ABSTRACT From an evolutionary point of view, the thymus is a new organ observed for the first time in fish concomitantly with the appearance of adaptive clonotypical immunity. Hormone and neuropeptide expression was demonstrated in different species suggesting a conserved role of these molecules. An integrated evolution of immune and neuroendocrine responses appears to have been realized by means of the re-use of ancestral material, such as neuroendocrine cells and mediators, to create a thymic microenvironment for the maturation and differentiation of T cells.
Thymus: Conservation in evolution / Franchini, Antonella; Ottaviani, Enzo. - In: GENERAL AND COMPARATIVE ENDOCRINOLOGY. - ISSN 0016-6480. - 246:(2017), pp. 46-50. [10.1016/j.ygcen.2017.03.011]
Thymus: Conservation in evolution
FRANCHINI, Antonella;OTTAVIANI, Enzo
2017-01-01
Abstract
ABSTRACT From an evolutionary point of view, the thymus is a new organ observed for the first time in fish concomitantly with the appearance of adaptive clonotypical immunity. Hormone and neuropeptide expression was demonstrated in different species suggesting a conserved role of these molecules. An integrated evolution of immune and neuroendocrine responses appears to have been realized by means of the re-use of ancestral material, such as neuroendocrine cells and mediators, to create a thymic microenvironment for the maturation and differentiation of T cells.
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