BACKGROUND Meningeal carcinomatosis is a rare complication in breast cancer patients. At present, there are no defined guidelines for its management. The efficacy of systemic treatment seems to depend on its ability to cross the blood-brain-barrier and its interaction with tumor vasculature. Metronomic chemotherapy is a known modality of drug administration able to inhibit tumor angiogenesis. CASE REPORT We present a case of symptomatic leptomeningeal carcinomatosis from breast cancer successfully treated with capecitabine. Based on the hypothesis that angiogenesis contributes to neoplastic meningitis, the patient was treated with a metronomic schedule that provided long-term clinical benefit with a very low toxicity profile. CONCLUSIONS To assess the real impact of metronomic chemotherapy in patients with meninges involvement, a phase II study will be starting soon in our institution. A review of the literature concerning the management of meningeal carcinomatosis is also presented.

Metronomic Capecitabine Effectively Blocks Leptomeningeal Carcinomatosis From Breast Cancer: A Case Report and Literature Review / Maur, Michela; Omarini, Claudia; Piacentini, Federico; Fontana, Annalisa; Pettorelli, Elisa; Cascinu, Stefano. - In: THE AMERICAN JOURNAL OF CASE REPORTS. - ISSN 1941-5923. - 18:(2017), pp. 208-2011. [10.12659/AJCR.901812]

Metronomic Capecitabine Effectively Blocks Leptomeningeal Carcinomatosis From Breast Cancer: A Case Report and Literature Review.

MAUR, Michela;OMARINI, Claudia;PIACENTINI, Federico;FONTANA, Annalisa;PETTORELLI, Elisa;CASCINU, Stefano
2017

Abstract

BACKGROUND Meningeal carcinomatosis is a rare complication in breast cancer patients. At present, there are no defined guidelines for its management. The efficacy of systemic treatment seems to depend on its ability to cross the blood-brain-barrier and its interaction with tumor vasculature. Metronomic chemotherapy is a known modality of drug administration able to inhibit tumor angiogenesis. CASE REPORT We present a case of symptomatic leptomeningeal carcinomatosis from breast cancer successfully treated with capecitabine. Based on the hypothesis that angiogenesis contributes to neoplastic meningitis, the patient was treated with a metronomic schedule that provided long-term clinical benefit with a very low toxicity profile. CONCLUSIONS To assess the real impact of metronomic chemotherapy in patients with meninges involvement, a phase II study will be starting soon in our institution. A review of the literature concerning the management of meningeal carcinomatosis is also presented.
2017
28-feb-2017
18
208
2011
Metronomic Capecitabine Effectively Blocks Leptomeningeal Carcinomatosis From Breast Cancer: A Case Report and Literature Review / Maur, Michela; Omarini, Claudia; Piacentini, Federico; Fontana, Annalisa; Pettorelli, Elisa; Cascinu, Stefano. - In: THE AMERICAN JOURNAL OF CASE REPORTS. - ISSN 1941-5923. - 18:(2017), pp. 208-2011. [10.12659/AJCR.901812]
Maur, Michela; Omarini, Claudia; Piacentini, Federico; Fontana, Annalisa; Pettorelli, Elisa; Cascinu, Stefano
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1137526
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