R; Schmid Grendelmeier, P; Schunemann, Hj; Scichilone, N; Senior, B; Serrano, E; Sheikh, A; Shields, M; Simons, F; Siroux, V; Sisul, Jc; Skrindo, I; Smit, Ha; Solé, D; Sooronbaev, T; Spranger, O; Stellato, C; Stelmach, R; Sterk, Pj; Strandberg, T; Sunyer, J; Thijs, C; Thomas, M; Todo Bom, A; Tomazic, Pv; Toskala, E; Triggiani, M; Valenta, R; Valero, A; Valiulis, A; Valovirta, E; van Eerd, M; van Ganse, E; van Hague, M; van Wick, Rg; Vandenplas, O; Varona, Ll; Vazankari, T; Vellas, B; Ventura, Mt; Vezzani, G; Viegi, G; Voegels, R; Vontetsianos, T; Wagenmann, M; Wahn, U; Walker, S; Wang, Dy; Wang, Y; Werfel, T; Whalley, B; Wickman, M; Williams, Dm; Williams, S; Wilson, N; Wormald, Pj; Wright, J; Yawn, Bp; Yiallouros, Pk; Yorgancioglu, A; Young, I; Yusuf, Om; Zaidi, A; Zar, Hj; Zernotti, Me; Zhang, L; Zhong, N; Zidarn, M; Zuberbier, TBeghé; Bianca,. - In: ALLERGY. - ISSN 1398-9995. - 72:9(2017), pp. 1297-1305. [10.1111/all.13162]
Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis - A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement.
Aberer W; Agache I; Akdis CA; Akdis M; Alobid I; Ankri J; Annesi Maesano I; Ansotegui IJ; Anto JM; Arnavielhe S; Arshad H; Asarnoj A; Avolio F; Bachert C; Bachert C; Baiardini I; Barbagallo M; Barbara C; Baroody F; Bateman ED; Bedbrook A; BEGHE', Bianca ;Bel EH; Bennoor KS; Benson M; Bergmann KC; Bewick M; Bialoszewski AZ; Bieber T; Bindslev Jensen C; Bjermer L; Blain H; Blasi F; Boner AL; Bonini M; Bonini S; Bosnic Anticevich S; Bosse I; Bouchard J; Boulet LP; Bourret R; Bousquet J; Bousquet PJ; Braido F; Briggs AH; Brightling CE; Brozek J; Bucca C; Buhl R; Bunu C; Burte E; Bush A; Caballero Fonseca F; Caimmi DP; Calderon MA; Camargos PA; Camuzat T; Canonica GW; Cardona V; Carlsen KH; Carr W; Carreiro Martins P; Carriazo AM; Casale T; Cepeda Sarabia AM; Cervin A; Cesari M; Chatzi L; Chavannes NH; Chiron R; Chivato T; Chkhartishvili E; Chuchalin AG; Chung KF; Ciprandi G; Cohen N; Conzález Diaz S; Cox L; Crooks G; Cruz AA; Custovic A; Dahl R; Dahlen SE; Darsow U; De Carlo G; De Manuel Keenoy E; de Sousa JC; De Vries G; Dedeu T; Deleanu D; Demoly P; Denburg JA; Devillier P; Didier A; Dinh Xuan AT; Dokic D; Douagui H; Douglas R; Dray G; Du Toit G; Dubakiene R; Durham SR; Dykewicz MS; Eklund P; El Gamal Y; Ellers E; Emuzyte R; Farrell J; Fink Wagner A; Fiocchi A; Fletcher M; Fokkens WJ; Fonseca J; Forastiere F; Gaga M; Gamkrelidze A; Gemicioğlu B; Georgalas C; Gereda JE; Gevaert P; Goossens H; Grisle I; Guldemond NA; Gutter Z; Guzmán MA; Haahtela T; Harvey R; Heinrich J; Hellings PW; Hellings PW; Hellquist Dahl B; Hopkins C; Horak F; Hourihane JO; Humbert M; Hyland M; Iaccarino G; Illario M; Jares EJ; Jeandel C; Johnston SL; Jonquet O; Joos G; Joos G; Jung KS; Just J; Jutel M; Kaidashev I; Kalayci O; Kalogjera L; Kalyoncu AF; Kardas P; Keil T; Keith PK; Kerkhof M; Kern B; Kerstjens HA; Khaitov M; Khaltaev N; Klimek L; Kogevinas M; Kolek V; Koppelman GH; Kowalski M; Kowalski ML; Kuitunen M; Kull I; Kuna P; Kvedariene V; Lambrecht B; Larenas