Spherical matrices (beads) of cross-linked carboxymethylcellulose were prepared by the in-liquid curing coating process using AlCl3 as curing agent (cross-linker). The loading process was carried out either by adding the drug to the polymer solutions before the extrusion process or by swelling the cross-linked beads in a drug solution. The energy dispersive X-ray (EDS) analysis showed a homogeneous distribution of both the drug concentration and cross-linking density in the network regardless to the loading procedure. When the loading process was carried out before the extrusion process, a residual amount of AICl3 remained in the beads. The effects of the residual amount of AlCl3 on the matrix swelling and drug release processes were analyzed.

Effect of the loading method on the drug release from cross-linked carboxymethylcellulose beads / Iannuccelli, Valentina; Forni, Flavio; Vandelli, Maria Angela; Bernabei, Mt. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - STAMPA. - 23(1993), pp. 13-20. [10.1016/0168-3659(93)90066-E]

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