EnglishSpherical matrices (beads) of cross-linked carboxymethylcellulose were prepared by the in-liquid curing coating process using AlCl3 as curing agent (cross-linker). The loading process was carried out either by adding the drug to the polymer solutions before the extrusion process or by swelling the cross-linked beads in a drug solution. The energy dispersive X-ray (EDS) analysis showed a homogeneous distribution of both the drug concentration and cross-linking density in the network regardless to the loading procedure. When the loading process was carried out before the extrusion process, a residual amount of AICl3 remained in the beads. The effects of the residual amount of AlCl3 on the matrix swelling and drug release processes were analyzed.
| Data di pubblicazione: | 1993 |
| Titolo: | Effect of the loading method on the drug release from cross-linked carboxymethylcellulose beads |
| Autore/i: | Iannuccelli, Valentina; Forni, Flavio; Vandelli, Maria Angela; Bernabei, Mt |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | 10.1016/0168-3659(93)90066-E |
| Rivista: | |
| Volume: | 23 |
| Pagina iniziale: | 13 |
| Pagina finale: | 20 |
| Codice identificativo ISI: | WOS:A1993KG66200002 |
| Codice identificativo Scopus: | 2-s2.0-0027534240 |
| Citazione: | Effect of the loading method on the drug release from cross-linked carboxymethylcellulose beads / Iannuccelli, Valentina; Forni, Flavio; Vandelli, Maria Angela; Bernabei, Mt. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - STAMPA. - 23(1993), pp. 13-20. |
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http://hdl.handle.net/11380/11342
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