Gray phenotype: enhanced fitness strategy for Candida dubliniensis

In this study Yue H. et al described for the first time the gray phenotype and tristable white-gray-opaque transitions in Candida dubliniensis. Here we discuss some intriguing aspects related to this virulence trait of Candida dubliniensis in comparison to Candida albicans and within the wider and complex phenotypic switch phenomenon so typical of the virulence program of these opportunistic pathogenic fungi. In particular, the relationship between the presence of gray phenotype and prevalence of Candida dubliniensis in the oral cavity of HIV-positive subjects is pointed out.