This study evaluated the impact of different phenotypes of polycystic ovary syndrome (PCOS) on early trophoblast invasion and placentation. Pregnant patients with different PCOS phenotypes and healthy pregnant women, matched for age and body mass index, were enrolled. Histological analysis of trophoblastic and decidual tissue and macroscopic and microscopic assessment of the placentas were performed. Implantation-site vessels with endovascular trophoblast differed significantly among PCOS phenotypes. Placental weight, thickness, density and fetal-placental weight ratio were significantly different in the full-blown and nonpolycystic ovary (PCO) phenotypes versus the ovulatory and non-hyperandrogenic phenotypes. The incidence of macroscopic placental lesions was only significantly different between controls and the full-blown and non-PCO phenotypes. The overall incidence of microscopic placental lesions was significantly different among PCOS phenotypes and was significantly higher in the full-blown and non-PCO phenotypes than in the ovulatory and non-hyperandrogenic phenotypes. The rates of chorionic villitis and intervillositis were significantly higher in full-blown and non-PCO phenotypes than in ovulatory and non-hyperandrogenic phenotypes. In conclusion, alterations in early trophoblast invasion and placentation observed in PCOS vary widely according to phenotype.

Early trophoblast invasion and placentation in women with different PCOS phenotypes / Palomba, Stefano; Falbo, Angela; Chiossi, Giuseppe; Tolino, Achille; Tucci, Luigi; LA SALA, Giovanni Battista; Zullo, Fulvio. - In: REPRODUCTIVE BIOMEDICINE ONLINE. - ISSN 1472-6483. - 29:3(2014), pp. 370-381. [10.1016/j.rbmo.2014.04.010]

Early trophoblast invasion and placentation in women with different PCOS phenotypes

Palomba, Stefano;CHIOSSI, Giuseppe;LA SALA, Giovanni Battista;
2014

Abstract

This study evaluated the impact of different phenotypes of polycystic ovary syndrome (PCOS) on early trophoblast invasion and placentation. Pregnant patients with different PCOS phenotypes and healthy pregnant women, matched for age and body mass index, were enrolled. Histological analysis of trophoblastic and decidual tissue and macroscopic and microscopic assessment of the placentas were performed. Implantation-site vessels with endovascular trophoblast differed significantly among PCOS phenotypes. Placental weight, thickness, density and fetal-placental weight ratio were significantly different in the full-blown and nonpolycystic ovary (PCO) phenotypes versus the ovulatory and non-hyperandrogenic phenotypes. The incidence of macroscopic placental lesions was only significantly different between controls and the full-blown and non-PCO phenotypes. The overall incidence of microscopic placental lesions was significantly different among PCOS phenotypes and was significantly higher in the full-blown and non-PCO phenotypes than in the ovulatory and non-hyperandrogenic phenotypes. The rates of chorionic villitis and intervillositis were significantly higher in full-blown and non-PCO phenotypes than in ovulatory and non-hyperandrogenic phenotypes. In conclusion, alterations in early trophoblast invasion and placentation observed in PCOS vary widely according to phenotype.
2014
29
3
370
381
Early trophoblast invasion and placentation in women with different PCOS phenotypes / Palomba, Stefano; Falbo, Angela; Chiossi, Giuseppe; Tolino, Achille; Tucci, Luigi; LA SALA, Giovanni Battista; Zullo, Fulvio. - In: REPRODUCTIVE BIOMEDICINE ONLINE. - ISSN 1472-6483. - 29:3(2014), pp. 370-381. [10.1016/j.rbmo.2014.04.010]
Palomba, Stefano; Falbo, Angela; Chiossi, Giuseppe; Tolino, Achille; Tucci, Luigi; LA SALA, Giovanni Battista; Zullo, Fulvio
File in questo prodotto:
File Dimensione Formato  
Palomba S 2014 Reprod Biomed Online.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 865.06 kB
Formato Adobe PDF
865.06 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1117210
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 51
  • ???jsp.display-item.citation.isi??? 42
social impact