Conducting polymer electrodes based on poly(3,4- ethylenedioxythiophene):polystyrene sulfonate were used to record electrophysiological signals from autonomous cardiac contractile cells present in embryoid bodies. Signal detection was carried-out by measuring the displacement current across the polymer/electrolyte double-layer capacitance, and compared with voltage detection. While for relatively low capacitance electrodes the voltage amplification provides higher signal quality, for high capacitive electrodes the displacement current method exhibits a higher signal-to-noise ratio. It is proposed that the displacement current method combined with high capacitive polymer-based electrodes is adequate to measure clusters of cells and whole organs. Our approach has a great potential in fundamental studies of drug discovery and safety pharmacology.

Bioelectrical signal detection using conducting polymer electrodes and the displacement current method / Inacio, Pedro; Mestre, Ana; de Medeiros, Maria; Asgarifar, Sanaz; Canudo, Joana; Elamine, Youssef; Santos, Joao; Morgado, Jorge; Braganca, Jose; Biscarini, Fabio; Gomes, Henrique. - In: IEEE SENSORS JOURNAL. - ISSN 1530-437X. - 17:13(2017), pp. 3961-3966.

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