Conducting polymer electrodes based on poly(3,4- ethylenedioxythiophene):polystyrene sulfonate were used to record electrophysiological signals from autonomous cardiac contractile cells present in embryoid bodies. Signal detection was carried-out by measuring the displacement current across the polymer/electrolyte double-layer capacitance, and compared with voltage detection. While for relatively low capacitance electrodes the voltage amplification provides higher signal quality, for high capacitive electrodes the displacement current method exhibits a higher signal-to-noise ratio. It is proposed that the displacement current method combined with high capacitive polymer-based electrodes is adequate to measure clusters of cells and whole organs. Our approach has a great potential in fundamental studies of drug discovery and safety pharmacology.
Bioelectrical signal detection using conducting polymer electrodes and the displacement current method / Inacio, Pedro; Mestre, Ana; de Medeiros, Maria; Asgarifar, Sanaz; Canudo, Joana; Elamine, Youssef; Santos, Joao; Morgado, Jorge; Braganca, Jose; Biscarini, Fabio; Gomes, Henrique. - In: IEEE SENSORS JOURNAL. - ISSN 1530-437X. - 17:13(2017), pp. 3961-3966.
Data di pubblicazione: | 2017 |
Titolo: | Bioelectrical signal detection using conducting polymer electrodes and the displacement current method |
Autore/i: | Inacio, Pedro; Mestre, Ana; de Medeiros, Maria; Asgarifar, Sanaz; Canudo, Joana; Elamine, Youssef; Santos, Joao; Morgado, Jorge; Braganca, Jose; Biscarini, Fabio; Gomes, Henrique |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1109/JSEN.2017.2703834 |
Rivista: | |
Volume: | 17 |
Fascicolo: | 13 |
Pagina iniziale: | 3961 |
Pagina finale: | 3966 |
Codice identificativo ISI: | WOS:000403465900002 |
Codice identificativo Scopus: | 2-s2.0-85020945526 |
Citazione: | Bioelectrical signal detection using conducting polymer electrodes and the displacement current method / Inacio, Pedro; Mestre, Ana; de Medeiros, Maria; Asgarifar, Sanaz; Canudo, Joana; Elamine, Youssef; Santos, Joao; Morgado, Jorge; Braganca, Jose; Biscarini, Fabio; Gomes, Henrique. - In: IEEE SENSORS JOURNAL. - ISSN 1530-437X. - 17:13(2017), pp. 3961-3966. |
Tipologia | Articolo su rivista |
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