Patients with acute promyelocytic leukaemia (APL) are usually considered at lower risk for developing an infectious complication (Girmenia et al, 2003), principally because current treatments are mainly based on the induction of myeloid differentiation rather than the highly myeloablative properties of standard chemotherapy used in patients with acute myeloid leukaemia (AML). This prospective study, conducted in 33 locations throughout Italy, evaluated the incidence of invasive fungal infection (IFI) and the clinical characteristics in patients with APL compared to patients affected by other AML subtypes treated with intensive chemotherapy.
Risk of invasive fungal infection in patients affected by acute promyelocytic leukaemia. A report by the SEIFEM-D registry / Pagano, Livio; Stamouli, Maria; Tumbarello, Mario; Verga, Luisa; Candoni, Anna; Cattaneo, Chiara; Nadali, Gianpaolo; Mitra, Maria Enza; Mancini, Valentina; Nosari, Annamaria; Garzia, Maria Grazia; Delia, Mario; Storti, Sergio; Spadea, Antonio; Caramatti, Cecilia; Perriello, Vincenzo; Sanna, Marco; Vacca, Adriana; De Paolis, Maria Rosaria; Potenza, Leonardo; Salutari, Prassede; Castagnola, Carlo; Fanci, Rosa; Chierichini, Anna; Melillo, Lorella; Picardi, Marco; Facchini, Luca; Martino, Bruno; Di Blasi, Roberta; Cesarini, Monica; Offidani, Massimo; Vianelli, Nicola; Caira, Morena; Lessi, Federica; Ferrari, Antonella; Venditti, Adriano; Pavone, Vincenzo; Lo Coco, Francesco; Aversa, Franco; Busca, Alessandro. - In: BRITISH JOURNAL OF HAEMATOLOGY. - ISSN 0007-1048. - STAMPA. - 170:3(2015), pp. 434-439. [10.1111/bjh.13308]
Risk of invasive fungal infection in patients affected by acute promyelocytic leukaemia. A report by the SEIFEM-D registry
Candoni, Anna;POTENZA, Leonardo;
2015
Abstract
Patients with acute promyelocytic leukaemia (APL) are usually considered at lower risk for developing an infectious complication (Girmenia et al, 2003), principally because current treatments are mainly based on the induction of myeloid differentiation rather than the highly myeloablative properties of standard chemotherapy used in patients with acute myeloid leukaemia (AML). This prospective study, conducted in 33 locations throughout Italy, evaluated the incidence of invasive fungal infection (IFI) and the clinical characteristics in patients with APL compared to patients affected by other AML subtypes treated with intensive chemotherapy.
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