In this study we show that corticosteroid-treated Il17a-/- mice develop invasive candidiasis from oropharyngeal infection whereas WT mice do not. By using an established murine model of oral candidiasis we document the spatial and temporal progression of fungal infection. The histological analysis of tissues in Il17a-/- mice showed massive infiltration of the fungus in the stomach and alterations of the gastrointestinal tract segments. Both increased permeability and mucosal ulcerations of the intestinal barrier are seen to favour Candida albicans dissemination which was quantified both in kidney and liver where typical candidal abscesses were detected. Neutrophils from Il17a-/- were as capable of phagocytosing the fungus comparable to that of WT mice, however, they showed decreased candidacidal ability. Our data implies that IL-17A is crucial for preventing the passage from mucosal to disseminated candidiasis. As such, our model may be suitable to study the mechanisms favouring Candida albicans translocation to internal organs.

Involvement of IL-17A in preventing the development of deep-seated candidiasis from oropharyngeal infection / Paolo, Mosci; Elena, Gabrielli; Eugenio, Luciano; Stefano, Perito; Antonio, Cassone; Pericolini, Eva; Anna, Vecchiarelli. - In: MICROBES AND INFECTION. - ISSN 1286-4579. - 16:8(2014), pp. 678-689. [10.1016/j.micinf.2014.06.007]

Involvement of IL-17A in preventing the development of deep-seated candidiasis from oropharyngeal infection

PERICOLINI, Eva;
2014

Abstract

In this study we show that corticosteroid-treated Il17a-/- mice develop invasive candidiasis from oropharyngeal infection whereas WT mice do not. By using an established murine model of oral candidiasis we document the spatial and temporal progression of fungal infection. The histological analysis of tissues in Il17a-/- mice showed massive infiltration of the fungus in the stomach and alterations of the gastrointestinal tract segments. Both increased permeability and mucosal ulcerations of the intestinal barrier are seen to favour Candida albicans dissemination which was quantified both in kidney and liver where typical candidal abscesses were detected. Neutrophils from Il17a-/- were as capable of phagocytosing the fungus comparable to that of WT mice, however, they showed decreased candidacidal ability. Our data implies that IL-17A is crucial for preventing the passage from mucosal to disseminated candidiasis. As such, our model may be suitable to study the mechanisms favouring Candida albicans translocation to internal organs.
2014
16
8
678
689
Involvement of IL-17A in preventing the development of deep-seated candidiasis from oropharyngeal infection / Paolo, Mosci; Elena, Gabrielli; Eugenio, Luciano; Stefano, Perito; Antonio, Cassone; Pericolini, Eva; Anna, Vecchiarelli. - In: MICROBES AND INFECTION. - ISSN 1286-4579. - 16:8(2014), pp. 678-689. [10.1016/j.micinf.2014.06.007]
Paolo, Mosci; Elena, Gabrielli; Eugenio, Luciano; Stefano, Perito; Antonio, Cassone; Pericolini, Eva; Anna, Vecchiarelli
File in questo prodotto:
File Dimensione Formato  
Mosci P. et al, Microbes and Infection IL17ako 2014.pdf

Open access

Descrizione: Mosci P. et al, Microbes and Infections, 2014
Tipologia: Versione pubblicata dall'editore
Dimensione 3.05 MB
Formato Adobe PDF
3.05 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1120021
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 13
social impact