New frontiers in nanomedicine are moving towards the research of new biomaterials. Apoferritin (APO), is a uniform regular self-assemblies nano-sized protein with excellent biocompatibility and a unique structure that affords it the ability to stabilize small active molecules in its inner core. Areas covered: APO can be loaded by applying a passive process (mainly used for ions and metals) or by a unique formulative approach based on disassemby/reassembly process. In this article, we aim to organize the experimental evidence provided by a number of studies on the loading, release and targeting. Attention is initially focused on the most investigated antineoplastic drug and contrast agents up to the most recent application in gene therapy. Expert opinion: Various preclinical studies have demonstrated that APO improved the potency and selectivity of some chemotherapeutics. However, in order to translate the use of APO into therapy, some issues must be solved, especially regarding the reproducibility of the loading protocol used, the optimization of nanocarrier characterization, detailed understanding of the final structure of loaded APO, and the real mechanism and timing of drug release.

Protein cage nanostructure as drug delivery system: magnifying glass on apoferritin / Belletti, Daniela; Pederzoli, Francesca; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni; Ruozi, Barbara. - In: EXPERT OPINION ON DRUG DELIVERY. - ISSN 1742-5247. - STAMPA. - (2017), pp. 825-840. [10.1080/17425247.2017.1243528]

Protein cage nanostructure as drug delivery system: magnifying glass on apoferritin

BELLETTI, Daniela;PEDERZOLI, FRANCESCA;FORNI, Flavio;VANDELLI, Maria Angela;TOSI, Giovanni;RUOZI, Barbara
2017

Abstract

New frontiers in nanomedicine are moving towards the research of new biomaterials. Apoferritin (APO), is a uniform regular self-assemblies nano-sized protein with excellent biocompatibility and a unique structure that affords it the ability to stabilize small active molecules in its inner core. Areas covered: APO can be loaded by applying a passive process (mainly used for ions and metals) or by a unique formulative approach based on disassemby/reassembly process. In this article, we aim to organize the experimental evidence provided by a number of studies on the loading, release and targeting. Attention is initially focused on the most investigated antineoplastic drug and contrast agents up to the most recent application in gene therapy. Expert opinion: Various preclinical studies have demonstrated that APO improved the potency and selectivity of some chemotherapeutics. However, in order to translate the use of APO into therapy, some issues must be solved, especially regarding the reproducibility of the loading protocol used, the optimization of nanocarrier characterization, detailed understanding of the final structure of loaded APO, and the real mechanism and timing of drug release.
21-ott-2016
825
840
Protein cage nanostructure as drug delivery system: magnifying glass on apoferritin / Belletti, Daniela; Pederzoli, Francesca; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni; Ruozi, Barbara. - In: EXPERT OPINION ON DRUG DELIVERY. - ISSN 1742-5247. - STAMPA. - (2017), pp. 825-840. [10.1080/17425247.2017.1243528]
Belletti, Daniela; Pederzoli, Francesca; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni; Ruozi, Barbara
File in questo prodotto:
File Dimensione Formato  
Protein cage nanostructure as drug delivery system magnifying glass on apoferritin.pdf

embargo fino al 30/09/2017

Tipologia: Post-print dell'autore (bozza post referaggio)
Dimensione 1.05 MB
Formato Adobe PDF
1.05 MB Adobe PDF Visualizza/Apri
belletti2017.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 8.43 MB
Formato Adobe PDF
8.43 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1114992
Citazioni
  • ???jsp.display-item.citation.pmc??? 12
  • Scopus 37
  • ???jsp.display-item.citation.isi??? 34
social impact