Cell differentiation ultimately proceeds as a response to signals from the extracellu- lar microenvironment. If the cells are competent, that is, if they carry the correspond- ing receptors and signal transduction pathways, they can be triggered in the commit- ment state. In many cases the response includes complex gene expression programs whose progress and completion are relatively autonomous and whose outcome is determined by inherent regulatory factors of the cell type affected.' As a short introduction to the problems of differentiation and aging, we survey the main points that characterize the differentiation of hematopoietic cells. We can identify several main aspects.

Terminal differentiation / Ferrari, Sergio; Grande, Alexis; Manfredini, Rossella; Torelli, Umberto. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - STAMPA. - 663:(1992), pp. 180-186.

Terminal differentiation

FERRARI, Sergio;GRANDE, Alexis;MANFREDINI, Rossella;TORELLI, Umberto
1992

Abstract

Cell differentiation ultimately proceeds as a response to signals from the extracellu- lar microenvironment. If the cells are competent, that is, if they carry the correspond- ing receptors and signal transduction pathways, they can be triggered in the commit- ment state. In many cases the response includes complex gene expression programs whose progress and completion are relatively autonomous and whose outcome is determined by inherent regulatory factors of the cell type affected.' As a short introduction to the problems of differentiation and aging, we survey the main points that characterize the differentiation of hematopoietic cells. We can identify several main aspects.
1992
663
180
186
Terminal differentiation / Ferrari, Sergio; Grande, Alexis; Manfredini, Rossella; Torelli, Umberto. - In: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. - ISSN 0077-8923. - STAMPA. - 663:(1992), pp. 180-186.
Ferrari, Sergio; Grande, Alexis; Manfredini, Rossella; Torelli, Umberto
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/11305
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 7
  • ???jsp.display-item.citation.isi??? 7
social impact