Objective: Recent research has suggested a dual impact of obsessive-compulsive dimension on functioning in schizophrenia with a gradual transition from an improving to a worsening effect depending on obsessive-compulsive symptoms (OCS) severity (from mild to moderate-severe). Aim of the present study was to investigate whether this varying effect of OCS on functioning might be mediated or moderated by schizophrenia symptom dimensions or occur independently. Method: Seventy-five patients affected by schizophrenia were administered the Structured Clinical Interview for DSM-IV Disorders, the Positive and Negative Syndrome Scale, the Yale-Brown Obsessive-Compulsive Scale and the Social and Occupational Functioning Assessment.The sample was divided into two groups according to the severity of OCS (absent/mild and moderate/high OCS group). Results: In both groups, the effect of OCS on functioning was not mediated by their effect on positive, negative or disorganization symptoms. Conversely, a significant interaction between OCS and disorganization dimension was found: the dual effect of OCS on functioning occurred only among patients with low disorganization symptoms while it was no more apparent at high levels of disorganization. Conclusion: Data suggest that in patients with schizophrenia, functioning at least in part depends on the interaction between disorganization and OCS.
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|Data di pubblicazione:||2016|
|Titolo:||Obsessive-compulsive symptoms interact with disorganization in influencing social functioning in schizophrenia|
|Autori:||Tonna, Matteo; Ottoni, Rebecca; Paglia, Francesca; Ossola, Paolo; De Panfilis, Chiara; Marchesi, Carlo|
|Digital Object Identifier (DOI):||10.1016/j.schres.2016.01.002|
|Appare nelle tipologie:||Articolo su rivista|
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