Background and aims: Berberine (BBR) is an isoquinoline derivative alkaloid isolated from Rhizoma Coptidis traditionally used as anti diarrheic and, more recently, as hypolipidemic and insulin sensitizer agent. Thus, BBR could represent a potential therapeutic option for patients with polycystic ovary syndrome (PCOS). The aim of this study was to evaluate the clinical, metabolic and hormonal effects of BBR in PCOS women. Methods: Fifty oligoamenorrheic PCOS obese women and 50 age and Body Mass Index (BMI) matched healthy controls were enrolled. PCOS women received BBR treatment (500mg, 2 times daily) for 6 months. Clinical and biochemical parameters were assessed before and after the treatment period. Results: Total testosterone (p<0.01), free androgen index (p<0.01), androstenedione (p<0.01), sex hormone binding globulin (p<0.01), progesterone (p<0.01), total cholesterol (p=0.01), low density lipoprotein cholesterol (p<0.01), triglycerides (p<0.01), area under the curve of insulin (p<0.01), menses frequency (p<0.01) and Waist Circumference (p=0.04) significantly (p<0.05) improved after BBR treatment. No correlation was found between variations of insulin sensitivity and hormonal changes. Conclusions: BBR improves clinical, metabolic and reproductive features in PCOS women. Its mechanism of actions need to be elucidated in further studies. © 2013 European Society for Clinical Nutrition and Metabolism.
|Data di pubblicazione:||2013|
|Titolo:||Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity|
|Autore/i:||Orio, Francesco; Muscogiuri, Giovanna; Palomba, Stefano; Savastano, Silvia; Volpe, Alessio; Orio, Marcello; Colarieti, Giorgio; LA SALA, Giovanni Battista; Colao, Annamaria; Marciano, Francesca; Ascione, Antonio; Putignano, Pietro|
|Digital Object Identifier (DOI):||10.1016/j.clnme.2013.07.002|
|Codice identificativo Scopus:||2-s2.0-84884906815|
|Tipologia||Articolo su rivista|
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