Aging with HIV poses unique and complex challenges, including avoidance of neurocognitive disorder. Our objective here is to identify the prevalence and predictors of successful cognitive aging (SCA) in a sample of older adults with HIV. One hundred three HIV-infected individuals aged 50 and older were recruited from the Modena HIV Metabolic Clinic in Italy. Participants were treated with combination antiretroviral therapy for at least 1 year and had suppressed plasma HIV viral load. SCA was defined as the absence of neurocognitive impairment (as defined by deficits in tasks of episodic learning, information processing speed, executive function, and motor skills) depression, and functional impairment (instrumental activities of daily living). In cross-sectional analyses, odds of SCA were assessed in relation to HIV-related clinical data, HIV-Associated Non-AIDS (HANA) conditions, multimorbidity (≥2HANA conditions), and frailty. A frailty index was calculated as the number of deficits present out of 37 health variables. SCA was identified in 38.8% of participants. Despite no differences in average chronologic age between groups, SCA participants had significantly fewer HANA conditions, a lower frailty index, and were less likely to have hypertension. In addition, hypertension (odds ratio [OR] = 0.40, p = .04), multimorbidity (OR = 0.35, p = .05), and frailty (OR = 0.64, p = .04) were significantly associated with odds of SCA. Frailty is associated with the likelihood of SCA in people living with HIV. This defines an opportunity to apply knowledge from geriatric population research to people aging with HIV to better appreciate the complexity of their health status.

Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV / Wallace, Lindsay M. K; Ferrara, Maria; Brothers, Thomas D; Garlassi, Sara; Kirkland, Susan A; Theou, Olga; Zona, Stefano; Mussini, Cristina; Moore, David; Rockwood, Kenneth; Guaraldi, Giovanni. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 33:2(2017), pp. 157-163. [10.1089/AID.2016.0189]

Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV

FERRARA, Maria;GARLASSI, SARA;ZONA, Stefano;MUSSINI, Cristina;GUARALDI, Giovanni
2017

Abstract

Aging with HIV poses unique and complex challenges, including avoidance of neurocognitive disorder. Our objective here is to identify the prevalence and predictors of successful cognitive aging (SCA) in a sample of older adults with HIV. One hundred three HIV-infected individuals aged 50 and older were recruited from the Modena HIV Metabolic Clinic in Italy. Participants were treated with combination antiretroviral therapy for at least 1 year and had suppressed plasma HIV viral load. SCA was defined as the absence of neurocognitive impairment (as defined by deficits in tasks of episodic learning, information processing speed, executive function, and motor skills) depression, and functional impairment (instrumental activities of daily living). In cross-sectional analyses, odds of SCA were assessed in relation to HIV-related clinical data, HIV-Associated Non-AIDS (HANA) conditions, multimorbidity (≥2HANA conditions), and frailty. A frailty index was calculated as the number of deficits present out of 37 health variables. SCA was identified in 38.8% of participants. Despite no differences in average chronologic age between groups, SCA participants had significantly fewer HANA conditions, a lower frailty index, and were less likely to have hypertension. In addition, hypertension (odds ratio [OR] = 0.40, p = .04), multimorbidity (OR = 0.35, p = .05), and frailty (OR = 0.64, p = .04) were significantly associated with odds of SCA. Frailty is associated with the likelihood of SCA in people living with HIV. This defines an opportunity to apply knowledge from geriatric population research to people aging with HIV to better appreciate the complexity of their health status.
3-gen-2017
33
2
157
163
Lower Frailty Is Associated with Successful Cognitive Aging Among Older Adults with HIV / Wallace, Lindsay M. K; Ferrara, Maria; Brothers, Thomas D; Garlassi, Sara; Kirkland, Susan A; Theou, Olga; Zona, Stefano; Mussini, Cristina; Moore, David; Rockwood, Kenneth; Guaraldi, Giovanni. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 33:2(2017), pp. 157-163. [10.1089/AID.2016.0189]
Wallace, Lindsay M. K; Ferrara, Maria; Brothers, Thomas D; Garlassi, Sara; Kirkland, Susan A; Theou, Olga; Zona, Stefano; Mussini, Cristina; Moore, David; Rockwood, Kenneth; Guaraldi, Giovanni
File in questo prodotto:
File Dimensione Formato  
aid.2016.0189.pdf

accesso aperto

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 210.78 kB
Formato Adobe PDF
210.78 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1129597
Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 27
  • ???jsp.display-item.citation.isi??? 26
social impact