Arylsulfonylacetates can be viewed as synthetic equivalents of a variety of alpha-carboxylate anions. Phase-transfer catalysis (PTC) enabled their mild deprotonation and catalytic asymmetric addition to highly reactive imines generated in situ from alpha-amidosulfones (see scheme; Pg=protecting group). The synthetic utility of the products was demonstrated by their straightforward transformation into a range of beta-amino acid derivatives.
Catalytic Asymmetric Mannich Reactions of Sulfonylacetates / Cassani, Carlo; Bernardi, Luca; Fini, Francesco; Ricci, Alfredo. - In: ANGEWANDTE CHEMIE. INTERNATIONAL EDITION. - ISSN 1433-7851. - STAMPA. - 48:31(2009), pp. 5694-5697. [10.1002/anie.200900701]
Catalytic Asymmetric Mannich Reactions of Sulfonylacetates
FINI, Francesco;
2009
Abstract
Arylsulfonylacetates can be viewed as synthetic equivalents of a variety of alpha-carboxylate anions. Phase-transfer catalysis (PTC) enabled their mild deprotonation and catalytic asymmetric addition to highly reactive imines generated in situ from alpha-amidosulfones (see scheme; Pg=protecting group). The synthetic utility of the products was demonstrated by their straightforward transformation into a range of beta-amino acid derivatives.
| File | Dimensione | Formato | |
|---|---|---|---|
|
17 - Angew. Chem. Int. Ed. 2009 Cassani 5694-5697.pdf
Accesso riservato
Descrizione: Articolo Principale
Tipologia:
Versione pubblicata dall'editore
Dimensione
313.98 kB
Formato
Adobe PDF
|
313.98 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