Linnemann D; Lau S; Laune D; Le LT; Li J; Lieberman P; Lipworth B; Lodrup Carlsen KC; Louis R; Lund VJ; Lupinek C; MacNee W; Magar Y; Magnan A; Mahboub B; Maier D; Majer I; Malva J; Manning P; Marshall GD; Masjedi MR; Mathieu Dupas E; Maurer M; Mavale Manuel S; Melén E; Melo Gomes E; Meltzer EO; Mercier J; Merk H; Miculinic N; Mihaltan F; Milenkovic B; Millot Keurinck J; Mohammad Y; Momas I; Morais Almeida M; Mösges R; Mullol J; Mullol J; Muraro A; Murray R; Naclerio R; Nadif R; Namazova Baranova L; Neffen H; Nekam K; Nieto A; Niggemann B; Nogueira Silva L; Nogues M; Nyembue TD; O'Hehir RE; Ohta K; Okamoto Y; Okubo K; Olive Elias M; Ouedraogo S; Paggiaro P; Pali Schöll I; Palkonen S; Panzner P; Papadopoulos NG; Papi A; Park HS; Passalacqua G; Pawankar R; Pedersen S; Pereira AM; Pfaar O; Picard R; Pigearias B; Pin I; Plavec D; Pohl W; Popov TA; Portejoie F; Postma D; Potter P; Poulsen LK; Price D; Price D; Rabe KF; Raciborski F; Riechelmann H; Robalo Cordeiro C; Roberts G; Rodenas F; Rodriguez Mañas L; Rolland C; Roman Rodriguez M; Romano A; Rosado Pinto J; Rosario N; Rottem M; Ryan D; Samolinski B; Sanchez Borges M; Sastre Dominguez J; Scadding GK; Schlosser R; Schmid Grendelmeier P; Schunemann HJ; Scichilone N; Senior B; Serrano E; Sheikh A; Shields M; Simons F; Siroux V; Sisul JC; Skrindo I; Smit HA; Solé D; Sooronbaev T; Spranger O; Stellato C; Stelmach R; Sterk PJ; Strandberg T; Sunyer J; Thijs C; Thomas M; Todo Bom A; Tomazic PV; Toskala E; Triggiani M; Valenta R; Valero A; Valiulis A; Valovirta E; van Eerd M; van Ganse E; van Hague M; van Wick RG; Vandenplas O; Varona LL; Vazankari T; Vellas B; Ventura MT; Vezzani G; Viegi G; Voegels R; Vontetsianos T; Wagenmann M; Wahn U; Walker S; Wang DY; Wang Y; Werfel T; Whalley B; Wickman M; Williams DM; Williams S; Wilson N; Wormald PJ; Wright J; Yawn BP; Yiallouros PK; Yorgancioglu A; Young I; Yusuf OM; Zaidi A; Zar HJ; Zernotti ME; Zhang L; Zhong N; Zidarn M; Zuberbier TBeghé; Bianca
2017
Abstract
Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging data on the impact of patient stratification on treatment outcomes, European and American regulatory bodies support the principles of PM and its potential advantage over current treatment strategies. The aim of the current document was to propose a consensus on the position and gradual implementation of the principles of PM within existing adult treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS). At the time of diagnosis, prediction of success of the initiated treatment and patient participation in the decision of the treatment plan can be implemented. The second-level approach ideally involves strategies to prevent progression of disease, in addition to prediction of success of therapy, and patient participation in the long-term therapeutic strategy. Endotype-driven treatment is part of a personalized approach and should be positioned at the tertiary level of care, given the efforts needed for its implementation and the high cost of molecular diagnosis and biological treatment.
