The coexistence of multiple and synchronous primary neoplasms in the same organ (including kidney) has only rarely been described in the literature. We herein present a case of collecting duct carcinoma (CDC) combined with papillary renal carcinoma (RCC) having a 57-month disease-free survival. CDC is a rather rare and aggressive neoplasm of the kidney. Sharing probably the same embryological origin, synchronous or metachronous association with in situ or papillary transitional cell carcinoma (TCC) may be found; association with RCC has been only once reported in the literature. The high incidence of c-erbB-2 oncogene amplification in CDC further characterizes this tumor as a separate entity from renal cell carcinoma, and shows some genetic characteristics in common with TCC. The histohgical diagnosis of Bellini CDC can be confirmed by the positive immuno-histochemical staining with a collecting duct marker and distal tubule marker and negative staining with a proximal tubule marker.

Synchronous collecting duct carcinoma and papillary renal cell carcinoma: A case report and review of the literature / Matei, Dv; Rocco, Bernardo Maria Cesare; Varela, R; Verweij, F; Scardino, E; Renne, G; De Cobelli, O.. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 25:1B(2005), pp. 579-586.

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