Ferutinin is a diaucane sesquiterpene with a high estrogenic activity. Since ferutinin is able to enhance osteoblastic differentiation of human amniotic fluid stem cells (hAFSCs), the aim of this study was to evaluate the role of the estrogen receptors α (ERα) and G-protein coupled receptor 30 (GPR30) in ferutinin-mediated osteoblastic differentiation. Moreover, it was investigated if MEK/ERK and PI3K/Akt signaling pathways are involved in ferutinin-induced effects.

Estrogen receptor signaling in the ferutinin-induced osteoblastic differentiation of human amniotic fluid stem cells / Zavatti, Manuela; Guida, M; Maraldi, Tullia; Beretti, Francesca; Bertoni, Laura; LA SALA, Giovanni Battista; DE POL, Anto. - In: LIFE SCIENCES. - ISSN 0024-3205. - 164:(2016), pp. 15-22. [10.1016/j.lfs.2016.09.005]

Estrogen receptor signaling in the ferutinin-induced osteoblastic differentiation of human amniotic fluid stem cells

ZAVATTI, Manuela;MARALDI, Tullia;BERETTI, Francesca;BERTONI, Laura;LA SALA, Giovanni Battista;DE POL, Anto
2016

Abstract

Ferutinin is a diaucane sesquiterpene with a high estrogenic activity. Since ferutinin is able to enhance osteoblastic differentiation of human amniotic fluid stem cells (hAFSCs), the aim of this study was to evaluate the role of the estrogen receptors α (ERα) and G-protein coupled receptor 30 (GPR30) in ferutinin-mediated osteoblastic differentiation. Moreover, it was investigated if MEK/ERK and PI3K/Akt signaling pathways are involved in ferutinin-induced effects.
2016
11-set-2016
164
15
22
Estrogen receptor signaling in the ferutinin-induced osteoblastic differentiation of human amniotic fluid stem cells / Zavatti, Manuela; Guida, M; Maraldi, Tullia; Beretti, Francesca; Bertoni, Laura; LA SALA, Giovanni Battista; DE POL, Anto. - In: LIFE SCIENCES. - ISSN 0024-3205. - 164:(2016), pp. 15-22. [10.1016/j.lfs.2016.09.005]
Zavatti, Manuela; Guida, M; Maraldi, Tullia; Beretti, Francesca; Bertoni, Laura; LA SALA, Giovanni Battista; DE POL, Anto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1116452
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