Citazione
Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis - A EUFOREA-ARIA-EPOS-AIRWAYS ICP statement / Aberer, W; Agache, I; Akdis, Ca; Akdis, M; Alobid, I; Ankri, J; Annesi Maesano, I; Ansotegui, Ij; Anto, Jm; Arnavielhe, S; Arshad, H; Asarnoj, A; Avolio, F; Bachert, C; Bachert, C; Baiardini, I; Barbagallo, M; Barbara, C; Baroody, F; Bateman, Ed; Bedbrook, A; Beghe', Bianca; Bel, Eh; Bennoor, Ks; Benson, M; Bergmann, Kc; Bewick, M; Bialoszewski, Az; Bieber, T; Bindslev Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, Al; Bonini, M; Bonini, S; Bosnic Anticevich, S; Bosse, I; Bouchard, J; Boulet, Lp; Bourret, R; Bousquet, J; Bousquet, Pj; Braido, F; Briggs, Ah; Brightling, Ce; Brozek, J; Bucca, C; Buhl, R; Bunu, C; Burte, E; Bush, A; Caballero Fonseca, F; Caimmi, Dp; Calderon, Ma; Camargos, Pa; Camuzat, T; Canonica, Gw; Cardona, V; Carlsen, Kh; Carr, W; Carreiro Martins, P; Carriazo, Am; Casale, T; Cepeda Sarabia, Am; Cervin, A; Cesari, M; Chatzi, L; Chavannes, Nh; Chiron, R; Chivato, T; Chkhartishvili, E; Chuchalin, Ag; Chung, Kf; Ciprandi, G; Cohen, N; Conzález Diaz, S; Cox, L; Crooks, G; Cruz, Aa; Custovic, A; Dahl, R; Dahlen, Se; Darsow, U; De Carlo, G; De Manuel Keenoy, E; de Sousa, Jc; De Vries, G; Dedeu, T; Deleanu, D; Demoly, P; Denburg, Ja; Devillier, P; Didier, A; Dinh Xuan, At; Dokic, D; Douagui, H; Douglas, R; Dray, G; Du Toit, G; Dubakiene, R; Durham, Sr; Dykewicz, Ms; Eklund, P; El Gamal, Y; Ellers, E; Emuzyte, R; Farrell, J; Fink Wagner, A; Fiocchi, A; Fletcher, M; Fokkens, Wj; Fonseca, J; Forastiere, F; Gaga, M; Gamkrelidze, A; Gemicioğlu, B; Georgalas, C; Gereda, Je; Gevaert, P; Goossens, H; Grisle, I; Guldemond, Na; Gutter, Z; Guzmán, Ma; Haahtela, T; Harvey, R; Heinrich, J; Hellings, Pw; Hellings, Pw; Hellquist Dahl, B; Hopkins, C; Horak, F; Hourihane, Jo; Humbert, M; Hyland, M; Iaccarino, G; Illario, M; Jares, Ej; Jeandel, C; Johnston, Sl; Jonquet, O; Joos, G; Joos, G; Jung, Ks; Just, J; Jutel, M; Kaidashev, I; Kalayci, O; Kalogjera, L; Kalyoncu, Af; Kardas, P; Keil, T; Keith, Pk; Kerkhof, M; Kern, B; Kerstjens, Ha; Khaitov, M; Khaltaev, N; Klimek, L; Kogevinas, M; Kolek, V; Koppelman, Gh; Kowalski, M; Kowalski, Ml; Kuitunen, M; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Larenas Linnemann, D; Lau, S; Laune, D; Le, Lt; Li, J; Lieberman, P; Lipworth, B; Lodrup Carlsen, Kc; Louis, R; Lund, Vj; Lupinek, C; MacNee, W; Magar, Y; Magnan, A; Mahboub, B; Maier, D; Majer, I; Malva, J; Manning, P; Marshall, Gd; Masjedi, Mr; Mathieu Dupas, E; Maurer, M; Mavale Manuel, S; Melén, E; Melo Gomes, E; Meltzer, Eo; Mercier, J; Merk, H; Miculinic, N; Mihaltan, F; Milenkovic, B; Millot Keurinck, J; Mohammad, Y; Momas, I; Morais Almeida, M; Mösges, R; Mullol, J; Mullol, J; Muraro, A; Murray, R; Naclerio, R; Nadif, R; Namazova Baranova, L; Neffen, H; Nekam, K; Nieto, A; Niggemann, B; Nogueira Silva, L; Nogues, M; Nyembue, Td; O'Hehir, Re; Ohta, K; Okamoto, Y; Okubo, K; Olive