CK2 and AKT display a high degree of cross-regulation of their respective functions, both directly, through physical interaction and phosphorylation, and indirectly, through an intense cross-talk of key downstream effectors, ultimately leading to sustained AKT activation.Being CK2 and AKT attractive targets for therapeutic intervention, here we would like to emphasize how AKT and CK2 might influence cell fate through their complex isoform-specific and contextual-dependent cross-talk, to the extent that such functional interplay should be considered when devising therapies that target one or both these key signaling kinases.

Cross-talk between the CK2 and AKT signaling pathways in cancer / Ruzzene, Maria; Bertacchini, Jessika; Toker, Alex; Marmiroli, Sandra. - In: ADVANCES IN BIOLOGICAL REGULATION. - ISSN 2212-4926. - 17:(2017), pp. 1-8. [10.1016/j.jbior.2017.03.002]

Cross-talk between the CK2 and AKT signaling pathways in cancer

BERTACCHINI, Jessika
Writing – Original Draft Preparation
;
TOKER, ALEX
Membro del Collaboration Group
;
MARMIROLI, Sandra
Supervision
2017

Abstract

CK2 and AKT display a high degree of cross-regulation of their respective functions, both directly, through physical interaction and phosphorylation, and indirectly, through an intense cross-talk of key downstream effectors, ultimately leading to sustained AKT activation.Being CK2 and AKT attractive targets for therapeutic intervention, here we would like to emphasize how AKT and CK2 might influence cell fate through their complex isoform-specific and contextual-dependent cross-talk, to the extent that such functional interplay should be considered when devising therapies that target one or both these key signaling kinases.
2017
28-mar-2017
17
1
8
Cross-talk between the CK2 and AKT signaling pathways in cancer / Ruzzene, Maria; Bertacchini, Jessika; Toker, Alex; Marmiroli, Sandra. - In: ADVANCES IN BIOLOGICAL REGULATION. - ISSN 2212-4926. - 17:(2017), pp. 1-8. [10.1016/j.jbior.2017.03.002]
Ruzzene, Maria; Bertacchini, Jessika; Toker, Alex; Marmiroli, Sandra
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1132179
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