Dropwise cooling is a subject of interest for numerous industrial applications, which fosters fundamental research on the related mechanisms. The present work is focused on studying the cooling effect of 2 water droplets gently released onto a heated solid surface. The nominal initial temperature of the substrate was lower than 100 °C, thereby referring to evaporation regime. Heat-transfer phenomena were analyzed by an experimental and numerical approach at the solid/liquid interface and over non-wetted regions, thus evaluating mutual interaction between droplets. Infrared thermography was employed in a facility built to measure surface temperature from below through a fully non-intrusive approach. An infrared-transparent disk served as the substrate; its black-painted upper surface allowed heating and droplet deposition to occur on a blackbody. A numerical code was developed to model heat transfer within all bodies and at all interfaces by the finite-volume discretization method. Numerical results showed very good agreement with experimental temperature profiles and heat-flux distribution was predicted over the whole sampling region. Cooling effect was determined quantitatively together with the extent of the mutual-interaction region, where the influence of 2 sequentially-released droplets was proved higher and longer than that of a single-droplet configuration with the same amount of deposited water.