Elias, M; Ouedraogo, S; Paggiaro, P; Pali Schöll, I; Palkonen, S; Panzner, P; Papadopoulos, Ng; Papi, A; Park, Hs; Passalacqua, G; Pawankar, R; Pedersen, S; Pereira, Am; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Pohl, W; Popov, Ta; Portejoie, F; Postma, D; Potter, P; Poulsen, Lk; Price, D; Price, D; Rabe, Kf; Raciborski, F; Riechelmann, H; Robalo Cordeiro, C; Roberts, G; Rodenas, F; Rodriguez Mañas, L; Rolland, C; Roman Rodriguez, M; Romano, A; Rosado Pinto, J; Rosario, N; Rottem, M; Ryan, D; Samolinski, B; Sanchez Borges, M; Sastre Dominguez, J; Scadding, Gk; Schlosser, R; Schmid Grendelmeier, P; Schunemann, Hj; Scichilone, N; Senior, B; Serrano, E; Sheikh, A; Shields, M; Simons, F; Siroux, V; Sisul, Jc; Skrindo, I; Smit, Ha; Solé, D; Sooronbaev, T; Spranger, O; Stellato, C; Stelmach, R; Sterk, Pj; Strandberg, T; Sunyer, J; Thijs, C; Thomas, M; Todo Bom, A; Tomazic, Pv; Toskala, E; Triggiani, M; Valenta, R; Valero, A; Valiulis, A; Valovirta, E; van Eerd, M; van Ganse, E; van Hague, M; van Wick, Rg; Vandenplas, O; Varona, Ll; Vazankari, T; Vellas, B; Ventura, Mt; Vezzani, G; Viegi, G; Voegels, R; Vontetsianos, T; Wagenmann, M; Wahn, U; Walker, S; Wang, Dy; Wang, Y; Werfel, T; Whalley, B; Wickman, M; Williams, Dm; Williams, S; Wilson, N; Wormald, Pj; Wright, J; Yawn, Bp; Yiallouros, Pk; Yorgancioglu, A; Young, I; Yusuf, Om; Zaidi, A; Zar, Hj; Zernotti, Me; Zhang, L; Zhong, N; Zidarn, M; Zuberbier, TBeghé; Bianca,. - In: ALLERGY. - ISSN 1398-9995. - 72:9(2017), pp. 1297-1305. [10.1111/all.13162]
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Aberer, W; Agache, I; Akdis, Ca; Akdis, M; Alobid, I; Ankri, J; Annesi Maesano, I; Ansotegui, Ij; Anto, Jm; Arnavielhe, S; Arshad, H; Asarnoj, A; Avolio, F; Bachert, C; Bachert, C; Baiardini, I; Barbagallo, M; Barbara, C; Baroody, F; Bateman, Ed; Bedbrook, A; Beghe', Bianca; Bel, Eh; Bennoor, Ks; Benson, M; Bergmann, Kc; Bewick, M; Bialoszewski, Az; Bieber, T; Bindslev Jensen, C; Bjermer, L; Blain, H; Blasi, F; Boner, Al; Bonini, M; Bonini, S; Bosnic Anticevich, S; Bosse, I; Bouchard, J; Boulet, Lp; Bourret, R; Bousquet, J; Bousquet, Pj; Braido, F; Briggs, Ah; Brightling, Ce; Brozek, J; Bucca, C; Buhl, R; Bunu, C; Burte, E; Bush, A; Caballero Fonseca, F; Caimmi, Dp; Calderon, Ma; Camargos, Pa; Camuzat, T; Canonica, Gw; Cardona, V; Carlsen, Kh; Carr, W; Carreiro Martins, P; Carriazo, Am; Casale, T; Cepeda Sarabia, Am; Cervin, A; Cesari, M; Chatzi, L; Chavannes, Nh; Chiron, R; Chivato, T; Chkhartishvili, E; Chuchalin, Ag; Chung, Kf; Ciprandi, G; Cohen, N; Conzález Diaz, S; Cox, L; Crooks, G; Cruz, Aa; Custovic, A; Dahl, R; Dahlen, Se; Darsow, U; De Carlo, G; De Manuel Keenoy, E; de Sousa, Jc; De Vries, G; Dedeu, T; Deleanu, D; Demoly, P; Denburg, Ja; Devillier, P; Didier, A; Dinh Xuan, At; Dokic, D; Douagui, H; Douglas, R; Dray, G; Du Toit, G; Dubakiene, R; Durham, Sr; Dykewicz, Ms; Eklund, P; El Gamal, Y; Ellers, E; Emuzyte, R; Farrell, J; Fink