A whole organic artificial synapse has been fabricated by patterning PEDOT:PSS electrodes on PDMS that are biased in frequency to yield a STP response. The timescale of the STP response is shown to be sensitive to the concentration of dopamine, DA, a neurotransmitter relevant for monitoring the development of Parkinson's disease and potential locoregional therapies. The sensitivity of the sensor towards DA has been validated comparing signal variation in the presence of DA and its principal interfering agent, ascorbic acid, AA. The whole organic synapse is biocompatible, soft and flexible, and is attractive for implantable devices aimed to real-time monitoring of DA concentration in bodily fluids. This may open applications in chronic neurodegenerative diseases such as Parkinson's disease.

Whole organic electronic synapses for dopamine detection / Giordani, Martina; DI LAURO, Michele; Berto, Marcello; Bortolotti, Carlo Augusto; Vuillaume, Dominique; Gomes, Henrique L.; Zoli, Michele; Biscarini, Fabio. - 9944:(2016), pp. 99440P-99440P. (Intervento presentato al convegno Organic Sensors and Bioelectronics IX tenutosi a usa nel 2016) [10.1117/12.2239532].

Whole organic electronic synapses for dopamine detection

GIORDANI, MARTINA;DI LAURO, MICHELE;berto, marcello;BORTOLOTTI, Carlo Augusto;ZOLI, Michele;BISCARINI, FABIO
2016

Abstract

A whole organic artificial synapse has been fabricated by patterning PEDOT:PSS electrodes on PDMS that are biased in frequency to yield a STP response. The timescale of the STP response is shown to be sensitive to the concentration of dopamine, DA, a neurotransmitter relevant for monitoring the development of Parkinson's disease and potential locoregional therapies. The sensitivity of the sensor towards DA has been validated comparing signal variation in the presence of DA and its principal interfering agent, ascorbic acid, AA. The whole organic synapse is biocompatible, soft and flexible, and is attractive for implantable devices aimed to real-time monitoring of DA concentration in bodily fluids. This may open applications in chronic neurodegenerative diseases such as Parkinson's disease.
2016
Organic Sensors and Bioelectronics IX
usa
2016
9944
99440P
99440P
Giordani, Martina; DI LAURO, Michele; Berto, Marcello; Bortolotti, Carlo Augusto; Vuillaume, Dominique; Gomes, Henrique L.; Zoli, Michele; Biscarini, ...espandi
Whole organic electronic synapses for dopamine detection / Giordani, Martina; DI LAURO, Michele; Berto, Marcello; Bortolotti, Carlo Augusto; Vuillaume, Dominique; Gomes, Henrique L.; Zoli, Michele; Biscarini, Fabio. - 9944:(2016), pp. 99440P-99440P. (Intervento presentato al convegno Organic Sensors and Bioelectronics IX tenutosi a usa nel 2016) [10.1117/12.2239532].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1136519
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