It is known that early sexual maturation contributes to an adverse metabolic programming. Our results support a direct and negative effect of GnRHa per se on BMI, glycaemic metabolism and lipid profile in children affected by CPP.Nevertheless, these consequences appear to be short-term and reversible.
The Metabolic Negative Effect of Gonadotropin-Releasing Hormone Agonist Therapy in Childhood: Is it Short-Term and Reversible? / Iughetti, Lorenzo; Bruzzi, Patrizia; Bigi, Elena; Valeri, Lara; Manzotti, Elena; Predieri, Barbara. - In: HORMONE RESEARCH IN PAEDIATRICS. - ISSN 1663-2818. - STAMPA. - 86:suppl- 1(2016), pp. 427-427. (Intervento presentato al convegno 55th Annual Meeting of the European Society for Paediatric Endocrinology tenutosi a Paris).
The Metabolic Negative Effect of Gonadotropin-Releasing Hormone Agonist Therapy in Childhood: Is it Short-Term and Reversible?
IUGHETTI, Lorenzo;BRUZZI, Patrizia;BIGI, ELENA;VALERI, LARA;Manzotti, Elena;PREDIERI, Barbara
2016
Abstract
It is known that early sexual maturation contributes to an adverse metabolic programming. Our results support a direct and negative effect of GnRHa per se on BMI, glycaemic metabolism and lipid profile in children affected by CPP.Nevertheless, these consequences appear to be short-term and reversible.
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