Wagner, A; Fiocchi, A; Fletcher, M; Fokkens, Wj; Fonseca, J; Forastiere, F; Gaga, M; Gamkrelidze, A; Gemicioğlu, B; Georgalas, C; Gereda, Je; Gevaert, P; Goossens, H; Grisle, I; Guldemond, Na; Gutter, Z; Guzmán, Ma; Haahtela, T; Harvey, R; Heinrich, J; Hellings, Pw; Hellings, Pw; Hellquist Dahl, B; Hopkins, C; Horak, F; Hourihane, Jo; Humbert, M; Hyland, M; Iaccarino, G; Illario, M; Jares, Ej; Jeandel, C; Johnston, Sl; Jonquet, O; Joos, G; Joos, G; Jung, Ks; Just, J; Jutel, M; Kaidashev, I; Kalayci, O; Kalogjera, L; Kalyoncu, Af; Kardas, P; Keil, T; Keith, Pk; Kerkhof, M; Kern, B; Kerstjens, Ha; Khaitov, M; Khaltaev, N; Klimek, L; Kogevinas, M; Kolek, V; Koppelman, Gh; Kowalski, M; Kowalski, Ml; Kuitunen, M; Kull, I; Kuna, P; Kvedariene, V; Lambrecht, B; Larenas Linnemann, D; Lau, S; Laune, D; Le, Lt; Li, J; Lieberman, P; Lipworth, B; Lodrup Carlsen, Kc; Louis, R; Lund, Vj; Lupinek, C; MacNee, W; Magar, Y; Magnan, A; Mahboub, B; Maier, D; Majer, I; Malva, J; Manning, P; Marshall, Gd; Masjedi, Mr; Mathieu Dupas, E; Maurer, M; Mavale Manuel, S; Melén, E; Melo Gomes, E; Meltzer, Eo; Mercier, J; Merk, H; Miculinic, N; Mihaltan, F; Milenkovic, B; Millot Keurinck, J; Mohammad, Y; Momas, I; Morais Almeida, M; Mösges, R; Mullol, J; Mullol, J; Muraro, A; Murray, R; Naclerio, R; Nadif, R; Namazova Baranova, L; Neffen, H; Nekam, K; Nieto, A; Niggemann, B; Nogueira Silva, L; Nogues, M; Nyembue, Td; O'Hehir, Re; Ohta, K; Okamoto, Y; Okubo, K; Olive Elias, M; Ouedraogo, S; Paggiaro, P; Pali Schöll, I; Palkonen, S; Panzner, P; Papadopoulos, Ng; Papi, A; Park, Hs; Passalacqua, G; Pawankar, R; Pedersen, S; Pereira, Am; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Pohl, W; Popov, Ta; Portejoie, F; Postma, D; Potter, P; Poulsen, Lk; Price, D; Price, D; Rabe, Kf; Raciborski, F; Riechelmann, H; Robalo Cordeiro, C; Roberts, G; Rodenas, F; Rodriguez Mañas, L; Rolland, C; Roman Rodriguez, M; Romano, A; Rosado Pinto, J; Rosario, N; Rottem, M; Ryan, D; Samolinski, B; Sanchez Borges, M; Sastre Dominguez, J; Scadding, Gk; Schlosser, R; Schmid Grendelmeier, P; Schunemann, Hj; Scichilone, N; Senior, B; Serrano, E; Sheikh, A; Shields, M; Simons, F; Siroux, V; Sisul, Jc; Skrindo, I; Smit, Ha; Solé, D; Sooronbaev, T; Spranger, O; Stellato, C; Stelmach, R; Sterk, Pj; Strandberg, T; Sunyer, J; Thijs, C; Thomas, M; Todo Bom, A; Tomazic, Pv; Toskala, E; Triggiani, M; Valenta, R; Valero, A; Valiulis, A; Valovirta, E; van Eerd, M; van Ganse, E; van Hague, M; van Wick, Rg; Vandenplas, O; Varona, Ll; Vazankari, T; Vellas, B; Ventura, Mt; Vezzani, G; Viegi, G; Voegels, R; Vontetsianos, T; Wagenmann, M; Wahn, U; Walker, S; Wang, Dy; Wang, Y; Werfel, T; Whalley, B; Wickman, M; Williams, Dm; Williams, S; Wilson, N; Wormald, Pj; Wright, J; Yawn, Bp; Yiallouros, Pk; Yorgancioglu, A; Young, I; Yusuf, Om; Zaidi, A; Zar, Hj; Zernotti, Me; Zhang, L; Zhong, N; Zidarn, M; Zuberbier, TBeghé; Bianca,
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